Classical imaging finding in callosal glioblastoma multiforme

Sharma, Rajaram; Tiwari, Tapendra; Goyal, Saurabh

doi:10.1136/bcr-2021-246679

Cited by 3 publications

(6 citation statements)

References 2 publications

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Section: Imagingmentioning

confidence: 99%

“…CT scan with contrast administration can be used as screening tool; however, post-contrast MRI is the investigation of choice for detail evaluation and Perspective Chapter: Glioblastoma of the Corpus Callosum DOI: http://dx.doi.org/10.5772/intechopen.110019 management including surgical planning [7,18,19]. Typically, corpus callosal GBM appears as a butterfly-shaped lesion with heterogeneous enhancement with areas of necrosis and haemorrhages with irregular postcontrast peripheral enhancement (Figure 1) [7,18]. Coronal as well as sagittal fluid-attenuated inversion recovery images shall help in delineating the lesion and their relationship with surrounding structures better, [18] and diffusion tensor imaging shall help for the identification of white fibre tracts [20].…”

Section: Imagingmentioning

confidence: 99%

“…A number of pathologies those involve corpus callosum can mimic butterfly glioblastomas including other lesser grade variants of gliomas involving corpus callosum, [22][23][24][25] lymphoma, metastasis, [26] toxoplasmosis, [27] demyelinating butterfly pseudo glioma, [28] and neuronal ceroid-lipofuscinosis (Kufs' disease) [29] because of its multiplanar capability, MRI with contrast enhancement and FLAIR sequence [7,18] can help to differentiate these lesions from each other; however, in doubtful cases the biopsy shall help to make the diagnosis.…”

Section: Differential Diagnosismentioning

confidence: 99%

“…Butterfly gliomas involving the corpus callosum characteristically appear as "butterfly" on imaging as the tumour has contiguous extension through the corpus callosum into both the cerebral hemispheres [1,3,4]. The incidence of butterfly glioma ranges from 3 to 14% of all high-grade gliomas [5,6], and the isolated corpus callosum GBM is a relatively unusual variant of butterfly glioblastoma and account for 3% of all GBM [7]. The butterfly GBM of the corpus callosum can be anterior involving genu or less commonly can be posterior involving splenium [1].…”

Section: Introductionmentioning

confidence: 99%

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Perspective Chapter: Glioblastoma of the Corpus Callosum

Kunwar¹,

Maurya²,

Deivasigamani³

et al. 2023

Glioblastoma - Current Evidence

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Glioma is the most common malignant tumour of the brain, in which glioblastoma (GBM) is the most aggressive form which infiltrates through the white fibre tracts. Corpus callosum (CC) is most invaded by GBM, it carries poor prognosis as mostly these tumours are not touched upon due to the belief of post operative cognitive decline, or there is incomplete resection leading to tumour recurrence. However current advancement in technology, operative techniques and better understanding of nature of CC-GBM, maximal safe resection is being carried out with better outcomes in comparison with the GBM without infiltration of CC.

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Section: Imagingmentioning

confidence: 99%

Section: Imagingmentioning

confidence: 99%

Section: Differential Diagnosismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Perspective Chapter: Glioblastoma of the Corpus Callosum

Kunwar¹,

Maurya²,

Deivasigamani³

et al. 2023

Glioblastoma - Current Evidence

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“…The CC (plural: corpora callosa) is the largest commissural ber that connects the cerebral cortex of the left and right hemispheres. It is the largest white matter C-shaped tract in the brain and measures about 10 cm in length (1). Neuroradiology is valuable in diagnosing the etiology, follow-up, and prognosis of people with epilepsy (1,2).…”

Section: Introductionmentioning

confidence: 99%

Measurements of the Corpus Callosum in epileptic patients Using Magnetic Resonance Imaging

Sharifi,

Rahimian,

Rafaati

et al. 2023

Preprint

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Background and Purpose: In recent years, magnetic resonance imaging (MRI) has been used to evaluate seizures in patients with epilepsy. The Corpus callosum (CC) serves as a crucial communication structure between the two brain hemispheres, making it valuable to study MRI changes in patients with epilepsy. This study aimed to measure the CC in patients with epilepsy and report any structural differences. Materials and Methods: We conducted a cross-sectional study involving 150 patients diagnosed with epilepsy. T2W MRI mid-sagittal cuts were taken to measure the length and width of the middle third of the CC. Results: The mean length of the CC was 6.89 ± 0.59 cm, while the mean width of the middle third of the CC was 3.23 ± 1.3 mm. Significant correlations were found between CC measurements and factors such as the number of drugs used, drug resistance, refractory epilepsy (RE), and the presence of MRI lesions. Conclusion: The results demonstrate that epilepsy affects the CC, and there is likely a correlation between CC width, the number of drugs used, drug resistance, and the presence of primary lesions in MRI. These findings can contribute to further studies on prognostic factors in epilepsy.

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Gliomas Infiltrating the Corpus Callosum: A Systematic Review of the Literature

Palmisciano

Ferini²,

Watanabe

et al. 2022

Cancers

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Background: Gliomas infiltrating the corpus callosum (G-I-CC) majorly impact patient quality-of-life, but maximally safe tumor resection is challenging. We systematically reviewed the literature on G-I-CC. Methods: PubMed, EMBASE, Scopus, Web of Science, and Cochrane were searched following the PRISMA guidelines to include studies of patients with G-I-CC. Clinicopathological features, treatments, and outcomes were analyzed. Results: We included 52 studies comprising 683 patients. Most patients experienced headache (33%), cognitive decline (18.7%), and seizures (17.7%). Tumors mostly infiltrated the corpus callosum genu (44.2%) with bilateral extension (85.4%) into frontal (68.3%) or parietal (8.9%) lobes. Most G-I-CC were glioblastomas (84.5%) with IDH-wildtype (84.9%) and unmethylated MGMT promoter (53.5%). Resection (76.7%) was preferred over biopsy (23.3%), mostly gross-total (33.8%) and subtotal (32.5%). The tumor-infiltrated corpus callosum was resected in 57.8% of cases. Radiation was delivered in 65.8% of patients and temozolomide in 68.3%. Median follow-up was 12 months (range, 0.1–116). In total, 142 patients (31.8%) experienced post-surgical complications, including transient supplementary motor area syndrome (5.1%) and persistent motor deficits (4.3%) or abulia (2.5%). Post-treatment symptom improvement was reported in 42.9% of patients. No differences in rates of complications (p = 0.231) and symptom improvement (p = 0.375) were found in cases with resected versus preserved corpus callosum. Recurrences occurred in 40.9% of cases, with median progression-free survival of 9 months (0.1–72). Median overall survival was 10.7 months (range, 0.1–116), significantly longer in low-grade tumors (p = 0.013) and after resection (p < 0.001), especially gross-total (p = 0.041) in patients with high-grade tumors. Conclusions: G-I-CC show clinicopathological patterns comparable to other more frequent gliomas. Maximally safe resection significantly improves survival with low rates of persistent complications.

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Classical imaging finding in callosal glioblastoma multiforme

Cited by 3 publications

References 2 publications

Perspective Chapter: Glioblastoma of the Corpus Callosum

Perspective Chapter: Glioblastoma of the Corpus Callosum

Measurements of the Corpus Callosum in epileptic patients Using Magnetic Resonance Imaging

Gliomas Infiltrating the Corpus Callosum: A Systematic Review of the Literature

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