Classification des tumeurs et malformations vasculaires. Apport de la classification ISSVA 2014/2018

Wassef, Michel; Borsik, M.; Cerceau, Pierre; Faucon, B.; Laurian, Claude; Clerc, N.; Lemarchand-Vénencie, F; Massoni, Claudine; Salvan, D.; Bisdorff-Bresson, A.

doi:10.1016/j.annpat.2020.11.004

Cited by 29 publications

(15 citation statements)

References 49 publications

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“…The subject of this retrospective analysis is patients diagnosed with VA from November 2014 to December 2020 who received systemic therapy with sirolimus in two pediatric centers. The VAs in our case series were categorized according to the classification of the International Society for the Study of Vascular Anomalies (ISSVA, 2018) ( 22 ).…”

Section: Methodsmentioning

confidence: 99%

Indications and Limitations of Sirolimus in the Treatment of Vascular Anomalies—Insights From a Retrospective Case Series

et al. 2022

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BackgroundDespite recent developments, the role of sirolimus in the heterogeneous spectrum of vascular anomalies is yet to be defined, in terms of indication, dosage, and therapy duration, recognizing both its potential and limitations.MethodsWe retrospectively analyzed 16 children with vascular anomalies treated with sirolimus in two pediatric centers between 2014 and 2020 [male: n = 7, the median age at diagnosis: 4.6 months (range, 0–281.4)]. In addition, repetitive volumetric analyses of the vascular anomalies were performed when possible (11 cases).ResultsTen patients were diagnosed with vascular malformations and 6 with vascular tumors. The mean therapy duration was 27.2 months (range, 3.5–65). The mean sirolimus level was 8.52 ng/ml (range, 5.38–12.88). All patients except one with central conducting lymphatic anomaly responded to sirolimus, with the most noticeable volume reduction in the first 4–6 months. Additional administration of vincristine was needed in five patients with kaposiform hemangioendothelioma and yielded a response, even in cases, refractory to sirolimus monotherapy. As a single agent, sirolimus led to impressive improvement in a patient with another vascular tumor—advanced epithelioid hemangioendothelioma. Complicated vascular malformations required long-term sirolimus therapy. Side effects of sirolimus included mucositis and laboratory abnormalities. No major infectious episodes were recorded. An infant with COVID-19, diagnosed while on sirolimus therapy, presented with a mild course.ConclusionIn the current series, we reported limitations of sirolimus as monotherapy, addressing the need to redefine its indications, and explore combination regimens and multimodal treatment strategies. Tools for objective evaluation of response trends over time could serve as a basis for the establishment of future therapeutic algorithms.

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Section: Methodsmentioning

confidence: 99%

Indications and Limitations of Sirolimus in the Treatment of Vascular Anomalies—Insights From a Retrospective Case Series

et al. 2022

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“…VMs are characterized by the irregular proliferation of endothelial cells of the blood vessels. They are considered as congenital inaccuracies of vascular morphogenesis that result in fragile endothelial cell proliferation inside the network of blood vessels [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

“…Vascular lesions were considered as hemangiomas before the1980s, and it was in 1982 that Mulliken and Glowacki proposed a classification for vascular anomalies based on pathological features [ 1 ]. Afterwards, the International Society for the Study of Vascular Anomalies (ISSVA) updated the old classification and splits vascular anomalies into two categories: vasoproliferative neoplasms (VN) and vascular malformations (VM) [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

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Angiographic Embolization with Histoacryl in Combination with Direct Injection of Bone Cement of an Intraosseous Venous Malformation of the Mandible: Report of a Case with 22-Year Follow-Up

Berbéri

Aoun

Aad

et al. 2022

Case Reports in Vascular Medicine

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Vascular malformations of the maxillofacial region are unusual, and they occur more rarely in bone than in soft tissue. Mandibular intraosseous vascular lesions represent 0.5-1.0% of all bone tumors, and they are classified as venous malformation, lymphatic malformation, arterial malformation, arteriovenous malformations, and arteriovenous fistulae. Venous malformation is the most common vascular malformation, accounting for 44-64% of all vascular malformations, and is considered a low-flow malformation. Endovascular therapy as selective angiographic embolization is considered as the first-choice treatment associated or not with emboli injections with a success rate of 70%, and this evades mutilating surgery and related sequelae. We report a case of mandibular venous malformation on a 45-year-old female complaining of unilateral swelling of the left body of the mandible with facial deformation. The computed tomography scan images and the T1-weighted MR images showed a lesion that expresses an expansible lesion in the spongy bone of the left of the mandible with a buccal cortical rupture. Signal voids were not identified, suggesting a low-flow vascular lesion. The T2-weighted images exposed hypersignals; accordingly, a vascular lesion was suspected. The treatment was done under locoregional analgesia; after selective angiography, direct histoacryl injection was completed, followed by bone cement injection. The patient was followed yearly since1998. Radiological images of 10-year follow-up MRI showed a stabilization of the lesion without any new extensions. The panoramic radiograph after 22 years showed a bone formation inside the body of the mandible. The long follow-up period and the absence of any complications are favorable for the adopted treatment plan.

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“…Por otra parte, según su ubicación, los hemangiomas pueden ser superficiales (cutáneos o subcutáneos) o profundos (intramusculares). [4][5][6][7][8][9] Los hemangiomas son comunes y pueden aparecer en tejidos superficiales o profundos, aunque rara vez involucran el pie. 4,5 Se caracterizan por presentar tres fases: una primera fase proliferativa, en la que la lesión crece aceleradamente; un período de estabilidad y, por último, una fase involutiva, en la que, independientemente del tratamiento, la lesión se atenúa de color y disminuye de tamaño.…”

Section: Discussionunclassified

Hemangioma capilar en el hallux: presentación de un caso

Rega¹

2022

Rev. Asoc. Arg. Ort. y Traumatol

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Introducción: Los hemangiomas son neoplasias benignas que se originan de células endoteliales; rara vez resultan malignos. El síntoma más común es el dolor, porque el hemangioma comprime un tronco nervioso cercano o un nervio directamente. Presentamos un caso de hemangioma en una región muy poco frecuente. Se trata de una mujer de 35 años que presentaba una tumoración friable, de coloración marrón, dolorosa, en la región distal del hallux, con aumento de tamaño en los últimos meses. Se realizó la exéresis completa de la tumoración. El diagnóstico anatomopatológico fue hemangioma capilar. No se observó recidiva luego de 36 meses de seguimiento. Conclusión: Frente a estas neoplasias, se recomienda la exéresis de la pieza y su posterior estudio.Nivel de Evidencia: IV

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Classification des tumeurs et malformations vasculaires. Apport de la classification ISSVA 2014/2018

Cited by 29 publications

References 49 publications

Indications and Limitations of Sirolimus in the Treatment of Vascular Anomalies—Insights From a Retrospective Case Series

Indications and Limitations of Sirolimus in the Treatment of Vascular Anomalies—Insights From a Retrospective Case Series

Angiographic Embolization with Histoacryl in Combination with Direct Injection of Bone Cement of an Intraosseous Venous Malformation of the Mandible: Report of a Case with 22-Year Follow-Up

Hemangioma capilar en el hallux: presentación de un caso

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