Classification, epidemiology and therapies for testicular germ cell tumours

Vasdev, Nikhil; Moon, Andrew M.; Thorpe, Andrew

doi:10.1387/ijdb.130031nv

Cited by 67 publications

(50 citation statements)

References 27 publications

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“…Incidence of 55 new cases per 100,000 males per year world-wide, and increase in number of diagnosed man with TC in US and other Western countries, makes it an important healthcare issue (1,2). The most affected subjects are young Caucasians (between age of 25 and 29 years) and some of the most rapid trends are observed in men of European descent, especially in Scandinavian countries (3).…”

Section: Abstract Background: the Ras Association Domain Family Protmentioning

confidence: 99%

Association Between RASSF1A Promoter Methylation and Testicular Germ Cell Tumor: A Meta-analysis and a Cohort Study

Markulin

Vojta

Samaržija

et al. 2017

CGP

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Section: Abstract Background: the Ras Association Domain Family Protmentioning

confidence: 99%

Association Between RASSF1A Promoter Methylation and Testicular Germ Cell Tumor: A Meta-analysis and a Cohort Study

Markulin

Vojta

Samaržija

et al. 2017

CGP

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“…A testicular yolk sac tumor is a type of NSGCT (1,3). Testicular yolk sac tumors are common in children exhibiting testicular cancer, however, they are rarely observed in adults (4).…”

Section: Discussionmentioning

confidence: 99%

“…According to testicular cancer guidelines (1,3,25), the current patient presented with a stage III tumor, therefore a PEB chemotherapy regimen was proposed for treatment. Follow-up assessments including general condition, serum markers and PET-CT should be regularly performed following chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

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Adult metastatic yolk sac tumor descending from an intra-abdominal testis: A case report and review of the literature

et al. 2015

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Abstract. Pure yolk sac tumors are extremely rare in adults; to the best of our knowledge, <20 cases have been reported. Multiple metastases originating from a pure yolk sac testicular tumor, descending from an intra-abdominal testis, are additionally extremely rare. In the present case, a man exhibiting a 30-year history of cryptorchidism and indirect inguinal hernia, was admitted to the Department of Urology (The Second Xiangya Hospital, Changsha, China) due to a mass that had descended from the abdominal cavity 7 months previously. Elevated levels of specific serum marker (α-fetoprotein, lactate dehydrogenase and human chorionic gonadotropin ) did not indicate potential testicular germ cell types prior to surgery and pathological examination. Pathological results and immunohistochemistry revealed a testicular pure yolk sac tumor subsequent to surgery. The present case report and literature review describes the typical characteristics of an adult testicular yolk sac tumor, as well as the diagnosis and management of the disease.

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“…However, TGCTs are the most frequently observed solid tumor among men aged between 15 and 35 years old (2). Additionally, it has been reported that the incidence of TGCTs has increased over the last 30-40 years (3).…”

Section: Introductionmentioning

confidence: 99%

AXIN1 protects against testicular germ cell tumors via the PI3K/AKT/mTOR signaling pathway

Yan

Jia

et al. 2017

Oncology Letters

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Abstract. Axis inhibition protein 1 (AXIN1) is characterized as a tumor suppressor in numerous types of cancer. However, the functional role of AXIN1 in the testicular germ cell tumors (TGCTs) remains unclear. The human embryonal carcinoma-derived cell line NTera2 was transfected with a recombinant AXIN1 expression vector (pcDNA3.1-AXIN1) and/or a small interfering RNA (siRNA) directed against AXIN1 (siAXIN). Following transfection, the mRNA and protein levels of AXIN1 were determined via reverse transcription-quantitative polymerase chain reaction analysis and western blotting, respectively. In addition, cell viability, apoptosis and the expression of apoptosis-associated proteins [apoptosis regulator Bax (Bax) and B-cell lymphoma (Bcl)-2] and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway proteins [phosphorylated (p)-mTOR, mTOR, p-AKT, AKT, P-70S ribosomal protein S6 (S6) and S6] were assessed. AXIN1 mRNA and protein levels were increased following transfection with pcDNA3.1-AXIN1 and decreased following transfection with siAXIN1 compared with their respective control groups. After overexpression of AXIN1, NTera2 cell viability and expression of Bcl-2, p-mTOR p-AKT and p-S6 protein was decreased, while apoptosis and Bax protein levels were increased, compared with the control group. However, there was no significant difference in AXIN1 mRNA expression, apoptosis or Bax/Bcl-2 protein expression when NTera2 cells were simultaneously transfected with pcDNA3.1-AXIN1+siAXIN1. In conclusion, the results of the present study indicate that overexpression of AXIN1 protects against TGCTs via inhibiting the PI3K/AKT/mTOR signaling pathway, suggesting that AXIN1 may be a potential target for gene therapy in TGCTs.

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Classification, epidemiology and therapies for testicular germ cell tumours

Cited by 67 publications

References 27 publications

Association Between RASSF1A Promoter Methylation and Testicular Germ Cell Tumor: A Meta-analysis and a Cohort Study

Association Between RASSF1A Promoter Methylation and Testicular Germ Cell Tumor: A Meta-analysis and a Cohort Study

Adult metastatic yolk sac tumor descending from an intra-abdominal testis: A case report and review of the literature

AXIN1 protects against testicular germ cell tumors via the PI3K/AKT/mTOR signaling pathway

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