2016
DOI: 10.1155/2016/7807596
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Classifications for Proliferative Vitreoretinopathy (PVR): An Analysis of Their Use in Publications over the Last 15 Years

Abstract: Purpose. To evaluate the current and suitable use of current proliferative vitreoretinopathy (PVR) classifications in clinical publications related to treatment. Methods. A PubMed search was undertaken using the term “proliferative vitreoretinopathy therapy”. Outcome parameters were the reported PVR classification and PVR grades. The way the classifications were used in comparison to the original description was analyzed. Classification errors were also included. It was also noted whether classifications were … Show more

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Cited by 54 publications
(47 citation statements)
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“…Retinal ischemia develops immediately after retinal detachment, followed by progressive photoreceptor apoptosis and contraction of fibrotic epiretinal membranes. 7 PVR retinal fibrosis is initiated by fibroblasts derived from RPE cells that undergo epithelial-mesenchymal transition (EMT) and begin collagen and ECM deposition, 8 orchestrated by a dysregulated panel of proinflammatory, chemotactic cytokines and mitogenic growth factors, 7 which induce an exaggerated inflammatory reaction at sites of retinal tears and detachment. 9 The early identification of inflammatory/fibrotic factors (IFF) that predict the subsequent development of PVR and direct treatments aimed at impeding/inhibiting PVR development after retinal reattachment surgery would constitute a significant clinical advance.…”
Section: Pathogenesis Of Proliferative Vitreoretinopathymentioning
confidence: 99%
“…Retinal ischemia develops immediately after retinal detachment, followed by progressive photoreceptor apoptosis and contraction of fibrotic epiretinal membranes. 7 PVR retinal fibrosis is initiated by fibroblasts derived from RPE cells that undergo epithelial-mesenchymal transition (EMT) and begin collagen and ECM deposition, 8 orchestrated by a dysregulated panel of proinflammatory, chemotactic cytokines and mitogenic growth factors, 7 which induce an exaggerated inflammatory reaction at sites of retinal tears and detachment. 9 The early identification of inflammatory/fibrotic factors (IFF) that predict the subsequent development of PVR and direct treatments aimed at impeding/inhibiting PVR development after retinal reattachment surgery would constitute a significant clinical advance.…”
Section: Pathogenesis Of Proliferative Vitreoretinopathymentioning
confidence: 99%
“…These membranes may be epi-, intra-or sub-retinal. One of the crucial points is a correct and widely accepted classification which must include intraretinal status [4,25]. In fact, PVR is characterized by epiretinal, subretinal but also intraretinal proliferation [4,26,27].…”
Section: Proliferative Vitreoretinopathy (Pvr)mentioning
confidence: 99%
“…The contraction of such membranes causes retinal distortion and tractional RD. 2 The pathogenesis of PVR includes cell migration, cell proliferation, and epiretinal membrane (ERM) formation and contraction, and the main cellular participants are retinal pigment epithelial (RPE) cells. 3,4 In RD, the blood-retinal barrier is disrupted, and the chemotactic and mitogenic activities are increased in the vitreous humor.…”
mentioning
confidence: 99%