This paper presents and compares the main methods of hazard and risk assessment for road slopes. Hazard assessment is achieved by rating several parameters such as the slope’s geometry, traffic conditions, the geology and the rockmass properties, weather conditions, historical rockfall data etc. A hazard assessment can also be executed using 2D or 3D trajectory models, by combining the frequency of a rockfall and the kinetic energy of a falling rock. Several methodologies have been developed for risk assessment, varying from simplistic approaches to comprehensive probabilistic or quantitative risk assessment methods. Finally, the most suitable methods were used in order to assess the level of hazard and risk as an example (the data from two sections of the national road at Tempi Gorge, Greece) where many rockfall events occurred in the past few years.