Abstract:Background: Bronchopulmonary dysplasia (BPD) is characterized by
impaired alveolar and microvascular development. Claudin-18 is the only
known lung-specific tight junction protein affecting alveolar epithelium
development and transdifferentiation. Objective: To explore the changes
in claudin-18 expression, alveolar epithelial cell (AEC) marker
proteins, the canonical Wnt pathway, and their possible regulatory
relationships in a hyperoxia-induced BPD rat model. Methods: The BPD
neonatal rat model was establishe… Show more
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