Claudins 1, 3, 4, 5 and 7 in esophageal cancer: loss of claudin 3 and 4 expression is associated with metastatic behavior

Takala, Heikki; Saarnio, Juha; Wiik, Heikki; Soini, Ylermi

doi:10.1111/j.1600-0463.2007.apm_656.x

Cited by 43 publications

(40 citation statements)

References 39 publications

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“…21,22 However, a study conducted in patients with surgically treated esophageal carcinomas has found that loss of claudins 3 and 4 expression was associated with the presence of distant metastases, 23 indicating again that claudin isoforms indeed may have a highly tissue specific role in carcinogenesis.…”

Section: Discussionmentioning

confidence: 99%

The diagnostic and prognostic utility of claudin expression in renal cell neoplasms

et al. 2008

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This study evaluated the expression patterns of claudins 1, 3, 4, 7, and 8 in human renal cell carcinomas and oncocytomas and correlated expression with patient prognosis. Tissue microarrays were created from paraffinembedded tissue samples from 141 patients with renal cell carcinomas or oncocytoma (90 clear cell, 22 papillary, 17 chromophobe renal cell carcinomas, and 12 oncocytomas). The staining pattern for claudins 3, 4, 7, and 8 was membranous and/or cytoplasmic, whereas claudin 1 was predominantly membranous in both nonneoplastic renal tissue and tumors. Negative to weak claudin 3 staining was predominantly detected in Fuhrman's grade 1 and 2 clear cell renal cell carcinomas (78%; P ¼ 0.016), suggesting that upregulation of claudin 3 potentially occurs concomitantly with increasing grade of clear cell renal cell carcinomas. In addition, Kaplan-Meier univariate analysis showed a significant inverse correlation between moderate to strong claudin 3 and 4 expression with overall survival in clear cell renal cell carcinomas (P ¼ 0.038 and P ¼ 0.031). Moderate to strong claudin 7 expression was significantly more common in chromophobe renal cell carcinomas (94%) than in oncocytomas (55%; P ¼ 0.041). Claudin 8 staining was moderate to strong in 92% of oncocytomas, which differentiated them from papillary and clear cell renal cell carcinomas (14 and 12%; both Po0.0001). Only negative to weak claudin 8 staining was detected in all chromophobe renal cell carcinomas, whereas there were no claudin 8 negative oncocytomas and 8% exhibited a weak staining pattern (Po0.0001). Due to their distinctive expression patterns, claudins 7 and 8 can be used as useful immunohistochemical markers for the separation of chromophobe renal cell carcinomas from oncocytomas, whereas claudins 3 and 4 may serve as indicators of prognosis in clear cell renal cell carcinomas.

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Section: Discussionmentioning

confidence: 99%

The diagnostic and prognostic utility of claudin expression in renal cell neoplasms

et al. 2008

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“…In addition, there was a tendency to reduced the claudin-1 expression in the cases with venous clarified in the esophagus extensively. In addition, only several studies examined claudins expression in the esophageal diseases including cancers (6,13,15,23,28). In this study, we demonstrated that decreased expression of claudin-1 was correlated with the recurrence status in esophageal squamous cell carcinoma, and associated with short disease-free survival and overall survival.…”

Section: Evaluation Of Immunostaining Patterns Of Claudin-1mentioning

confidence: 61%

“…Recently, two different studies have been reported; one report described that significant association was not detected between the claudin-1 expression and clinicopathological factors except for histological differentiation of the tumor (28), and another study reported that the claudin-1 expression was not associated with clinicopathological features including tumor grade, tumor size, T-stage, presence of lymph nodal and distal metastases (23). The discrepancies between our results and these studies are thought to result from the methods for the evaluation of immunoreactivities.…”

Section: Evaluation Of Immunostaining Patterns Of Claudin-1mentioning

confidence: 99%

“…The discrepancies between our results and these studies are thought to result from the methods for the evaluation of immunoreactivities. The former study evaluated the expression of claudin-1 by degree of expression (28), the latter examined it using 50% of positive expression as the cutoff point (23). We observed the deepest tumor advanced margins and used 10% as the claudin-1 cutoff point for evaluation criteria (Fig.…”

Section: Evaluation Of Immunostaining Patterns Of Claudin-1mentioning

confidence: 99%

“…The claudins have been suggested to be associated with carcinogenesis and tumor progression. Alteration of claudins has been detected in carcinomas of the esophagus (6,13,15,23,28), colorectum (14,19), and other cancers (16,21,24), suggesting that the claudins are involved in the process of carcinogenesis (20).…”

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confidence: 99%

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Decreased expression of claudin-1 is correlated with recurrence status in esophageal squamous cell carcinoma

et al. 2008

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Claudins are transmembrane proteins and major constitutes of tight junctions, and participate in the paracellular barrior and cellular connecting functions. They have been shown to be differentially regulated in malignant tumors and play a role in carcinogenesis and tumor progression. Recent studies have shown changes in expression of claudins during tumorigenesis. However, a causal relationship between claudin expression and cancer recurrent status has not been established. In this study, we examined 54 esophageal cancer cases to assess immunohistochemical expression patterns of claudin-1. Eleven (20.4%) of 54 cases had negative immunostaining for claudin-1. Decreased expression of claudin-1 was statistically correlated with recurrence status (P = 0.018). The cases with lymphatic vessel permeation showed reduced expression patterns of claudin-1 (P = 0.033). Decreased expression of claudin-1 was also correlated with short diseasefree survival (P = 0.0003) and overall survival (P = 0.0045). The results indicated that claudin-1 expression was correlated with the recurrence status and poor prognosis in esophageal cancer and claudin-1 expression may be a good indicator of recurrence in esophageal cancer.

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Developmental Profile of Claudin‐3, ‐5, and ‐16 Proteins in the Epithelium of Chick Intestine

Özden

Black

Ashwell

et al. 2010

The Anatomical Record

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Proteins in the claudin family are a main component of tight junctions and form a seal that modulates paracellular transport in intestinal epithelium. This research tests the hypothesis that claudins 3, 5, and 16 will appear in the epithelium of embryonic intestine during functional differentiation. Immunohistochemistry is utilized to explore the developmental patterns of claudin-3, -5, and -16 proteins in the epithelium of embryonic chick intestine from 9 days prior to hatching through the early post-hatch period. These claudin proteins either changed their cellular localization or first appeared around the time of hatching. After hatching, claudin-3 expression was prominent in basal-lateral regions of the epithelium along the entire villus, but was absent from crypts. Claudin-5 was expressed most strongly in the crypt and lower villus epithelium within junctional complexes, whereas immunostaining of claudin-16 was localized within goblet cells of the upper villus region. The relative mRNA levels of claudin-3, -5, and -16 showed similar patterns; transcript levels rose between 18 and 20 days of development, then dropped by 2 days post-hatch. Results of this work indicate that the claudin proteins assume their final locations within the epithelium around the time of hatching, suggesting that in addition to their known barrier and fence functions within tight junctions, these claudins may have additional roles in the differentiation and/or physiological function of chick intestine. The localization of claudin-16 to goblet cells and its distribution in the more mature cells of the upper villus region suggest an unexpected role in goblet cell maturation and mucus secretion. Anat Rec, 293:1175Rec, 293: -1183

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Claudins 1, 3, 4, 5 and 7 in esophageal cancer: loss of claudin 3 and 4 expression is associated with metastatic behavior

Cited by 43 publications

References 39 publications

The diagnostic and prognostic utility of claudin expression in renal cell neoplasms

The diagnostic and prognostic utility of claudin expression in renal cell neoplasms

Decreased expression of claudin-1 is correlated with recurrence status in esophageal squamous cell carcinoma

Developmental Profile of Claudin‐3, ‐5, and ‐16 Proteins in the Epithelium of Chick Intestine

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