CLAVANINA A BIOCONJUGADA COM NANOPARTÍCULAS DE Fe3O4 PARA ABLAÇÃO TÉRMICA DE BIOFILMES BACTERIANOS

Abstract

prophylaxis for Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae. Coated CVCs demonstrated a reduction of up to 70-90% of Gram-negative bacteria growth when compared to the (clean) control catheter. In addition, photothermal ablation (PHAB) of coated catheters already contaminated with bacterial biofilm (CVC-BF) can optionally be triggered to eliminate biofilm formations. CVC-BF cultured for 96 h after a PHAB treatment carried out for 5 min at 80 ° C resulted in the reduction of the viability of the bound bacteria in 71 to 88%.