Clear Cell Melanoma: A Cutaneous Clear Cell Malignancy

Pletneva, Maria; Andea, Aleodor A.; Palanisamy, Nallasivam; Betz, Bryan L.; Carskadon, Shannon; Wang, Min; Patel, Rajiv M.; Fullen, Douglas R.; Harms, Paul W.

doi:10.5858/arpa.2014-0307-cc

Cited by 23 publications

(21 citation statements)

References 35 publications

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“…4,121 In addition, BCC with extensive clear cell changes may raise consideration for trichilemmal carcinoma, clear cell melanoma, and other clear cell tumors presenting in the skin. 122 Rarely, BCC may display prominent, thick, fibrous stroma mimicking cylindroma. 4 Matrical differentiation may raise consideration for pilomatrical carcinoma.…”

Section: Sebaceous Carcinomamentioning

confidence: 99%

Histologic Mimics of Basal Cell Carcinoma

Stanoszek

Wang

Harms

2017

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Basal cell carcinoma (BCC) is the most common human malignant neoplasm and is a frequently encountered diagnosis in dermatopathology. Although BCC may be locally destructive, it rarely metastasizes. Many diagnostic entities display morphologic and immunophenotypic overlap with BCC, including nonneoplastic processes, such as follicular induction over dermatofibroma; benign follicular tumors, such as trichoblastoma, trichoepithelioma, or basaloid follicular hamartoma; and malignant tumors, such as sebaceous carcinoma or Merkel cell carcinoma. Thus, misdiagnosis has significant potential to result in overtreatment or undertreatment. Objective.— To review key features distinguishing BCC from histologic mimics, including current evidence regarding immunohistochemical markers useful for that distinction. Data Sources.— Review of pertinent literature on BCC immunohistochemistry and differential diagnosis. Conclusions.— In most cases, BCC can be reliably diagnosed by histopathologic features. Immunohistochemistry may provide useful ancillary data in certain cases. Awareness of potential mimics is critical to avoid misdiagnosis and resulting inappropriate management.

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Section: Sebaceous Carcinomamentioning

confidence: 99%

Histologic Mimics of Basal Cell Carcinoma

Stanoszek

Wang

Harms

2017

Archives of Pathology &Amp; Laboratory Medicine

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“…Salivary tumors may rarely occur intraosseously and when arising in the jawbones must be distinguished from odontogenic clear cell carcinoma, which may appear very similar to hyalinizing clear cell carcinoma of the salivary gland (10). Salivary lesions proximal to the skin due to tumor extension must be differentiated from a wide range of dermatologic lesions showing clear cell change including epidermal and melanocytic benign and malignant lesions (16). Benign melanocytic clear cell tumors including balloon cell nevus and cellular blue nevus along with malignant melanoma have been reported with predominant clear cell change (16).…”

Section: Discussionmentioning

confidence: 99%

“…Salivary lesions proximal to the skin due to tumor extension must be differentiated from a wide range of dermatologic lesions showing clear cell change including epidermal and melanocytic benign and malignant lesions (16). Benign melanocytic clear cell tumors including balloon cell nevus and cellular blue nevus along with malignant melanoma have been reported with predominant clear cell change (16). In addition, multiple benign and malignant adnexal eccrine and sebaceous tumors may show clear cell change (16).…”

Section: Discussionmentioning

confidence: 99%

“…Benign melanocytic clear cell tumors including balloon cell nevus and cellular blue nevus along with malignant melanoma have been reported with predominant clear cell change (16). In addition, multiple benign and malignant adnexal eccrine and sebaceous tumors may show clear cell change (16). Squamous cell carcinoma may also show predominant clear cell populations in the skin in some cases (16).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, multiple benign and malignant adnexal eccrine and sebaceous tumors may show clear cell change (16). Squamous cell carcinoma may also show predominant clear cell populations in the skin in some cases (16). Myoepithelial tumors of soft tissue may show clear cell change in 45-55% of tumors but it is rarely predominant (17).…”

Section: Discussionmentioning

confidence: 99%

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Clear cell changes in salivary gland neoplasms: A 20-year retrospective study

Woods¹,

Fitzpatrick²,

Cohen³

et al. 2017

Med Oral

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BackgroundClear cells are observed histopathologically in both benign and malignant neoplasms but their presence in salivary gland tumors has not been extensively documented.Material and MethodsWith IRB approval, the archive of the University of Florida College of Dentistry oral pathology biopsy service was retrospectively searched from 1994-2014 for all benign and malignant salivary tumors. Epidemiological data, tumor location and duration, and type of tumor were recorded. A four reviewer panel examined the original slides. Reviewers scaled each case as 0 (no clear cells present), 1 (few to focal clear cells), 2 (less than 50% clear cells), and 3 (greater than 50% clear cells).ResultsA total of 535 cases were included of which 48% of tumors displayed 0 clear cells (257/535), 31.4% (168/535) scored 1, 13.6% (73/535) scored 2, and 7% (37/535) scored 3. Of the 251 (47%) malignant neoplasms, 64% (160/251) demonstrated 0-1 clear cell change, while 36% (91/251) showed a score of 2-3. For the total 284 (53%) benign tumors, 93% (265/535) scored 0-1 and 7% (19/535) scored a 2-3 range. No statistical difference was noted for gender, age, or duration of time present in regards to presence or absence of clear cells. Statistically significant differences in clear cell presence were found between location groups, between benign and malignant diagnosis, and between specific diagnostic groups.ConclusionsThis study demonstrates the frequent presence of increased numbers of clear cells in oral salivary malignancies and highlights salivary gland differential diagnoses when presented with clear cell changes. Key words:Clear cell change, salivary tumors, benign tumors, malignant tumors.

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Two methods for proteomic analysis of formalin-fixed, paraffin embedded tissue result in differential protein identification, data quality, and cost

2015

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Formalin-fixed paraffin-embedded (FFPE) tissue is a rich source of clinically relevant material that can yield important translational biomarker discovery using proteomic analysis. Protocols for analyzing FFPE tissue by LC-MS/MS exist, but standardization of procedures and critical analysis of data quality is limited. This study compared and characterized data obtained from FFPE tissue using two methods: a urea in-solution digestion method (UISD) versus a commercially available Qproteome FFPE Tissue Kit method (Qkit). Each method was performed independently three times on serial sections of homogenous FFPE tissue to minimize pre-analytical variations and analyzed with three technical replicates by LC-MS/MS. Data were evaluated for reproducibility and physiochemical distribution, which highlighted differences in the ability of each method to identify proteins of different molecular weights and isoelectric points. Each method replicate resulted in a significant number of new protein identifications, and both methods identified significantly more proteins using three technical replicates as compared to only two. UISD was cheaper, required less time, and introduced significant protein modifications as compared to the Qkit method, which provided more precise and higher protein yields. These data highlight significant variability among method replicates and type of method used, despite minimizing pre-analytical variability. Utilization of only one method or too few replicates (both method and technical) may limit the subset of proteomic information obtained.

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Clear Cell Melanoma: A Cutaneous Clear Cell Malignancy

Cited by 23 publications

References 35 publications

Histologic Mimics of Basal Cell Carcinoma

Histologic Mimics of Basal Cell Carcinoma

Clear cell changes in salivary gland neoplasms: A 20-year retrospective study

Two methods for proteomic analysis of formalin-fixed, paraffin embedded tissue result in differential protein identification, data quality, and cost

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