Clear Cells in Cutaneous Squamous Cell Carcinoma

Corbalán-Vélez, R.; Ruiz-Maciá, J.A.; Brufau, C.; López-Lozano, J.M.; Martínez‐Barba, Enrique; Carapeto, F. J.

doi:10.1016/s1578-2190(09)70068-x

Cited by 9 publications

(12 citation statements)

References 38 publications

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“…All other cases, in which those cells occurred just focally, were not considered clear cell variant of SCC. In similar study, Corbalán-Vélez et al [9] analysed a set of 249 cutaneous SCCs and found tumor cells showing a clear cytoplasm in over half of the cases. However, only 7 lesions (3%) contained more than 75% of clear cell population.…”

Section: Discussionmentioning

confidence: 90%

“…Despite of this some authors argue [9] it may be underdiagnosed and be more frequent than the literature suggests. It is possible that etiopathogenesis of clear cells formation in SCC may be diverse and various mechanisms, e.g.…”

Section: Discussionmentioning

confidence: 94%

“…Moreover, since conventional SCCs occasionally also exhibit clear cell change, there is no consensus, from what proportion of the clear cells may a lesion be classified as clear cell SCC. Some authors [9] suggested that clear cells were generally common in SCCs, though only some lesions presented a large number of them. Among 229 cutaneous SCCs, Kuo [3] originally diagnosed merely 6 clear cell variants (2.6%), but all of them consisted almost entirely of clear cell population.…”

Section: Discussionmentioning

confidence: 99%

“…However, in a more recent retrospective study of 40 cases of SCC with clear cells [12], only two lacked glycogen accumulation in their cytoplasm. It has been speculated in certain papers [9,10] that clear cell change in cutaneous SCC may be associated with adnexal (outer root sheath) differentiation. It has been also suggested [11], that some of the published cases of clear cell SCC may arguably be classified as trichilemmal carcinoma and vice versa.…”

Section: Discussionmentioning

confidence: 99%

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Cutaneous squamous cell carcinoma in situ with extensive clear cell change – A report of two cases

Bartoš¹,

Kullová²

2017

Our Dermatol Online

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Cutaneous squamous cell carcinoma in situ with extensive clear cell change – A report of two cases

Bartoš¹,

Kullová²

2017

Our Dermatol Online

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“…33,34 Some of the type II tumors in Kuo series, showing intradermal cords of clear cells separated by compressed stroma with no clear epidermal connection, have been speculated to represent clear cell eccrine carcinomas (CCECs) of sweat gland derivation. 36 Signet ring SCC, another exceedingly rare variation of clear cell change in a SCC, was first described by Cramer and Heggeness 37 in a recurrence of an aggressive tumor which eventually led to metastases and death. 36 Signet ring SCC, another exceedingly rare variation of clear cell change in a SCC, was first described by Cramer and Heggeness 37 in a recurrence of an aggressive tumor which eventually led to metastases and death.…”

Section: Clear Cell Squamous Cell Carcinomamentioning

confidence: 99%

Cutaneous Clear Cell Neoplasms

Biswas

Mahalingam

2012

The American Journal of Dermatopathology

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Cutaneous clear cell neoplasms represent a heterogenous group of several primary and metastatic tumors with diverse histogenesis. Tumors with widespread clear cell change can seem strikingly similar under the microscope resulting in diagnostic difficulties. Although most cases are idiopathic, intracytoplasmic accumulation, artifact of tissue processing, and degenerative phenomenon have been cited as possible causes of clear cell change. An awareness of the various entities demonstrating this attribute, judicious use of ancillary techniques, and knowledge of the clinical setting are crucial to the accurate diagnosis. This review details the histological features of clear cell neoplasms of the skin with particular emphasis on the discriminating features.

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Clear Cell Squamous Cell Carcinoma of the Maxillary Gingiva Associated with PIK3CA and HRAS Mutations: Report of a Case and Literature Review

Hirose,

Shibahara,

Teramoto

et al. 2023

Head and Neck Pathol

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Background Squamous cell carcinoma (SCC) is the most common oral malignancy, and somatic mutations in some driver genes have been implicated in SCC development. Clear cell SCC (CCSCC) is a rare histological variant of SCC, and various clear cell neoplasms must be considered in the differential diagnosis of CCSCC in the oral cavity. Based on a limited number of CCSCC cases reported in the oral cavity, CCSCC is considered an aggressive variant of SCC with a poor prognosis; however, its genetic characteristics remain unknown. Methods A maxillary gingival tumor in an 89-year-old female was described and investigated using immunohistochemical staining, special staining, fluorescence in situ hybridization, and next-generation sequencing (NGS) with a custom panel of driver genes, including those associated with SCC and clear cell neoplasm development. Results Histopathological examination revealed a proliferation of atypical epithelial cells with abundant clear cytoplasm and enlarged and centrally placed round nuclei. The tumor was exophytic with deep, penetrating proliferation. The atypical clear cells were continuous with the conventional SCC cells. Immunohistochemical analysis showed that the clear cells were positive for CK AE1/AE3 and CK5/6 and nuclear-positive for p63. In contrast, the clear cells were negative for αSMA, S100, HMB45, Melan-A, CD10, and p16. p53 immunoreactivity exhibited a wild-type expression pattern. Additionally, the clear cells were positive for periodic acid-Schiff (PAS) and negative for diastase-PAS, mucicarmine, and Alcian blue. Based on these results, the diagnosis of CCSCC was confirmed. Molecular analysis of the clear cells identified PIK3CA p.E542K (c.1624G>A) and HRAS p.G12A (c.35 G>C) somatic mutations classified as oncogenic. No pathogenic variants were identified in TP53, EWSR1, AKT1, PTEN, BRAF, KRAS, NRAS, RASA1, or MAML2. Conclusions We report a case of CCSCC of the oral cavity with PIK3CA and HRAS mutations. The identification of PIK3CA and/or HRAS mutations is rare in SCC; however, both mutations are important potential targets for antitumor therapy. A detailed analysis of gene mutations in CCSCC may lead to a better understanding of its biological behavior and an improved prognosis, as well as a differential diagnosis from other clear cell neoplasms.

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Clear Cells in Cutaneous Squamous Cell Carcinoma

Cited by 9 publications

References 38 publications

Cutaneous squamous cell carcinoma in situ with extensive clear cell change – A report of two cases

Cutaneous squamous cell carcinoma in situ with extensive clear cell change – A report of two cases

Cutaneous Clear Cell Neoplasms

Clear Cell Squamous Cell Carcinoma of the Maxillary Gingiva Associated with PIK3CA and HRAS Mutations: Report of a Case and Literature Review

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