Clearance of Hepatitis B e Antigen in Patients With Chronic Hepatitis B and Genotypes A, B, C, D, and F

Livingston, Stephen; Simonetti, Josephine; Bulkow, Lisa; Homan, Chriss; Snowball, Mary; Cagle, Henry H.; Negus, Susan; McMahon, Brian J.

doi:10.1053/j.gastro.2007.08.010

Cited by 231 publications

(197 citation statements)

References 20 publications

Supporting

Mentioning

185

Contrasting

Unclassified

Order By: Relevance

“…It is not clear if these contrasting observations are actually due to gender differences or differences in infecting genotypes. Although HBV genotypes were not determined in the studies that documented higher rates of HBeAg than those found in the current study, the fact that the predominant genotype sub-type A 2 in Europe and genotype C in Asia are associated with slower HBeAg clearance than the African genotype sub-type A 1 could partly explain the higher HBeAg prevalence in those areas [33].…”

Section: Discussioncontrasting

confidence: 72%

Prevalence of hepatitis B e antigen among human immunodeficiency virus and hepatitis B virus co-infected patients in Jos, Nigeria

Iroezindu

Daniyam

Agbaji

et al. 2013

J Infect Dev Ctries

View full text Add to dashboard Cite

Introduction: Human immunodeficiency virus (HIV) negatively impacts the natural history of hepatitis B virus (HBV) infection, including replication. We determined the prevalence of HBeAg in HIV/HBV co-infected patients compared to HBV mono-infected controls and further investigated the relationship between HBeAg seropositivity and the degree of HIV-induced immunosuppression in co-infected patients. Methodology: The study design was cross-sectional. One hundred HBsAg-positive HIV-infected adults and 100 age and sex matched HBsAg-positive HIV negative controls were consecutively recruited between May and November 2010. Relevant demographic and HBVrelated information was obtained. HBeAg was assayed by semi-quantitative third generation ELISA. The HIV/HBV co-infected patients also had CD4+ cell and HIV viral load quantification measured using flow cytometry and polymerase chain reaction techniques respectively. Results: In each group, the mean age was 34 ± 8 years and the majority (61%) was female. The prevalence of HBeAg was significantly higher among co-infected patients (n = 28; 28%) than in the controls (n = 15; 15%; p = 0.03). HBeAg seropositivity was independently associated with age < 40 years (AOR = 2.83, 95% = CI 1.29-6.17) and HIV seropositivity (AOR = 2.44, 95% C.I = 1.17-5.07). The prevalence of HBeAg was significantly higher in co-infected patients with CD4 cell count < 200 cell/µL (41.3%) compared to those with 200-499 cell/µL (18.6%) and ≥500 cell/µL (9.1%), p = 0.006. Conclusion: HIV/HBV co-infected patients have a significantly higher prevalence of HBeAg than HBV mono-infected individuals. HBVinfected patients should be routinely assessed for HBeAg, especially if they are co-infected with HIV.

show abstract

Section: Discussioncontrasting

confidence: 72%

Prevalence of hepatitis B e antigen among human immunodeficiency virus and hepatitis B virus co-infected patients in Jos, Nigeria

Iroezindu

Daniyam

Agbaji

et al. 2013

J Infect Dev Ctries

View full text Add to dashboard Cite

show abstract

“…13 A genotype study in this population found five (A, B, C, D, F) of the eight genotypes of HBV in this cohort. Furthermore, differences in the outcome of HBV infection by HBV genotype have been recently elucidated in this population, such as the association between infection by genotypes F and C and HCC and delayed clearance of HBeAg in persons infected with genotype C. 14 We herein report the results of 20 years of follow-up of this HBV-infected populationbased cohort to determine if the clearance of HBsAg is associated with factors such as HBV genotype, age, and sex.…”

Section: H Epatitis B (Hbv) Infection Is a Major Worldwidementioning

confidence: 97%

Clearance of Hepatitis B Surface Antigen and Risk of Hepatocellular Carcinoma in A Cohort Chronically Infected With Hepatitis B Virus

et al. 2010

Self Cite

View full text Add to dashboard Cite

“…3A-C). Genotype B is associated with earlier HBeAg seroconversion than genotype C (45,46). Early HBeAg seroconversion typically confers a favorable outcome (47).…”

Section: Discussionmentioning

confidence: 99%

Distribution and Hepatocellular Carcinoma–Related Viral Properties of Hepatitis B Virus Genotypes in Mainland China: A Community-Based Study

Yin

Zhang

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Introduction: Hepatitis B virus (HBV) genotypes, replication status, and mutations have been associated with the risk of hepatocellular carcinoma (HCC). Our aim was to study the distribution and HCC-related viral properties of HBV genotypes/subgenotypes in Mainland China.Methods: A multistage cluster probability sampling method was applied to select 81,775 participants between 1 and 59 years at 160 national disease surveillance points. We examined hepatitis B surface antigen, HBV genotypes and subgenotypes, hepatitis B e antigen, viral load, and mutations in the PreS and core promoter regions of HBV genome.Results: HBV subgenotypes B2 (27.3%), C1 (10.7%), and C2 (58.0%) were predominant. Genotype D (D1, 80.8%) was frequent in the Uygur. We identified a new subgenotype, C9, mainly in Tibetans. Compositions of subgenotypes B2 and C1 and genotype mixture increased from the North to Central South, which was consistently associated with the increasing prevalence of hepatitis B surface antigen. Hepatitis B e antigen positivity and viral loads were higher in the young with genotype B and declined more rapidly with increasing age than those with genotype C. In contrast to G1896A, PreS deletion, T31C, T1753V, and A1762T/ G1764A were more frequent in subgenotype C2 than in subgenotype B2. A1762T/G1764A, T1753V, C1653T, and G1896A, except PreS deletion, consecutively increased with increasing age.Conclusion: HBV subgenotypes B2, C1, and C2 are endemic in Mainland China. HBV genotype C exhibits less replication activity in the young and harbors higher frequencies of the HCC-associated mutations than genotype B.Impact: These basic data could help evaluate the association of HBV variations with HCC. Cancer Epidemiol

show abstract

Clearance of Hepatitis B e Antigen in Patients With Chronic Hepatitis B and Genotypes A, B, C, D, and F

Cited by 231 publications

References 20 publications

Prevalence of hepatitis B e antigen among human immunodeficiency virus and hepatitis B virus co-infected patients in Jos, Nigeria

Prevalence of hepatitis B e antigen among human immunodeficiency virus and hepatitis B virus co-infected patients in Jos, Nigeria

Clearance of Hepatitis B Surface Antigen and Risk of Hepatocellular Carcinoma in A Cohort Chronically Infected With Hepatitis B Virus

Distribution and Hepatocellular Carcinoma–Related Viral Properties of Hepatitis B Virus Genotypes in Mainland China: A Community-Based Study

Contact Info

Product

Resources

About