Cleavage furrow-directed cortical flows bias PAR polarization pathways to link cell polarity to cell division

Ng, KangBo; Hirani, Nisha; Bland, Tom; Borrego-Pinto, Joana; Wagner, Susan; Kreysing, Moritz; Goehring, Nathan W.

doi:10.1016/j.cub.2023.08.076

Cited by 4 publications

(1 citation statement)

References 64 publications

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“…During mitosis, a cell can divide symmetrically to produce two daughter cells with an identical size and genetical properties for cell proliferation and self-renewal or asymmetrically to generate two daughter cells with a distinct size and fate for cell diversity and tissue development [ 104 , 105 , 106 ]. It is generally believed that the mitotic spindle guides the formation, positioning, and orientation of the central furrow to determine the size of two daughter cells and the symmetry of cell division [ 107 , 108 , 109 , 110 , 111 ]. Recent studies revealed that the cellular shape takes part in regulating the symmetry of cell division.…”

Section: Roles Of Osmotic Pressurementioning

confidence: 99%

Osmotic Pressure and Its Biological Implications

Zheng,

Li,

Shao

et al. 2024

IJMS

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Gaining insight into osmotic pressure and its biological implications is pivotal for revealing mechanisms underlying numerous fundamental biological processes across scales and will contribute to the biomedical and pharmaceutical fields. This review aims to provide an overview of the current understanding, focusing on two central issues: (i) how to determine theoretically osmotic pressure and (ii) how osmotic pressure affects important biological activities. More specifically, we discuss the representative theoretical equations and models for different solutions, emphasizing their applicability and limitations, and summarize the effect of osmotic pressure on lipid phase separation, cell division, and differentiation, focusing on the mechanisms underlying the osmotic pressure dependence of these biological processes. We highlight that new theory of osmotic pressure applicable for all experimentally feasible temperatures and solute concentrations needs to be developed, and further studies regarding the role of osmotic pressure in other biological processes should also be carried out to improve our comprehensive and in-depth understanding. Moreover, we point out the importance and challenges of developing techniques for the in vivo measurement of osmotic pressure.

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Section: Roles Of Osmotic Pressurementioning

confidence: 99%

Osmotic Pressure and Its Biological Implications

Zheng,

Li,

Shao

et al. 2024

IJMS

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Cell polarity: Adapting the PAR cascade to diverse cellular contexts

Yamamoto,

Motegi

2023

Current Biology

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Optimized PAR-2 RING dimerization mediates cooperative and selective membrane binding for robust cell polarity

Bland,

Hirani,

Briggs

et al. 2024

EMBO J

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Cell polarity networks are defined by quantitative features of their constituent feedback circuits, which must be tuned to enable robust and stable polarization, while also ensuring that networks remain responsive to dynamically changing cellular states and/or spatial cues during development. Using the PAR polarity network as a model, we demonstrate that these features are enabled by the dimerization of the polarity protein PAR-2 via its N-terminal RING domain. Combining theory and experiment, we show that dimer affinity is optimized to achieve dynamic, selective, and cooperative binding of PAR-2 to the plasma membrane during polarization. Reducing dimerization compromises positive feedback and robustness of polarization. Conversely, enhanced dimerization renders the network less responsive due to kinetic trapping of PAR-2 on internal membranes and reduced sensitivity of PAR-2 to the anterior polarity kinase, aPKC/PKC-3. Thus, our data reveal a key role for a dynamically oligomeric RING domain in optimizing interaction affinities to support a robust and responsive cell polarity network, and highlight how optimization of oligomerization kinetics can serve as a strategy for dynamic and cooperative intracellular targeting.

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Cleavage furrow-directed cortical flows bias PAR polarization pathways to link cell polarity to cell division

Cited by 4 publications

References 64 publications

Osmotic Pressure and Its Biological Implications

Osmotic Pressure and Its Biological Implications

Cell polarity: Adapting the PAR cascade to diverse cellular contexts

Optimized PAR-2 RING dimerization mediates cooperative and selective membrane binding for robust cell polarity

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