Cleavage Stage versus Blastocyst Stage Embryo Transfer in Oocyte Donation Cycles

Kontopoulos, George; Simopoulou, Mara; Zervomanolakis, I.; Prokopakis, Thomas; Dimitropoulos, K.; Dedoulis, Evaggelos; Grigorakis, Stylianos; Agapitou, Kristi; Nikitos, Eros; Rapani, Anna; Vlahos, Nikolaos

doi:10.3390/medicina55060293

Cited by 22 publications

(11 citation statements)

References 37 publications

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“…Moreover, the study did not limit the type of ET, including cleavage-stage or blastocyst-stage ET, or the number of transferred embryos. According to current research, there may be differences in clinical and neonatal outcomes between cleavage-stage and blastocyst-stage embryo transfers (22)(23)(24). Moreover, the effect of the number of transferred embryos on pregnancy outcome is relatively clear (25,26).…”

Section: Comparisons With Other Reportsmentioning

confidence: 99%

Comparison of Pregnancy and Neonatal Outcomes of Single Frozen Blastocyst Transfer Between Letrozole-Induction and HRT Cycles in Patients With Abnormal Ovulation

et al. 2021

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BackgroundThe use of frozen embryo transfer (FET) cycles has dramatically risen. The optimal endometrial preparation method for women undergoing FET is of utmost importance to provide the optimal chances of pregnancy. For patients with abnormal ovulation in particular, there have been few studies on FET protocols; notably, most of these studies focus only on the clinical pregnancy rate or live birth rate (LBR) and pay little attention to the regimen’s safety for offspring.MethodsIt was a retrospective cohort study. First FET cycle with a single blastocyst from whole embryo frozen IVF/ICSI at the Reproductive Center of Third Affiliated Hospital of Zhengzhou University between January 2016 and January 2020. The LBR was the primary outcome of interest. The secondary outcome measures were miscarriage rate and offspring safety, including preterm birth, low birthweight (LBW), small-for-gestational age (SGA), macrosomia and large-for-gestational age (LGA).ResultsIn total, 2782 FET cycles met the eligibility criteria for analysis. Additionally, there were 1178 singleton births from FET cycles. The clinical pregnancy rate was 58.4% in the L-FET group and 54.5% in the HRT group, with no statistical significance (P=.116). The miscarriage rate was higher in the HRT group than in the L-FET group (21.7% vs. 14.3%, P=.005). The LBR was significantly higher in the L-FET group than in the HRT group (49.6% vs. 41.7%, P=.001). Neonatal outcomes were similar between the two groups. After adjustments for confounding factors, the LBR was higher in the L-FET group (aOR 1.30, 95% CI 1.06-1.58). The rate of miscarriage was lower in the L-FET group (aOR 0.63, 95% CI 0.44-0.90).ConclusionFor patients with abnormal ovulation, the L-FET regimen has a higher LBR and lower miscarriage rate than HRT. The neonatal outcomes were similar between the two groups.

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Section: Comparisons With Other Reportsmentioning

confidence: 99%

Comparison of Pregnancy and Neonatal Outcomes of Single Frozen Blastocyst Transfer Between Letrozole-Induction and HRT Cycles in Patients With Abnormal Ovulation

et al. 2021

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“…Therefore, we suggest that the higher live birth rate we observed in the D5 ET group when all patients were analyzed together arose due to the differences in the cycle outcome in the group of patients younger than 36 years. In addition, some other studies have suggested that the rate of live birth is higher if ET in performed on day five [ 8 , 9 , 10 , 11 , 12 ], and the miscarriage rate is lower [ 11 , 13 , 14 ], but it is not clear if the cumulative LBR is also higher [ 8 ]. In contrast, other studies have indicated that there is no difference in the pregnancy or live birth rates [ 3 , 15 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

When to Transfer Embryos if There Is Only 1 or 2?

Štimpfel

Jančar

Ban-Frangež

et al. 2023

Life

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The latest reports suggest that it is better to transfer embryos to the uterus on day five of preimplantation development compared to other days of development, but it is not clear if this stands when there are only one-two embryos obtained in the cycle. Therefore, to address this issue, we performed a retrospective study of such cycles. Our study included all of the stimulated IVF/ICSI cycles performed at our institution in the period between 1 January 2004 and 31 December 2018 in which one-two embryos were obtained in the IVF/ICSI cycle and met our inclusion criteria, and we compared the data between day three and day five embryo transfer (ET). The analysis revealed that the day three ET group of patients was significantly older (p < 0.001), were administered a significantly higher dose of gonadotrophins (p = 0.015), and retrieved a lower mean number of aspirated oocytes per cycle (p < 0.001) and lower mean number of embryos (p < 0.001). The birth rate per ET was significantly higher in the day five ET group (p = 0.045) and further analysis indicated that this could be due the trend observed in a group of patients under 36 years old, while in older patients there was no such difference. To conclude, our retrospective study indicates that it might be better to perform ET on day five instead of day three when there are only one-two embryos obtained in the cycle, but probably only when patients are under 36 years old.

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“…In assisted reproductive technology cycles, embryos can be transferred during the cleavage stage and the blastocyst stage. Several meta-analyses have shown that blastocyst transfers have a higher implantation rate (IR) than cleavage-stage embryo transfers [1,2]. Single blastocyst transfer (SBT) is becoming widely popular due to tocysts and D6 high-quality blastocysts, and it has been unclear which is the better choice.…”

Section: Introductionmentioning

confidence: 99%

The pregnancy outcomes of day-5 poor-quality and day-6 high-quality blastocysts in single blastocyst transfer cycles

Zhang

Sun

et al. 2023

Clin Exp Reprod Med

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Objective: This study compared the outcomes of single blastocyst transfer cycles, using day- 5 poor-quality blastocysts and day-6 high-quality blastocysts.Methods: We analyzed 462 frozen-thawed embryo transfer (FET) cycles performed at our center from January 2014 to December 2020. The cycles were divided into two groups: a day-5 poor-quality blastocyst transfer group (group A) and a day-6 high-quality blastocyst transfer group (group B). The clinical outcomes were tested.Results: In groups A and B, respectively, the clinical pregnancy rate (CPR; 61.65% vs. 67.17%, p=0.258), implantation rate (IR; 61.65% vs. 67.17%, p=0.258), and live birth rate (LBR; 69.51% vs. 77.83%, p=0.134) showed no significant differences. Moreover, when day-3 embryo quality was considered, the CPR, IR, and LBR were also similar in group A and group B (65.71% vs. 69.46%, p=0.148; 65.71% vs. 69.46%, p=0.148; and 69.57% vs. 78.31%, p=0.216, respectively).Conclusion: The clinical outcomes of day-5 poor-quality blastocysts and day-6 high-quality blastocysts were similar, suggesting that the developmental speed of the embryo might be more important than embryo quality for the clinical outcomes of single blastocyst transfer in FET cycles.

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Cleavage Stage versus Blastocyst Stage Embryo Transfer in Oocyte Donation Cycles

Cited by 22 publications

References 37 publications

Comparison of Pregnancy and Neonatal Outcomes of Single Frozen Blastocyst Transfer Between Letrozole-Induction and HRT Cycles in Patients With Abnormal Ovulation

Comparison of Pregnancy and Neonatal Outcomes of Single Frozen Blastocyst Transfer Between Letrozole-Induction and HRT Cycles in Patients With Abnormal Ovulation

When to Transfer Embryos if There Is Only 1 or 2?

The pregnancy outcomes of day-5 poor-quality and day-6 high-quality blastocysts in single blastocyst transfer cycles

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