Cleft lip and palate: diagnosis and management

Taib, Bilal G.; Taib, Adnan; Swift, A. C.; Eeden, Simon Van

doi:10.12968/hmed.2015.76.10.584

Cited by 38 publications

(45 citation statements)

References 24 publications

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“…Taib (30) states, that approximately 35 % of cleft lip and/or palate patients have another congenital anomaly and there are 200 syndromic associations. Perrotin (18) found associated congenital defects in 26 of 62 cases (42 %).…”

Section: Discussionmentioning

confidence: 99%

Can we predict orofacial cleft in future pregnancy?

Malová¹,

Braxatorisová²,

Luha³

et al. 2016

BLL

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AIM: The aim of this thesis was not only to defi ne the frequency of all orofacial clefts and their particular types, but also to determine the sex of an embryo or fetus and detect associated developmental and chromosomal abnormalities. Approximately one third of orofacial clefts are a part of chromosomal syndromes. MATERIALS AND METHODS: Retrospective morphological and cytogenetic study of 43 cases of different types of orofacial clefts between 1992-2014 from miscarriages (spontaneous abortions) and premature births. RESULTS: Associated abnormalities were found in 34 cases. Most of the anomalies were skeletal anomalies (29), NTD (24) and anomalies of the abdominal wall (9). Most associated anomalies were found in the R III group (93.3 %). Eleven of the successfully cultivated cases (26 %) had a normal karyotype and in 14 of the cases (32 %), numerical or unbalanced structural chromosomal aberrations were found. CONCLUSION: Our data did not show that isolated clefts were not associated with a higher risk of chromosomal aberrations. Higher percentage of chromosomal aberrations found in isolated clefts in our pool can be explained by the age of the embryos and fetuses -usually between day 43 and week 12. It is nearly impossible to diagnose some associated congenital defects at such an early age. Thanks to the morphological and cytogenetic analysis of embryos and fetuses with orofacial cleft, it is possible to estimate if not determine the etiologic factor which infl uenced the miscarriage. Additionally, in the case of birth defects, the prognosis for future pregnancy can be offered, which is important information for gynecologist and clinical geneticist (Tab. 5, Fig. 5, Ref. 31). Text in PDF www.elis.sk.

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Section: Discussionmentioning

confidence: 99%

Can we predict orofacial cleft in future pregnancy?

Malová¹,

Braxatorisová²,

Luha³

et al. 2016

BLL

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“…Yeni doğan bebeklerde orta kulak boşluğu zaten bakteriler için mükemmel besi yeri görevi gören embriyona bağ dokusuyla doludur ve bebeğin bağışıklık sistemi henüz bu tehditlere karşı yeterli savunmayı gerçekleştirebilecek kapasiteye ulaşmamıştır. 24 Patojen mikroorganizmalara karşı savunmasız olan orta kulak boşluğu devamlı enfeksiyöz tehdite maruz kalınca otitis media insidansı da artmaktadır. Her iki durumda da uzun süre devam eden otitis media değişen derecelerde duyma kaybına neden olur.…”

Section: Orta Kulak Enfeksiyonları (Otitis Media)unclassified

Congenital and developmental problems seen in patients with cleft lip and/or palate

Tunçer¹,

Yılmaz²

2018

Yeditepe J Dent

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Dudak ve/ya damak yarıkları (DDY) kraniyofasiyal bölgenin en sık görülen doğumsal defektlerinden biridir. Yumuşak ve sert dokuları her üç boyutta etkileyen bu anomali, büyüme ve kraniyofasiyal yapıların hareketiyle dördüncü bir boyut da kazanır. Anne karnında teşhis edildiği an itibariyle başlayan, oral bölgeyle sınırlı görünüp vücudun diğer pek çok bölgesini etkileyen bu anomali hem DDY'li birey hem de aile için zorlu ve uzun bir süreçtir. Bu bireylerde sıklıkla rastlanan problemler; beslenme problemleriyle ilişkili büyüme ve gelişim anomalileri, solunum problemleri, orta kulak enfeksiyonları, konuşma ve öğrenme problemleri, normalden sapmış nazomaksiller, pterygomaksiller ve farengeal anatomi ile ilişkili problemler, maksiller sinüs oluşumunda görülen problemler ve sinüzit, dental problemler, tükürük yapısındaki farklılıklar, oral ve nazal halitozis, oral kandida kolonizasyonu, oral hijyen ve periodontal sağlıkla ilgili problemler, psikolojik ve nörolojik problemler ve DDY'nin eşlik ettiği diğer anomalilerdir. Bireyin gerek yaşamsal fonksiyonlarını gerekse de hayat kalitesini önemli ölçüde etkileyen bu problemlere yönelik doğru ve etkili bir tedavi yaklaşımı sunabilmek için hekimin görülmesi muhtemel bütün doğumsal ve gelişimsel anomalilere hâkim olması gerekir. Anahtar kelimeler:Dudak yarığı, tavşan dudak, damak yarığı, doğumsal anomaliler, gelişimsel anomaliler SUMMARY Cleft lip and/or palate (CL/P) is one of the most frequently-seen congenital malformations of the craniofacial region. Affecting both hard and soft tissues in all 3 dimensions, CL/P achieves a fourth dimension with growth and displacement of the craniofacial structures. Although it seems to be limited with the orofacial region, it affects many other body parts and is a very compelling and lasting period starting with the prenatal diagnosis. Common problems encountered in these patients are growth and developmental anomalies associated with nutritional problems, respiratory problems, otitis media, speech and learning disorders, problems related with abnormal nasomaxillary, pterygomaxillary and pharengeal anatomies, maxillary sinus malformation and sinusitis, dental problems, differences in saliva composition, oral and nasal halitosis, oral candidiasis, problems with oral hygiene and periodontal health, psychological and neurological problems, and CL/P-accompanied anomalies. Therefore, it is mandatory to have a solid grasp of all the potential congenital and developmental anomalies affecting the CL/P patient's quality of life besides vital functions, in order to offer an accurate and effective health service.

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“…Normal mandibular growth results in a prenormal dental arch relation [2]. The retrognathic maxilla creates tendency for over-rotation of mandible resulting in pseudoprognatism, loss of facial height, class III skeletal and dental malocclusion with characteristic facial appearance and need for surgery and psychological support in teenage years [3]. Discrepancy between maxilla and mandible combined with increased vertical space between maxillary and mandibular teeth may also affect normal speech [4].…”

Section: Introductionmentioning

confidence: 99%

“…However, when optimal occlusal relationship cannot be achieved, orthodontic treatment combined with surgery is recommended. According to some studies, up to 80% CLP patients require orthognathic surgery [3]. Orthognathic surgery, combined with orthodontics, aims to improve facial and dental aesthetics and to achieve good long-term prognosis [5].…”

Section: Introductionmentioning

confidence: 99%

“…Risk of velopharyngeal insufficiency is present in advancement with both CO and DO [7]. Amount of maxillary advancement has to be limited for a patient with nasal speech [1] as velopharyngeal insufficiency affects resonance by creating nasal air escape in speech, affecting intelligibility and confidence of affected patients [3]. Thus, maxillary advancement affects facial aesthetics, function (speech and occlusion), and consequently also quality-of-life (QoL) of patients.…”

Section: Introductionmentioning

confidence: 99%

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