Cleft lip and palate are congenital malformations with the highest prevalence worldwide, its etiology is multifactorial and produces different dental anomalies and occlusal alterations. The present study aims to review the literature to gather information on the association of cleft lip and cleft palate in the development of occlusal disorders that cause problems in swallowing, speech, feeding and breathing. A descriptive review was performed with a qualitative approach of the literature, including original articles, systematic reviews and bibliographic reviews published after 2019. Once the information was analyzed, it is evident that congenital malformations play an important role in the establishment of occlusal alterations that affect the correct development of the stomatognathic system. In conclusion, cleft lip and palate have a negative impact on facial and occlusal structures.