Cleistanthin A causes DNA strand breaks and induces apoptosis in cultured cells

Pradheepkumar, Chhalliyil Prabhakaran; Panneerselvam, N.; Shanmugam, G.

doi:10.1016/s1383-5718(99)00179-5

Cited by 37 publications

(28 citation statements)

References 16 publications

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“…These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/data_request/cif. 13 C NMR spectra was recorded with a Bruker 500.13 MHz spectrometer operating at 125 MHz.…”

Section: Methodsmentioning

confidence: 99%

“…1 H chemical shift was referenced to CHCl 3 at δ = 7.27 ppm, whereas 13 Extraction and Isolation: Dried and ground leaves (0.9 kg) of C. indochinensis were extracted thrice by stirring each time with 3 L of CH 2 Cl 2 at room temperature for 1 d. The CH 2 Cl 2 solution was concentrated in vacuo to dryness, and the residue (28.5 g) was purified by chromatography on a silica gel column (5-100 % EtOAc in n-hexane, 3.5 L) to give 15 fractions. Fraction 2 (11.1 g) was subjected to column chromatography on silica gel (n-hexane), yielding 7 subfractions.…”

Section: Methodsmentioning

confidence: 99%

“…[1,[4][5][6][7][8][9] Among them, cleistanthin A and cleistanthin B isolated from C. collinus were found to exhibit preferential cytotoxicity in several tumor cell lines. [11][12][13] In our screening program on the flora of Vietnam, the plant C. indochinensis Merr. ex Croiz was collected from Nghe An province.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cleistanone: A Triterpenoid from Cleistanthus indochinensis with a New Carbon Skeleton

Thanh¹,

Pham²,

Nguyen³

et al. 2011

Eur J Org Chem

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Cleistanone (1) was isolated from the leaves of Cleistanthus indochinensis and features a new type of triterpenoid carbon skeleton. Its structure was confirmed by X‐ray diffraction analysis. A plausible biosynthetic pathway was proposed for 1 and is thought to proceed through a Wagner–Meerwein rearrangement. Cleistanone (1) was found to show cytotoxic activity against human oral epidermoid carcinoma KB cells.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Cleistanone: A Triterpenoid from Cleistanthus indochinensis with a New Carbon Skeleton

Thanh¹,

Pham²,

Nguyen³

et al. 2011

Eur J Org Chem

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“…They possess anti-oxidant and anti-cancer activities [156]. Various lignans effectively inhibit CML cell proliferation and induced apoptosis (Figure 3) (Table 6) [157][158][159][160][161][162][163].…”

Section: Lignansmentioning

confidence: 99%

Natural Products for Treatment of Chronic Myeloid Leukemia

Khajapeer¹,

Baskaran²

2016

Anti-Cancer Drugs - Nature, Synthesis and Cell

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Chronic myeloid leukemia (CML) is a hematological malignancy that arises due to reciprocal translocation of 3′ sequences from c-Abelson (abl) protooncogene on chromosome 9 with 5′ sequence of truncated break point cluster region (bcr) to chromosome 22. The fusion gene product BCR-ABL, a functional oncoprotein p210, is a constitutively activated tyrosine kinase that activates several cell proliferative signaling pathways. BCR-ABL-specific tyrosine kinase inhibitors (TKIs) such as imatinib, nilotinib and ponatinib potently inhibit CML progression. However, drug resistance owing to BCR-ABL mutations and overexpression is still an issue. Natural products are chemical compounds or substances produced by living organisms. They are becoming an important research area for cancer drug discovery due to their low toxicity and cost-effectiveness. Several lines of evidence show that many NPs such as alkaloids, flavonoids, terpenoids, polyketides, lignans and saponins inhibit CML cell proliferation and induce apoptosis. NPs not only differentiate CML cells into monocyte/erythroid lineage but also can reverse the multi-drug resistance (MDR) in CML cells. In this chapter, we review the anti-CML activity of various NPs.

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“…Daurinol is isolated from a traditional ethno-pharmacologic plant, Haplophyllum dauricum, which has historically been used to treat tumors in Russia (33). Antiproliferative activities of arylnaphthalene lignans against various human cancer cells have been reported, but the molecular mechanism of their antiproliferative effects is still poorly understood (34)(35)(36). Daurinol displayed strong antitumor activity without any significant adverse effects (36).…”

Section: Introductionmentioning

confidence: 99%

Daurinol Enhances the Efficacy of Radiotherapy in Lung Cancer via Suppression of Aurora Kinase A/B Expression

Woo

Kang

Shin

et al. 2015

Molecular Cancer Therapeutics

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The aurora kinases constitute one family of serine/threonine kinases whose activity is essential for mitotic progression. The aurora kinases are frequently upregulated in human cancers and are associated with sensitivity to chemotherapy in certain ones. In the present study, we investigated whether aurora kinases could be a target to overcome radioresistance or enhance the radiosensitivity of lung cancer. For that purpose, we determined the therapeutic potential of daurinol, an investigational topoisomerase inhibitor, alone and in combination with radiation, by observing its effect on aurora kinases. Daurinol decreased cell viability and proliferation in human colon and lung cancer cells. Gene expression in daurinol-treated human colon cancer cells was evaluated using RNA microarray. The mRNA expression of 18 genes involved in the mitotic spindle check point, including aurora kinase A (AURKA) and aurora kinase B (AURKB), was decreased in daurinol-treated human colon cancer cells as compared with vehicle-treated cells. As expected, radiation increased expression levels of AURKA and AURKB. This increase was effectively attenuated by siRNAs against AURKA and AURKB, which suppressed cell growth and increased apoptosis under radiation. Furthermore, the expression of AURKA and AURKB was suppressed by daurinol in the presence or absence of radiation in colon and lung cancer cells. Daurinol alone or in combination with radiation decreased lung cancer growth in xenograft mouse models. Our data clearly confirm the antitumor and radiosensitizing activity of daurinol in human lung cancer cells through the inhibition of AURKA and AURKB. Mol Cancer Ther; 14(7); 1693-704. Ó2015 AACR.

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Cleistanthin A causes DNA strand breaks and induces apoptosis in cultured cells

Cited by 37 publications

References 16 publications

Cleistanone: A Triterpenoid from Cleistanthus indochinensis with a New Carbon Skeleton

Cleistanone: A Triterpenoid from Cleistanthus indochinensis with a New Carbon Skeleton

Natural Products for Treatment of Chronic Myeloid Leukemia

Daurinol Enhances the Efficacy of Radiotherapy in Lung Cancer via Suppression of Aurora Kinase A/B Expression

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