Clemastine as a Main Sedative Drug in Colonoscopy

Abstract

Background: Colonoscopy is the endoscopic examination of the large bowel and the distal part of the small bowel with a CCD camera or a fiber-optic camera on a flexible tube passed through the anus. It can provide a visual diagnosis. Methods: In this study, clemastine plus fentanyl was compared with fentanyl plus midazolam in analgesia during colonoscopy. Patients were monitored for pain and hemodynamic changes. The mean age in the group treated with clemastine was 52 years and in the group treated with midazolam was 54 years. There were 56 males and 35 females in the study. There was no significant difference in gender in the two groups. Systolic blood pressure was 109.9 mmHg before and 109.35 mmHg after clemastine administration, which showed no significant difference. Results: Diastolic blood pressure was 72.2 mmHg before and 73.7 mmHg after clemastine administration, which showed no significant difference. No change in mean pulse rate (PR) was seen (84/min before and after clemastine administration). In the group receiving midazolam, systolic and diastolic blood pressure changes were not significant, but changes in PR and arterial oxygen saturation were significantly different. Meanwhile, the two groups had a significant lower pain level after colonoscopy in the group receiving clemastine compared to midazolam. Conclusion: Based on the results of the present study, clemastine can be used as a main drug for sedation during colonoscopy.