Clerodendrum serratum (L.) Moon. – A review on traditional uses, phytochemistry and pharmacological activities

Patel, Jagruti J.; Acharya, Sanjeev; Acharya, Niyati

doi:10.1016/j.jep.2014.03.071

Cited by 71 publications

(42 citation statements)

References 51 publications

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“…Thus, it is proved that the EFSD prevents the diabetic associated kidney damage and reduces the complication associated with increased oxidative stress. This could be due to the positive role of flavonoids and phenolics in free radical scavenging and antioxidant activities by activating the detoxification mechanism to prevent the oxidative stress associated cellular damage (Patel et al 2014;Abdelaziz et al 2015).…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic, antihyperlipidaemic, and antioxidant activity of Syzygium densiflorum fruits in streptozotocin and nicotinamide-induced diabetic rats

Gopinath

Muthusamy

Chellappan

et al. 2015

Pharmaceutical Biology

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Context Syzygium densiflorum Wall. ex Wight & Arn (Myrtaceae) has been traditionally used by local tribes of the Nilgiris, Tamil Nadu, India, for the treatment of diabetes, however, no definitive experimental studies are available. Objective This study investigates the antidiabetic, antihyperlipidaemic and antioxidant activities of ethanol extract of S. densiflorum (EFSD) fruits in streptozotocin (STZ) and nicotinamide (NA)-induced diabetic rats. Materials and methods Acute oral toxicity and oral glucose tolerance were assessed in normal rats. The antidiabetic, antihyperlipidaemic and antioxidant activities were investigated in STZ À NAinduced diabetic rats. Diabetic rats were orally administered with glibenclamide (10 mg/kg b.wt), EFSD (200, 400 and 800 mg/kg b.wt) for 28 d. Further, changes in the blood glucose level (BGL), biochemical parameters, antioxidants were observed and histology of pancreas was performed.Results No toxicity and lethality were observed. Results of the following parameters are represented by treated versus disease control (STZ + NA) groups. BGL (161.33 ± 22.8 versus 476.17 ± 56.58 mg/dl), glycosylated haemoglobin (5.285 ± 0.19 versus 8.05 ± 0.55%), urea (40.32 ± 1.96 versus 75.37 ± 2.91 mg/dl), uric acid (1.2 ± 0.07 versus 2.16 ± 0.05 mg/dl), total cholesterol (89.3 ± 5.14 versus 139.7 ± 5.95 mg/dl) and triglycerides (79.65 ± 2.52 versus 108.9 ± 3.61 mg/dl) were significantly decreased, whereas haemoglobin (11.75 ± 0.73 versus 7.95 ± 0.42 g/dl), high-density lipoprotein cholesterol (14.2 ± 1.11 versus 6.97 ± 0.84 mg/dl), total protein (45%) and liver glycogen (87%) were significantly increased in EFSD-treated diabetic group. Significant changes were observed in the enzymatic and non-enzymatic antioxidants in EFSDtreated groups (p50.001). Histopathological examination showed the regeneration of b-cells in Islets of Langerhans. Conclusion This study confirms the antidiabetic, antihyperlipidaemic and antioxidant activities of S. densiflorum fruits. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 99%

Antidiabetic, antihyperlipidaemic, and antioxidant activity of Syzygium densiflorum fruits in streptozotocin and nicotinamide-induced diabetic rats

Gopinath

Muthusamy

Chellappan

et al. 2015

Pharmaceutical Biology

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“…Hasil simulasi menyimpulkan bahwa lima senyawa yaitu apigenin 7-glucoside, hispidulin, scutellarein-7-O-beta-D-glucuronate, acteoside dan verbascoside memiliki potensi berikatan dengan target protein kanker dan menimbulkan efek terapi. Interaksi ikatan maksimum dengan 17 target obat kanker ditunjukan oleh apigenin 7-glucoside dan hispidulin (Gogoi et al 2017) Tanaman genus Clerodendrum secara tradisional dimanfaatkan sebagai antitumor (Patel et al 2014) …”

Section: Pendahuluanunclassified

“…Secara tradisional tanaman ini digunakan sebagai antitumor (Patel et al 2014). Data ilmiah dalam tulisan ini membuktikan bahwa tanaman genus Clerodendrum memiliki efek sitotoksik sehingga berpotensi untuk dikembangkan sebagai sumber senyawa aktif baru dengan efek antikanker.…”

Section: Aktivitasunclassified

Anticancer Activity Of Plant Genus Clerodendrum (Lamiaceae): A Review

Kalonio¹,

Hendriani

Barung

2017

Trad.Med.J

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ABSTRAK Tanaman dari genus Clerodendrum (Lamiaceae) tersebar luas di daerah tropis dan subtropis. Tanaman dari genus ini digunakan secara empiris maupun ilmiah sebagai antiinflamasi, antidiabetes, antimalaria, antivirus, antihipertensi, hipolipidemik, antioksidan, dan (WHO 2017). Tingginya kasus kanker baru dan angka kematian akibat kanker dapat disebabkan oleh faktor resiko perilaku dan pola makan. Faktor-faktor tersebut adalah indeks massa tubuh yang tinggi, kurangnya konsumsi sayur dan buah, kurangnya aktivitas fisik, merokok dan konsumsi alkohol yang berlebihan (Pusdatin 2015). Berbagai upaya dilakukan untuk mengobati kanker, termasuk didalamnya menggunakan

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“…These phytochemical screening included tests for alkaloids, tannins, steroid, glycoside, flavonoids, saponins, carbohydrates, terpenoids and proteins [18] . Heavy metal analysis was performed using Perkin Elmer AAS-200 instrument.…”

Section: Qualitative Phytochemical Investigation and Heavy Metal Analmentioning

confidence: 99%

“…In this relation, the comparative phytochemical evaluation of Amrtadi churna and its individual ingredients in solvents of different polarity are carried out. Phytoconstituents like phenolic, flavonoids, tannins etc., have been previously found to be useful in the management of antiulcer [18] . The presence of the said constituents in Amrtadi churna may be responsible for its clinical usefulness as antiulcer agent.…”

Section: Physicochemical Analysis Of Amrtadi Churnamentioning

confidence: 99%

Analytical Standards of Amrtadi Churna: A Classical Ayurvedic Formulation

Mukhi¹,

Bose²,

Ray³

et al. 2017

Journal of Pharmaceutical Sciences

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The present investigation was carried out to characterise the Ayurvedic preparation, Amrtadi churna, a polyherbal formulation comprising of three ingredients, on the basis of the pharmacognostic, physicochemical, pharmaceutical, microbiological, toxicological, spectroscopic and chromatographic parameters to confirm its identity, quality and purity. The results obtained in this evaluation demonstrated the potential to identify each and every ingredient in Amrtadi churna. The parameters documented in this paper could be used for the preparation of the monograph on quality standards for Amrtadi churna to maintain its batch-to-batch consistency. This document could also be utilised for Fourier transform infrared spectroscopy and high performance thin layer chromatography based rapid authentication for the formulation.

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Clerodendrum serratum (L.) Moon. – A review on traditional uses, phytochemistry and pharmacological activities

Cited by 71 publications

References 51 publications

Antidiabetic, antihyperlipidaemic, and antioxidant activity of Syzygium densiflorum fruits in streptozotocin and nicotinamide-induced diabetic rats

Antidiabetic, antihyperlipidaemic, and antioxidant activity of Syzygium densiflorum fruits in streptozotocin and nicotinamide-induced diabetic rats

Anticancer Activity Of Plant Genus Clerodendrum (Lamiaceae): A Review

Analytical Standards of Amrtadi Churna: A Classical Ayurvedic Formulation

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