Click-derived multifunctional metal complexes for diverse applications

Abstract

Numerous complex architectures are possible through Click reactions which display high specificity, flexibility and modularity. Click chemistry has addressed many challenges in the biomedical field, including drug delivery and theranostics.

Regioselective Synthesis of Unsymmetrical Vicinal Diamines via Azidoimination of Alkenes with TMSN3 and Ketimines

“…This protocol showcases exclusive regioselectivity on account of the different reactivities compared to the iminyl radical with the N 3 radical. Remarkably, the azido (N 3 ) groups are crucial scaffolds of numerous valuable molecules that are extensively applied in drug discovery, chemical biology, and synthetic chemistry, in particular, the unique reactivity of organoazides permits their use in bioconjugation with click chemistry . Moreover, either imine or azido groups of the target products could be conveniently and orthogonally unmasked to release the primary amine entity, thereby potentially boosting downstream design of lead compounds for drug discovery.…”