Click Functionalization of Sol–Gel Materials

Perdoor, Shridevi Shenoi; Noureddine, Achraf; Dubois, Fabien; Man, Michel Wong Chi; Cattoën, Xavier

doi:10.1007/978-3-319-19454-7_95-1

Cited by 6 publications

(2 citation statements)

References 117 publications

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“…Mesoporous silica functionalized with mercapto groups (-SH) and amine groups (-NH 2 ) show a specific affinity for specific metal ions [28][29][30][31]. In general, increasing the ligand group content in adsorbent materials is thought to significantly improve the adsorption efficiency [32][33][34].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Mesoporous Silica Adsorbent Modified with Mercapto–Amine Groups for Selective Adsorption of Cu2+ Ion from Aqueous Solution

2022

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In a sol–gel co-condensation, a mesoporous silica hybrid integrated with (3-mercaptopropyl)trimethoxysilane (TMPSH) was prepared and then reacted with allylamine via a post-surface functionalization approach. Approximately 15 mol% of TMSPSH was introduced into the mesoporous silica pore walls along with tetraethyl orthosilicate. The mercapto ligands in the prepared mesoporous silica pore walls were then reacted with allylamine (AM) to form the mercapto–amine-modified mesoporous silica adsorbent (MSH@MA). The MSH@MA NPs demonstrate highly selective adsorption of copper (Cu2+) ions (~190 mg/g) with a fast equilibrium adsorption time (30 min). The prepared adsorbent shows at least a five times more efficient recyclable stability. The MSH@MA NPs adsorbent is useful for selective adsorption of Cu2+ ions.

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Section: Introductionmentioning

confidence: 99%

Synthesis of Mesoporous Silica Adsorbent Modified with Mercapto–Amine Groups for Selective Adsorption of Cu2+ Ion from Aqueous Solution

2022

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“…In this study, we evaluate the potential of our novel organic@silicate core–shell NPs for two-photon in vivo fluorescence imaging. The CuAAC (copper catalyzed azide to alkyne cycloaddition) click reaction was used to graft PEG chains onto the core–shell NPs to enhance their colloidal stability and “stealth” in blood by minimizing protein adsorption and opsonization. − Classical DLS experiments coupled with small-volume DLS (confocal geometry) was used to characterize the colloidal stability of the NPs in different biological media with increasing complexity, starting with simulated body fluid (SBF) and various plasma proteins in increasing concentrations. Finally, we present, two-photon fluorescence properties in solution to demonstrate the potential of these NPs for two-photon fluorescence imaging both in vitro and in vivo.…”

Section: Introductionmentioning

confidence: 99%

Ultrabright Silica-Coated Organic Nanocrystals for Two-Photon In Vivo Imaging

Perdoor

Dubois

Barbara

et al. 2020

ACS Appl. Nano Mater.

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Herein, we demonstrate the potential of ultrabright fluorescent silica-coated organic nanocrystals for two-photon in vivo imaging. These unique nanoparticles (NPs) containing a crystalline core of small push-pull dipolar dye are specifically designed to exhibit two-photon absorption for 2 fluorescence imaging. The NPs can be easily functionalized using click chemistry in pure water, with preservation of the organic core. A novel small-volume DLS technique was used to evaluate the effect of PEGylation on the colloidal stability of the NPs in complex media containing salts and proteins, mimicking the composition of blood serum. The potential of these bright red-emitting NPs for two-photon fluorescence imaging is demonstrated both in vitro and in vivo.

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Mesoporous Silica and Organosilica Nanoparticles: Physical Chemistry, Biosafety, Delivery Strategies, and Biomedical Applications

Croissant

Fatieiev

Almalik

et al. 2017

Adv Healthcare Materials

472

349

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Predetermining the physico-chemical properties, biosafety, and stimuli-responsiveness of nanomaterials in biological environments is essential for safe and effective biomedical applications. At the forefront of biomedical research, mesoporous silica nanoparticles and mesoporous organosilica nanoparticles are increasingly investigated to predict their biological outcome by materials design. In this review, it is first chronicled that how the nanomaterial design of pure silica, partially hybridized organosilica, and fully hybridized organosilica (periodic mesoporous organosilicas) governs not only the physico-chemical properties but also the biosafety of the nanoparticles. The impact of the hybridization on the biocompatibility, protein corona, biodistribution, biodegradability, and clearance of the silica-based particles is described. Then, the influence of the surface engineering, the framework hybridization, as well as the morphology of the particles, on the ability to load and controllably deliver drugs under internal biological stimuli (e.g., pH, redox, enzymes) and external noninvasive stimuli (e.g., light, magnetic, ultrasound) are presented. To conclude, trends in the biomedical applications of silica and organosilica nanovectors are delineated, such as unconventional bioimaging techniques, large cargo delivery, combination therapy, gaseous molecule delivery, antimicrobial protection, and Alzheimer's disease therapy.

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Click Functionalization of Sol–Gel Materials

Abstract: International audienc

Cited by 6 publications

References 117 publications

Synthesis of Mesoporous Silica Adsorbent Modified with Mercapto–Amine Groups for Selective Adsorption of Cu2+ Ion from Aqueous Solution

Synthesis of Mesoporous Silica Adsorbent Modified with Mercapto–Amine Groups for Selective Adsorption of Cu2+ Ion from Aqueous Solution

Ultrabright Silica-Coated Organic Nanocrystals for Two-Photon In Vivo Imaging

Mesoporous Silica and Organosilica Nanoparticles: Physical Chemistry, Biosafety, Delivery Strategies, and Biomedical Applications

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