Click functionalized biocompatible gadolinium oxide core-shell nanocarriers for imaging of breast cancer cells

Siribbal, Shifaa M.; Ilyas, Shaista; Renner, Alexander M.; Iqbal, Sumiya; Vázquez, Sergio Muñoz; Moawia, Abubakar; Valldor, Martin; Hussain, Muhammad Sajid; Schomäcker, K.; Mathur, Sanjay

doi:10.1039/d2ra00347c

Cited by 5 publications

(5 citation statements)

References 58 publications

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“…The intense peak at 1708 cm –1 in the pure DOTA molecule is attributed to the CO vibration of four carboxy functions that was found to be shifted toward 1596 cm –1 in the spectrum of conjugated DOTA. The signal at 1507 cm –1 in pure DOTA is shifted to 1488 cm –1 in DOTA-conjugated particles and can be attributed to aromatic C–C stretch vibration (Figure b). , In order to facilitate a systematic comparative analysis of surface functional groups and their corresponding alterations, FTIR spectra of the pure compounds have been depicted in Figure S3, elucidated in the Supporting Information.…”

Section: Resultsmentioning

confidence: 99%

“…The signal at 1507 cm −1 in pure DOTA is shifted to 1488 cm −1 in DOTA-conjugated particles and can be attributed to aromatic C−C stretch vibration (Figure 2b). 40,41 In order to facilitate a systematic comparative analysis of surface functional groups and their corresponding alterations, FTIR spectra of the pure compounds have been depicted in Figure S3, elucidated in the Supporting Information.…”

Section: ■ Resultsmentioning

confidence: 99%

“…To covalently attach DOTA as a chelator for certain radiometals onto the surface of FA-PDA@mSiO 2 particles, we followed the protocol described by Siribbal and Ilyas et al with minor modifications. 40 10 mg of FA-PDA@mSiO 2 particles were redispersed in 2 mL of Na 2 CO 3 -buffer (pH 9)/ultrapure water (1/1). 2 mg of DOTA was dissolved in 2 mL of Na 2 CO 3 -buffer and added dropwise to the FA@PDA@mSiO 2 dispersion under a stirring rate of 400 rpm.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

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Validation of Dual-Action Chemo-Radio-Labeled Nanocarriers with High Efficacy against Triple-Negative Breast Cancer

Ilyas,

E. M. Sahnoun,

Szymura

et al. 2023

ACS Appl. Mater. Interfaces

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Identification and selectivity of molecular targets with prolonged action for difficult-to-target cancer such as triple-negative breast cancer (TNBC) represent a persisting challenge in the precision delivery of therapeutics. In the quest to target undruggable sites, this study validates the bioavailability of polydopamine-sealed mesoporous silica nanocarriers (PDA-mSiO 2 ) for in vivo drug delivery to TNBC. For controlled transport and release, the chemotherapeutic drug doxorubicin was encapsulated in mSiO 2 nanocarriers coated with a PDA layer serving as a stimuli-responsive gatekeeper or seal. For unifying targeting and treatment modalities, these nanocarriers were covalently conjugated to a macrocyclic chelator (DOTA) and folate (FA-mSiO 2. ) that enabled incorporation of radionuclides and identification of FR Alpha (FolRα) receptors present on TNBC cells. The robust chemical design of FA-and DOTA-functionalized PDA-coated mSiO 2 nanocarriers constitutes mild reaction conditions to avoid the loss of surface-bound molecules. The radiolabeling studies with the theranostic pair 68 Ga and 177 Lu showed quantitative trends for radiochemical efficacy and purity. Nanocarriers equipped with both radiolabels and affinity ligands were optimally stable when incubated with human serum for up to 120 h ( 177 Lu), demonstrating hydrophilicity with a partition coefficient (log P) of −3.29 ± 0.08. Specifically, when incubated with TNBC cells, the cells received significant FA-mSiO 2 carriers, demonstrating efficient carrier internalization and time-dependent uptake. Moreover, in vivo results visualize the retention of drug-filled carriers at the tumor sites for a long time, which holds promise for therapeutic studies. This research work demonstrates for the first time the successful dual conjugation of nanocarriers through the colocation of radionuclides and anticancer drugs that is promising for both live molecular imaging and enhanced therapeutic effect for TNBC.

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Section: Resultsmentioning

confidence: 99%

Section: ■ Resultsmentioning

confidence: 99%

Section: ■ Experimental Sectionmentioning

confidence: 99%

See 1 more Smart Citation

Validation of Dual-Action Chemo-Radio-Labeled Nanocarriers with High Efficacy against Triple-Negative Breast Cancer

Ilyas,

E. M. Sahnoun,

Szymura

et al. 2023

ACS Appl. Mater. Interfaces

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“…Ruthenium (Ru-II) ( Rahman et al, 2018 ; Chen et al, 2020 ) and Gadolinium (Gd-III) ( Siribbal et al, 2022 ; Zhang et al, 2023 ) are metals with different degrees of oxidation. In living organisms, Ru-II and Gd-II can attach to transferrin and albumin, leading to programmed cancer cell death.…”

Section: Novel Nano-drug Delivery Systemsmentioning

confidence: 99%

Advances in Doxorubicin-based nano-drug delivery system in triple negative breast cancer

Zeng,

Luo,

Gan

et al. 2023

Front. Bioeng. Biotechnol.

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Triple positive breast cancer (TPBC) is one of the most aggressive breast cancer. Due to the unique cell phenotype, aggressiveness, metastatic potential and lack of receptors or targets, chemotherapy is the choice of treatment for TNBC. Doxorubicin (DOX), one of the representative agents of anthracycline chemotherapy, has better efficacy in patients with metastatic TNBC (mTNBC). DOX in anthracycline-based chemotherapy regimens have higher response rates. Nano-drug delivery systems possess unique targeting and ability of co-load, deliver and release chemotherapeutic drugs, active gene fragments and immune enhancing factors to effectively inhibit or kill tumor cells. Therefore, advances in nano-drug delivery systems for DOX therapy have attracted a considerable amount of attention from researchers. In this article, we have reviewed the progress of nano-drug delivery systems (e.g., Nanoparticles, Liposomes, Micelles, Nanogels, Dendrimers, Exosomes, etc.) applied to DOX in the treatment of TNBC. We also summarize the current progress of clinical trials of DOX combined with immune checkpoint inhibitors (ICIS) for the treatment of TNBC. The merits, demerits and future development of nanomedicine delivery systems in the treatment of TNBC are also envisioned, with the aim of providing a new class of safe and efficient thoughts for the treatment of TNBC.

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“…The pattern observed from the 𝛿-alumina phase is barely visible anymore, which also indicates a full coating. [39,40]…”

Section: Copper-coated Microparticlesmentioning

confidence: 99%

Sugar‐Based Electroless Copper Deposition on Pectin‐Coated Alumina Microparticles

Mielewczyk,

Liebscher,

Grothe

et al. 2023

Adv Materials Inter

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A novel approach for fabricating copper‐coated alumina microparticles utilizing a pectin‐based coating subsequently followed by electroless deposition is reported. The biopolymer pectin is modified with phosphate groups covalently binding to the particle surface, while the polymer itself promotes the formation of metal centers on the surface due to the high affinity to metal cations. The sugar‐based (galactose, xylose, and glucose) electroless plating process in combination with an organic‐based treatment ensures a homogeneous metal coating method. As a benefit, precious metal activation of alumina particles and hazardous reducing agents typically employed are not required, creating a low‐cost and sustainable process. Metal plated micro particles show a uniform and homogeneous coating rendering them as ideal additives for application in metal matrix composites. These ceramic metal composites can be used in a wide range of applications where high‐strength metal components are needed.

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Click functionalized biocompatible gadolinium oxide core-shell nanocarriers for imaging of breast cancer cells

Abstract: Site-specific delivery using functionalized nanocarriers is in high demand in imaging applications of modern clinical research.

Cited by 5 publications

References 58 publications

Validation of Dual-Action Chemo-Radio-Labeled Nanocarriers with High Efficacy against Triple-Negative Breast Cancer

Validation of Dual-Action Chemo-Radio-Labeled Nanocarriers with High Efficacy against Triple-Negative Breast Cancer

Advances in Doxorubicin-based nano-drug delivery system in triple negative breast cancer

Sugar‐Based Electroless Copper Deposition on Pectin‐Coated Alumina Microparticles

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