Click reactions: Recent trends in preparation of new sorbents and stationary phases for extraction and chromatographic applications

Ghamat, Sima Najafi; Talebpour, Zahra; Mehdi, Ahmad

doi:10.1016/j.trac.2019.06.029

Cited by 32 publications

(7 citation statements)

References 185 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To achieve the excellent labeling efficiency of CuAAC, it is essential to ensure complete labeling of the target analyte. According to the reported conditions of CuAAC reaction, the labeling process was performed under catalysis from Cu +1 , which was generated via the in situ reduction of CuSO 4 by SA. , The sample extracts spiked with a mixture of steroid hormones were used in the following experiments with three replicates. Also, several reaction conditions including concentration of labeling reagent, CuSO 4 concentration, SA concentration, reaction temperature, and reaction time were optimized in detail.…”

Section: Resultsmentioning

confidence: 99%

Click Isotope Mass Probe for Highly Selective Determination of Trace Steroid Hormones in Food Samples

Liu

Zhang

et al. 2022

J. Agric. Food Chem.

View full text Add to dashboard Cite

Matrix effects are a great challenge for the quantitative analysis of complex food samples by liquid chromatography-tandem mass spectrometry analysis (LC-MS/MS). Stable isotope labeling (SIL) has been widely used as an effective strategy to eliminate matrix effects. Herein, a copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) click-reaction-based SIL method was proposed for a highly sensitive and selective determination of six synthetic steroid hormones in three different food samples (milk, yogurt, and eggs) by high-performance liquid chromatography (HPLC)-MS/MS. A pair of novel SIL agents, N-(2-azidyl ethyl) aniline (d 0-AEA) and d 5-N-(2-azidyl ethyl) aniline (d 5-AEA) were synthesized to label steroid hormones in the samples and standard solution, respectively. The reaction accomplishes in 30 min at 60 °C. The heavy labeled standards were used as internal standards (ISs), which experience the identical ionization processes with light labeled samples to minimize matrix effects. After derivatization, the ionization efficiencies of steroid hormones were greatly improved by 2–54-folds, and the matrix effects ranged from 88.6 to 99.8%. The established method achieved satisfactory detection limits (0.1–2.5 μg L–1) and high recoveries (85–102%). These results demonstrated that the proposed method holds unique advantages for trace steroid hormones analysis in foodstuffs.

show abstract

Section: Resultsmentioning

confidence: 99%

Click Isotope Mass Probe for Highly Selective Determination of Trace Steroid Hormones in Food Samples

Liu

Zhang

et al. 2022

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…In the separation field, click chemistry was applied for the preparation of new CSPs being involved in the linkage of the chiral selector onto the chromatographic support and in the synthesis of new selectors [ 81 ]. During the immobilization of the chiral selector, it is possible to control the reaction conditions to prevent side reactions with non-desirable functional groups [ 79 ].…”

Section: Immobilization Methodsmentioning

confidence: 99%

Strategies for Preparation of Chiral Stationary Phases: Progress on Coating and Immobilization Methods

et al. 2021

View full text Add to dashboard Cite

Enantioselective chromatography is one of the most used techniques for the separation and purification of enantiomers. The most important issue for a specific successful enantioseparation is the selection of the suitable chiral stationary phase (CSP). Different synthetic approaches have been applied for the preparation of CSPs, which embrace coating and immobilization methods. In addition to the classical and broadly applied coating and immobilization procedures, innovating strategies have been introduced recently. In this review, an overview of different methods for the preparation of coated and immobilized CSPs is described. Updated examples of CSPs associated with the various strategies are presented. Considering that after the preparation of a CSP its characterization is fundamental, the methods used for the characterization of all the described CSPs are emphasized.

show abstract

“…ПРИМЕНЕНИЕ ТИОЛ-ЕН "КЛИК" ХИМИИ Тиол-ен "клик" химия имеет обширную область применения, включая, но не ограничиваясь, получением биосовместимых сетчатых материалов [45], синтезом блок сополимеров [44], созданием деградируемых материалов [46], синтезом дендримеров [47], созданием новых гомогенных [48] и гибридных сетевых структур [49], функционализированных микросфер [50] и наночастиц [51], хроматографией [52], нанопечатью и литографией [53], жидкие кристаллы [54], оптические [55] и голографические материалы [56], гликополимерный синтезом [38], иммобилизацией белков [57], стабилизацией/функционализацией капсул и многослойных систем [58].…”

Section: рисунок 3 схема радикального механизма тиол-ен реакции [19]unclassified

Thiol-Ene “Click Reactions” as a Promising Approach to Polymer Materials

2021

View full text Add to dashboard Cite

show abstract

Click reactions: Recent trends in preparation of new sorbents and stationary phases for extraction and chromatographic applications

Cited by 32 publications

References 185 publications

Click Isotope Mass Probe for Highly Selective Determination of Trace Steroid Hormones in Food Samples

Click Isotope Mass Probe for Highly Selective Determination of Trace Steroid Hormones in Food Samples

Strategies for Preparation of Chiral Stationary Phases: Progress on Coating and Immobilization Methods

Thiol-Ene “Click Reactions” as a Promising Approach to Polymer Materials

Contact Info

Product

Resources

About