Climate change poses significant challenges to global health, with far-reaching implications for human health and well-being. This comprehensive review synthesizes evidence from diverse disciplines to elucidate the complex relationship between climate change and health. Key areas of focus include the direct impacts of extreme weather events, alterations in infectious disease transmission, air quality changes, food security issues, and mental health effects. Vulnerable populations, including low-income communities and indigenous peoples, are disproportionately affected, emphasizing the need for targeted interventions and equitable adaptation strategies. Methodologically, a search of peer-reviewed literature was conducted, covering studies published up to 2024. Both quantitative and qualitative studies were included, and thematic analysis was employed to identify patterns and trends. The review highlights gaps in current policy frameworks and international cooperation efforts, calling for enhanced collaboration and knowledge sharing to address the multifaceted challenges posed by climate change on health. Furthermore, proactive adaptation measures, robust public health infrastructure, and inclusive strategies are essential to mitigate adverse health impacts and foster resilience. By prioritizing collective action and interdisciplinary collaboration, we can work towards a healthier and more resilient future in the face of climate change.