This study investigates how life expectancy is influenced by CO2 emissions, health spending, GDP, water usage, agricultural output, and renewable and non-renewable energy consumption within the Aral Sea basin, which is an environmentally catastrophic zone in the world. This research utilized data from the years 2002 to 2020 and employed various econometric approaches, including FMOLS, DOLS, and Driscoll–Kraay. The outcomes of the study reveal that health spending, GDP, water productivity, agriculture output, energy consumption, and human capital have a positive impact on life expectancy, but CO2 emissions have a negative impact on life expectancy. The most important policy takeaway from this study is the need to develop and implement comprehensive policies that take into account health spending, GDP, water, agricultural output, energy consumption, and education level in order to ensure life longevity.