Clinical Analysis of Factors Affecting Hospital Mortality After Liver Transplant in Patients With High Model for End-Stage Liver Disease Score

Choi, Ho Joong; Na, Gun Hyung; Seo, Chang Ho; Park, Sung Eun; Ahn, Jae-Geun; Hong, Tae Ho; You, Young Kyoung

doi:10.1016/j.transproceed.2021.10.018

Cited by 1 publication

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“…Invasive bacterial infections are a leading cause of morbidity and mortality after liver transplant (LT) [ 1 , 2 ], with approximately two third of early deaths due to sepsis [ 3 , 4 ]. Bacterial infections are the most common cause of complications within the first month after LT [ 2 ] and are often due to nosocomial organisms [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and Prevention of Early Infections by Multi-Drug-Resistant Organisms in Adults Undergoing Liver Transplant: A Narrative Review

et al. 2023

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Invasive bacterial infections are a leading cause of morbidity and mortality after liver transplant (LT), especially during the first months after LT, and infections due to multi-drug-resistant organisms (MDRO) are increasing in this setting. Most of the infections in patients in intensive care unit arise from the endogenous microflora and, for this reason, pre-LT MDRO rectal colonization is a risk factor for developing MDRO infections in the post-LT. Moreover, the transplanted liver may carry an increased risk of MDRO infections due to organ transportation and preservation, to donor intensive care unit stay and previous antibiotic exposure. To date, little evidence is available about how MDRO pre-LT colonization in donors and recipients should address LT preventive and antibiotic prophylactic strategies, in order to reduce MDRO infections in the post-LT period. The present review provided an extensive overview of the recent literature on these topics, with the aim to offer a comprehensive insight about the epidemiology of MDRO colonization and infections in adult LT recipients, donor-derived MDRO infections, possible surveillance, and prophylactic strategies to reduce post-LT MDRO infections.

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