Clinical and bacteriological outcome of different doses and duration of pivmecillinam compared with placebo therapy of uncomplicated lower urinary tract infection in women: The LUTIW project

Ferry, Sven; Holm, Stig E.; Stenlund, Hans; Lundholm, Rolf; Monsen, Tor

doi:10.1080/02813430601183074

Cited by 142 publications

(169 citation statements)

References 29 publications

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“…A subset of 54 strains was analyzed with PFGE, and 94% of these isolates showed PFGE patterns that were identical to that of the primary infecting strain. Those and our results support previous findings showing that the clinical course, short-term persistence rate, and spontaneous cure rate for S. saprophyticus UTI resembles that of E. coli infections (3,6,7).…”

Section: Discussionsupporting

confidence: 83%

“…The Ethics Committee of Umeå University, Sweden, approved the trial, and informed written consent was obtained from each included patient. Details concerning the design and the general outcome of the trial have previously been described (4,6,7). These strains were compared with an additional 50 clinical isolates of S. saprophyticus obtained from five different locations in northern Europe.…”

Section: Methodsmentioning

confidence: 99%

“…Urine samples in the original trial were analyzed within 24 h at the Department of Clinical Bacteriology, University Hospital of Umeå. Significant or nonsignificant uropathogens were quantified (CFU/ml) as previously described (6,7). For the present study, all coagulase-negative staphylococcal isolates were reanalyzed according to a previously described species identification system (15).…”

Section: Methodsmentioning

confidence: 99%

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Molecular Epidemiology of Staphylococcus saprophyticus Isolated from Women with Uncomplicated Community-Acquired Urinary Tract Infection

et al. 2007

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Staphylococcus saprophyticus is a common cause of urinary tract infections (UTIs) in women. Little is known about the molecular epidemiology of S. saprophyticus UTIs. In the current study, we compared 76 isolates of S. saprophyticus prospectively isolated from women with uncomplicated UTI participating in a randomized placebo-controlled treatment trial performed in northern Sweden from 1995 to 1997 with 50 strains obtained in 2006 from five different locations in northern Europe with pulsed-field gel electrophoresis (PFGE). The aim was to elucidate the molecular epidemiology of this uropathogenic species and to investigate whether specific clones are associated with UTI in women. A total of 47 different PFGE profiles were detected among the 126 analyzed isolates. Ten clusters consisting of 5 to 12 isolates each showing PFGE DNA similarity of >85% were identified. Several clusters of genetically highly related isolates were detected in the original trial as well as among isolates obtained during 2006 from different locations. In the original trial, clonal persistence was found among 16 of 21 (76%) patients examined in the placebo group at follow-up 8 to 10 days after inclusion, indicating a low spontaneous short-time bacteriological cure rate. We conclude that multiple clones of S. saprophyticus were causing lower UTIs in women. The result suggests that some human-pathogenic clones of S. saprophyticus are spread over large geographical distances and that such clones may persist over long periods of time.

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Section: Discussionsupporting

confidence: 83%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Molecular Epidemiology of Staphylococcus saprophyticus Isolated from Women with Uncomplicated Community-Acquired Urinary Tract Infection

et al. 2007

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“…Conversely, our results confirm the findings of Ferry et al, 10 who also found no correlation between symptoms and symptom scores at inclusion, on the one hand, and bacteriuria, bacterial counts, or species on the other. Likewise Baerheim et al 4 could not show any differences in frequency or in the pattern of the symptoms between patients with or without bacteriuria.…”

Section: Bacterial Culture and Clinical Symptomssupporting

confidence: 82%

Cystitis: Symptomatology in Women with Suspected Uncomplicated Urinary Tract Infection

Heytens

Sutter

Backer

et al. 2011

Journal of Women's Health

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Background: Although cystitis in women is very common in general practice, its evolution in symptoms has not been clearly studied. Qualitative research has pointed to other than the classic symptomatology. Methods: This was a prospective observational study of the symptomatology at presentation and the evolution of the symptoms in treated women with suspected uncomplicated urinary tract infection (UTI). Women consulting their general practitioner (GP) for dysuria, urgency, or frequency produced a urine sample (for bacteriologic processing) and kept a diary until the end of the symptoms. Exclusion criteria included complaints > 1 week, fever, vaginal discharge, and known pathology. Results: Of the 300 asked to participate, 148 (49%) returned the diary. Although none of the patients developed acute pyelonephritis, a substantial number of the women had such complaints as feeling feverish (33% in culture-positive group, 38% in culture-negative group), back pains (44% vs. 56%), and feeling weak and tired (71% vs. 65%). Differences between the culture-positive and culture-negative groups were not statistically significant except for the duration of symptoms, which was shorter in the culture-positive group (4 vs. 6 days). More severe symptoms at inclusion were correlated with a longer duration of these symptoms. Conclusions: The spectrum of complaints in women with suspected uncomplicated UTI is broad and comprises a number of symptoms usually associated with an upper UTI. The occurrence of these symptoms should not automatically prompt GPs to prescribe broad-spectrum antibiotics. Moreover, the duration of symptoms exceeding the recommended duration of antibiotic therapy does not indicate therapy failure and, thus, the need for changing antibiotic therapy.

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“…Ввиду опасности полной потери чувствительности бактерий к антибиотикам разрабатываются мероприятия по сдерживанию ре-зистентности возбудителей, направленные на сниже-ние антибиотического прессинга [5]. Целесообразность ограничительных мер показа-на на примерах неосложненных инфекций мочевой системы у взрослых, когда в параллельных группах, получавших антибиотики или плацебо, наблюдались сравнимые результаты лечения [6,7]. При подобной патологии у детей длительность активных проявле-ний заболевания оказалась одинаковой как в случае раннего использования антибиотиков, так и при от-сроченном их назначении [8].…”

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Non-antibacterial alternative measures for urinary tract infection in children. Part 1. Suppression of the microbial initiation of the inflammation

Кириллов¹,

Богданова²,

Морозов³

2018

Ross. vestn. perinatol. pediatr.

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Clinical and bacteriological outcome of different doses and duration of pivmecillinam compared with placebo therapy of uncomplicated lower urinary tract infection in women: The LUTIW project

Cited by 142 publications

References 29 publications

Molecular Epidemiology of Staphylococcus saprophyticus Isolated from Women with Uncomplicated Community-Acquired Urinary Tract Infection

Molecular Epidemiology of Staphylococcus saprophyticus Isolated from Women with Uncomplicated Community-Acquired Urinary Tract Infection

Cystitis: Symptomatology in Women with Suspected Uncomplicated Urinary Tract Infection

Non-antibacterial alternative measures for urinary tract infection in children. Part 1. Suppression of the microbial initiation of the inflammation

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