Clinical and cognitive factors affecting psychosocial functioning in remitted patients with bipolar disorder

Konstantakopoulos, George; Ioannidi, N.; Typaldou, Maria; Sakkas, D.; Oulis, Panagiotis

doi:10.22365/jpsych.2016.273.182

Cited by 20 publications

(14 citation statements)

References 33 publications

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“…Of the 20 cross‐sectional studies included in this review, 9 (all published between 2002 and 2016) used the GAF as the sole functioning scale . Four of these studies compared overall functioning between patients with euthymic BP‐I or BP‐II vs healthy controls, and four compared functioning between BP‐I, BP‐II, and/or healthy controls or between patients with BP‐I and BP‐II with different mood states (ie, depression, major depression, mania, hypomania, and euthymia) or functioning (ie, low vs high) . The remaining study used the GAF to compare functioning in patients with euthymic BD and patients with schizophrenia.…”

Section: Resultsmentioning

confidence: 99%

“…The remaining study used the GAF to compare functioning in patients with euthymic BD and patients with schizophrenia. Eight of these nine studies that used only the GAF to measure psychosocial functioning evaluated the association between psychosocial functioning and ≥1 cognitive domain (eg, attention, learning and memory, executive function, language). Five of these studies also assessed correlations between the GAF and demographic and/or clinical variables, such as duration of illness, number of hospitalizations, number and type of episodes, symptom type and severity, and medications.…”

Section: Resultsmentioning

confidence: 99%

“…Eight of these nine studies that used only the GAF to measure psychosocial functioning evaluated the association between psychosocial functioning and ≥1 cognitive domain (eg, attention, learning and memory, executive function, language). Five of these studies also assessed correlations between the GAF and demographic and/or clinical variables, such as duration of illness, number of hospitalizations, number and type of episodes, symptom type and severity, and medications. One study also evaluated the relationship between psychosocial functioning and theory of mind, the ability to perceive other people's mental states .…”

Section: Resultsmentioning

confidence: 99%

“…Five of these studies also assessed correlations between the GAF and demographic and/or clinical variables, such as duration of illness, number of hospitalizations, number and type of episodes, symptom type and severity, and medications. One study also evaluated the relationship between psychosocial functioning and theory of mind, the ability to perceive other people's mental states . The ninth study used the GAF to assess functioning and symptoms in patients with BD.…”

Section: Resultsmentioning

confidence: 99%

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Functional outcome assessment in bipolar disorder: A systematic literature review

et al. 2019

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Objectives Functional impairment is an important driver of disability in patients with bipolar disorder (BD) and can persist even when symptomatic remission has been achieved. The objectives of this systematic literature review were to identify studies that assessed functioning in patients with BD and describe the functional scales used and their implementation. Methods A systematic literature review of English‐language articles published between 2000 and 2017 reporting peer‐reviewed, original research related to functional assessment in patients with BD was conducted. Results A total of 40 articles met inclusion criteria. Twenty‐four different functional scales were identified, including 13 clinician‐rated scales, 7 self‐reported scales, and 4 indices based on residential and vocational data. The Global Assessment of Functioning (GAF) and the Functional Assessment Short Test (FAST) were the most commonly used global and domain‐specific scales, respectively. All other scales were used in ≤2 studies. Most studies used ≥1 domain‐specific scale. The most common applications of functional scales in these studies were evaluations of the relationships between global or domain‐specific psychosocial functioning and cognitive functioning (eg, executive function, attention, language, learning, memory) or clinical variables (eg, symptoms, duration of illness, number of hospitalizations, number of episodes). Conclusions The results of this review show growing interest in the assessment of functioning in patients with BD, with an emphasis on specific domains such as work/educational, social, family, and cognitive functioning and high utilization of the GAF and FAST scales in published literature.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Functional outcome assessment in bipolar disorder: A systematic literature review

et al. 2019

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“…Future studies should consider the combination of subjective and objective measures to capture a more comprehensive picture of the patient outcomes . Moreover, the study of other characteristics that may be influencing functional outcomes such as premorbid social and academic adjustment , contextual factors and personality traits , social cognition and proxies of cognitive reserve would be of interest.…”

Section: Discussionmentioning

confidence: 99%

Heterogeneity of functional outcomes in patients with bipolar disorder: a cluster‐analytic approach

Solé

Bonnín

Jiménez

et al. 2018

Acta Psychiatr Scand

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The efficacy of vitamin B6 as an adjunctive therapy to lithium in improving the symptoms of acute mania in patients with bipolar disorder, type 1; a double‐blind, randomized, placebo‐controlled, clinical trial

et al. 2021

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Objective: Vitamin B6 has been linked to a variety of probable roles, including antiinflammatory, homocysteine-lowering, serotonin-regulating, and dopamine-lowering.In this study, we investigated the possible effect of vitamin B6 on bipolar disorder in manic episode with psychotic feature in a placebo-controlled double-blind clinical trial in a psychiatric hospital. Methods:This study was performed on 50 patients who were equally divided into two groups (each group included 25 patients) using 80 mg of vitamin B6 daily or placebo.At the beginning and end of the study, they were evaluated for lab tests, inflammatory biomarkers and level of blood homocysteine. Also, at the baseline and in weeks 2, 4, and 8, they were evaluated based on the anthropometric measurements, score obtained from the Young Mania Questionnaire, Mini-Mental State Examination (MMSE), and the Pittsburgh Sleep Questionnaire.Results: Accordingly, based on Yang Mania scoring scale, no significant difference was observed between the two groups receiving vitamin B6 and placebo (22.68 ± 5.39 vs. 21.80 ± 5.39 [p-value = .51]). Based on MMSE, significant improvement in cognitive status was obtained in group placebo compared to vitamin B6 group (25.24 ± 1.96 vs. 24.40 ± 3.25, respectively [p-value = .01]). At the Pittsburg scale (total, there was no statistically significant difference between the two groups receiving vitamin B6 and placebo (1.04 ± 0.20 vs. 0.48 ± 0.50 [p-value = .23]). Additionally, no significant difference was observed between the two groups regarding the anthropometric status.Conclusions: According to this study, the daily dose of 80 mg of vitamin B6 for 8 weeks in patients with bipolar disorder in the manic episode with psychotic feature treated daily with lithium, was not associated with a significant improvement in mood status compared to the control-placebo group. It is recommended to perform similar studies in a multi-center manner with a larger sample size and longer duration.

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Clinical and cognitive factors affecting psychosocial functioning in remitted patients with bipolar disorder

Cited by 20 publications

References 33 publications

Functional outcome assessment in bipolar disorder: A systematic literature review

Functional outcome assessment in bipolar disorder: A systematic literature review

Heterogeneity of functional outcomes in patients with bipolar disorder: a cluster‐analytic approach

The efficacy of vitamin B6 as an adjunctive therapy to lithium in improving the symptoms of acute mania in patients with bipolar disorder, type 1; a double‐blind, randomized, placebo‐controlled, clinical trial

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