Clinical and Electroencephalographic Study on Convulsive Disorders in Infancy and Early Childhood

Kajitini, T; Fujiwara, Junko; Kobuchi, S; Ueoka, Kiyotaka

doi:10.1111/j.1440-1819.1976.tb02276.x

Cited by 1 publication

(4 citation statements)

References 6 publications

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“…The systematic review included 26 studies (Table S1) between 1978 and 2022 5,6,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40 . All reported ≥1 cases within inclusion criteria and data related to our primary mortality outcome (11), or secondary outcomes of neurodevelopment (11) or neuropathology (13).…”

Section: Resultsmentioning

confidence: 99%

“…Postictal sleep EEG recordings on 17 cases of complex febrile seizures were also considered normal 28 . Among 154 cases with simple febrile seizures only, 3% (5/154) had abnormal EEG findings with small focal spikes ( n = 3) and bilateral small spikes ( n = 2) 32 . Among 32 cases with recurrent febrile seizures within a 24 h timeframe and evaluated with EEG within 3 months of event, 12.5% (4/32) had abnormal EEG findings related to diffuse onset tonic–clonic seizure, diffuse slowing, occipital rhythmic delta activity, or bifrontal and left central spikes 21 …”

Section: Resultsmentioning

confidence: 99%

“…The systematic review included 26 studies (Table S1) between 1978 and 2022 . 5,6,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40 All reported ≥1 cases within inclusion criteria and data related to our primary mortality outcome (11), or secondary outcomes of neurodevelopment (11) or neuropathology (13). Two studies (Krous et al 5 and Kinney et al 39 ) reported mortality data from the same case registry with undefined case redundancy that could not be clarified after contact with the author.…”

Section: Included Studiesmentioning

confidence: 99%

“…28 Among 154 cases with simple febrile seizures only, 3% (5/154) had abnormal EEG findings with small focal spikes (n = 3) and bilateral small spikes (n = 2). 32 Among 32 cases with recurrent febrile seizures within a 24 h timeframe and evaluated with EEG within 3 months of event, 12.5% (4/32) had abnormal EEG findings related to diffuse onset tonic-clonic seizure, diffuse slowing, occipital rhythmic delta activity, or bifrontal and left central spikes. 21 Four studies reported postmortem histopathological neuropathology across two case series, one case report, and one case control study of 29 unique sudden death cases (26 simple and 3 complex febrile seizures) vs 87 controls.…”

Section: Neuropathologymentioning

confidence: 99%

See 3 more Smart Citations

Are brief febrile seizures benign? A systematic review and narrative synthesis

Crandall

Delavale

Plovnick³

et al. 2023

Epilepsia

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Febrile seizures affect 2%–5% of U.S. children and are considered benign although associated with an increased risk of epilepsy and, rarely, with sudden unexplained death. We compared rates of mortality, neurodevelopmental disorders, and neuropathology in young children with simple and complex febrile seizures to healthy controls. We systematically reviewed studies of 3‐ to 72‐month‐old children with simple or complex febrile seizures ≤30 min. We searched studies with outcome measures on mortality, neurodevelopment, or neuropathology through July 18, 2022. Bias risk was assessed per study design. Each outcome measure was stratified by study design. PROSPERO registration is CRD42022361645. Twenty‐six studies met criteria reporting mortality (11), neurodevelopment (11), and neuropathology (13), including 2665 children with febrile seizures and 1206 seizure‐free controls. Study designs varied: 15 cohort, 2 cross‐sectional, 3 case–control, 5 series, and 1 case report. Mortality outcomes showed stark contrasts. Six cohort studies following children after febrile seizure (n = 1348) reported no deaths, whereas four child death series and 1 case report identified 24.1% (108/449) deaths associated with simple (n = 104) and complex (n = 3) febrile seizures ≤30 min. Minor hippocampal histopathological anomalies were common in sudden deaths with or without febrile seizure history. Most electroencephalography (EEG) studies were normal. Neuroimaging studies suggested increased right hippocampal volumes. When present, neurodevelopmental problems usually preexisted febrile‐seizure onset. Risk bias was medium or high in 95% (18/19) of cohort and case–control studies vs medium to low across remaining study designs. Research on outcomes after simple or brief complex febrile seizures is limited. Cohort studies suffered from inadequate sample size, bias risk, and limited follow‐up durations to make valid conclusions on mortality, neurodevelopment, and neuropathology. Sudden death registries, focused on a very small percentage of all cases, strongly suggest that simple febrile seizures are associated with increased mortality. Although most children with febrile seizures have favorable outcomes, longer‐term prospective studies are needed.

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Section: Resultsmentioning

confidence: 99%