Clinical and hormonal evaluation in facial pigmentary demarcation lines: A pilot study

Voigt‐Futcher pigmentary demarcation lines

“…The skin biopsy specimen in PDLs (type B) shows a slight lymphocyte infiltration around vessels in the upper dermis with mild basal layer hyperpigmentation . In another study, basal and suprabasal pigmentation with mild pigment incontinence in papillary dermis was evident histologically; there may be only increased melanization . There are clinically inconspicuous melanocytes in areas innervated by peripheral nerves.…”

“…Hormones, such as melanocyte‐stimulating hormone secreted during pregnancy, may also trigger the hyperpigmentation of peripheral nerve areas . In case of facial PDLs, in about 83% of female patients there have been found abnormalities in gonadotropic hormones, as well as in estrogen and progesterone levels, with low FSH and low estrogen being the commonest …”

Nevus depigmentosus: review of a mark of distinction

“…37 Hormonal changes during pregnancy are thought to be contributors to PDL formation. 38 Spontaneous regression of PDLs after birth in mothers has also been seen. 39 Treatment Treatment is mainly for aesthetics.…”

“…PDLs are diagnosed clinically . Biopsy of PDLs in one study revealed pigment incontinence in papillary dermis with pigmentation in the basal layer; another study showed no histopathological findings except for increased melanization in some patients . Hormonal changes during pregnancy are thought to be contributors to PDL formation .…”

“…Pigmentary demarcation lines 37,38 No histological findings to pigment incontinence in papillary dermis with pigmentation in basal layer possible.…”