Clinical and Immulogical Aspects in Patients With Chronic Bacterial Prostatitis Undergoing Immunomodulatory Therapy

Efremov, E.A.; Камалов, А А; Dorofeev, S D; Mel'nik, Ja I; Ochobotov, D.A.; Bedretdinova, Dina

doi:10.1016/s1569-9056(08)60346-2

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“…CBP is a chronic inflammatory process linked with changes in the immune system. [ 9 ] IL-8 is a pro-inflammatory cytokine and was synthesized and secreted by a variety of somatic cells and could be detected after a few hours of infection. Some researches showed that IL-8 was detected in a high proportion of men with CP/CPPS but was undetectable in normal people, confirming the role of this chemokine in the pathogenesis of CP.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Chinese medicine Qian-Yu for chronic bacterial prostatitis in rats

Yuan

Zhang

et al. 2011

Indian J Pharmacol

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Objectives:Qian-Yu (QY), a Chinese medicine formula, has anti-inflammatory and broad spectrum anti-bacterial activity. This study is undertaken to evaluate the anti-inflammatory effects of Qian-Yu (QY) in chronic bacterial prostatitis (CBP).Materials and Methods:The potential of QY in the treatment of CBP was evaluated using a CBP animal model by examining the anti-inflammatory activity. Its consequences were analyzed by immunological and histopathological methods. Experimental chronic bacterial prostatitis was induced by instillation of bacterial suspension of Escherichia coli 7.5 × 105 CFU/ml into the prostatic urethra. Animals were followed up for four weeks and then treated with either 7 mg/kg QY or 7 mg/kg positive control agent-Qianlietai (QLT) or 1 ml of phosphate-buffered saline (PBS) for the controls. Ten rats in each group were sacrificed at the end of four weeks. The inhibition of inflammation and its consequences were analyzed histologically. Prostatic IL-8, SIgA and zinc concentrations were measured by ELISA, RIA and ICP-AES, respectively. The data was expressed as mean ± S.D. Least-significant difference (LSD) of one-way ANOVA (SPSS 12.0) was used to determine the differences of scores.Results:The histopathology showed resolving prostatitis in QY-and QLT-treated groups and the immunology showed reduction of IL-8 and increment of SIgA contents in prostatic tissues as compared to the control groups. The prostatic zinc levels were higher in the QY-and QLT-treated groups than those in the controls. These results suggested that QY is effective in CBP treatment.

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Section: Discussionmentioning

confidence: 99%