1985
DOI: 10.1016/s0190-9622(85)70013-8
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Clinical and immunologic response to Isoprinosine in alopecia areata and alopecia universalis: Association with autoantibodies

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Cited by 30 publications
(7 citation statements)
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“…Positive immunomodulating effects of IP have been demonstrated in several studies on patients with autoimmune diseases, such as alopecia, rheumatoid arthritis or aphthous stomatitis, but further investigation is warranted to determine the efficacy of IP in the treatment of specific autoimmune diseases. In therapeutic studies, positive clinical effects of IP, at doses of 25–50 mg/kg daily (1.5–3 g), have been reported in the majority of treated patients with aphthous stomatitis [41] and alopecia [39, 40, 90].…”
Section: Therapeutic Trialsmentioning
confidence: 99%
“…Positive immunomodulating effects of IP have been demonstrated in several studies on patients with autoimmune diseases, such as alopecia, rheumatoid arthritis or aphthous stomatitis, but further investigation is warranted to determine the efficacy of IP in the treatment of specific autoimmune diseases. In therapeutic studies, positive clinical effects of IP, at doses of 25–50 mg/kg daily (1.5–3 g), have been reported in the majority of treated patients with aphthous stomatitis [41] and alopecia [39, 40, 90].…”
Section: Therapeutic Trialsmentioning
confidence: 99%
“…These modalities include aromatherapy,87 a combination of topical garlic gel and betamethasone valerate cream,88 topical azelic acid,89 oral zinc supplementation,90–92 topical onion juice,93 a simvastatin-ezetimibe combination,94,95 inosiplex,9698 and intralesional injections of candida antigen 99. These treatment modalities need to be confirmed in large-scale, double-blind, placebo-controlled trials.…”
Section: Other Therapiesmentioning
confidence: 99%
“…Isoprinosine ® ( level of evidence 2– ) Isoprinosine ® (Newport Pharmaceuticals, Swords, Ireland) is an old drug that has immunostimulatory and antiviral properties. Early uncontrolled studies of its use in alopecia areata reported mixed positive 84 and negative results 85 . A more recent RCT in 32 patients with recalcitrant alopecia areata reported complete remission at 12 weeks in 50% of patients taking Isoprinosine compared with none in the placebo control group 86 …”
mentioning
confidence: 99%