Clinical and laboratory findings in mad honey poisoning: A single center experience

Abstract

Mad honey poisoning should be considered in previously healthy patients with unexplained symptoms of bradycardia, hypotension, and cardiac dysrhythmias. Therefore, diet history should carefully be obtained from the patients admitted with bradycardia and hypotension, and mad honey intoxication should also be considered in the differential diagnosis, as well as primary cardiac, neurologic, and metabolic disorders. Mad honey poisoning may be presented with life-threatening symptoms without any hematological and biochemical disorder.

Cardiovascular, psychiatric, and neurological phenomena seen in mad honey disease: A clinical case report

“…Though various animal studies have been conducted to elucidate the mechanism by which grayanotoxins act, the dose-response relationship in both animal and human systems has not been well established. 6,10 Lower doses of honey could have potentially therapeutic shortterm antiarrhythmic and long-term cardiovascular benefits. As the old adage goes, "One man's poison is another man's cure".…”

“…As a voltage‐gated sodium channel molecular toxin targeted at binding the group II receptor site, intoxication of the said substance usually manifests with parasympathetic overactivity characterized by dizziness, hypotension, and cardiac rhythm disorders (eg, sinus bradycardia and atrioventricular blockade) . More uncommonly, there have been reported cases of syncope, myocardial infarction, asystole, diplopia, convulsions, and hepatotoxicity caused by mad honey poisoning …”

“…myocardial infarction, asystole, diplopia, convulsions, and hepatotoxicity caused by mad honey poisoning. [10][11][12][13] In this report, we present the case of a 52-year-old woman from the indigenous Gurung community of Nepal who presented to the hospital with a chief complaint of shortness of breath and a burning sensation in her chest after ingestion of red honey. She subsequently developed visual hallucinations, a clumsy broad-based gait, and numbness of the peripheries.…”

The dose-dependent cardiovascular effects of intravenous grayanotoxin-III in rats

“…yolla verdiği çalışma bulgularıyla da uyumludur. Sonuç olarak, grayanotoksin-III içeren deli bal zehirlenme olgularından elde edilen klinik bulgularda da bu durum gözlenmektedir (31)(32)(33)(34) . Ancak etkinin doza bağımlı arttığının gösterilmesi bulgularımızı değerli kılmaktadır.…”

“…Zehirlenme olgularından elde edilen klinik intoksikasyon verilerine göre insanlarda gastrointestinal sistemden emilen toksin miktarı çoğunlukla minimal etkin doz ile letal doz arasında kalmaktadır. İntoksikasyon bulgularının 4-6 saat sürmesi de (31)(32)(33)(34) emilimin yavaş ve uzun süre devam ettiğini destekler niteliktedir. Bununla birlikte, türler arasında farklılık-lar olabileceği ve deli bal içerisinde bulunması olası diğer toksin ve maddelerin de toksisiteye katkı sağla-yabileceği unutulmamalıdır (35,36) .…”