Clinical and molecular comparison between short- and long-course preoperative radiotherapy for rectal cancer.

Inoue, Yasuhiro; Saigusa, Susumu; Hiro, J.; Toiyama, Y.; Tanaka, Kichinosuke; Mohri, Y.; Kusunoki, Masato

doi:10.1200/jco.2011.29.15_suppl.e14093

Cited by 2 publications

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“…All included studies provided OS information, however, 2 [ 32 – 33 ] studies did not provide HR information. Klenova A [ 33 ] reported that the 4-year OS were 72% and 70% in SCRT and LCRT groups, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Klenova A [ 33 ] reported that the 4-year OS were 72% and 70% in SCRT and LCRT groups, respectively. Inoue Y [ 32 ] showed that the 5-year OS rate were 83.3% (LCRT) versus 83.4% (SCRT). Meta-analysis of the available data pooled by fixed-effect model showed that the result of the heterogeneity test was p = 0.79/ I 2 = 0%, and no significant difference was observed in OS between SCRT and LCRT groups (HR = 0.92, 95% CI: 0.75–1.13, p = 0.44) ( Fig 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…10 out of 11 studies reported DFS. Inoue Y [ 32 ] provided that the 4-year DFS were 66% and 68% in SCRT and LCRT groups, respectively. However, no information for obtaining HR was provided.…”

Section: Resultsmentioning

confidence: 99%

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Preoperative short-course radiotherapy and long-course radiochemotherapy for locally advanced rectal cancer: Meta-analysis with trial sequential analysis of long-term survival data

Wang

Zheng

et al. 2018

PLoS ONE

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Background and purposeThe role of preoperative short-course radiotherapy (SCRT) in rectal cancer treatment, when compared to long-course radiochemotherapy (LCRT), is still controversial. Thus the meta-analysis with trial sequential analysis (TSA) was performed to evaluate the long-term survival of SCRT and LCRT as therapeutic regimens for locally advanced rectal cancer.Material and methodsPubMed, Embase, and the Cochrane Central Register of Controlled Trials were searched up to August 2017 for eligible studies. Hazard ratios (HRs) or odds ratios (ORs) of overall survival (OS), disease free survival (DFS) and local recurrence (LR) with the corresponding 95% confidence intervals (CIs) were calculated and TSA was applied.Results11 studies with 1984 patients were included. There was no significant difference in OS (HR = 0.92, 95% CI: 0.75–1.13, p = 0.44), DFS (HR = 0.94, 95% CI: 0.79–1.12, p = 0.50) and LR (OR = 0.73, 95% CI: 0.49–1.08, p = 0.11) between SCRT and LCRT groups. TSA suggested firm evidence for lacking on average a -10% relative risk reduction (RRR) in 4-year OS but no statistical significance in 4-year DFS.ConclusionsPreoperative SCRT is as effective as LCRT for locally advanced colorectal cancer in long-term survival. SCRT could be preferential while facing long waiting lists or lacking medical resource.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%