Clinical and Molecular Inflammatory Response in Sjögren Syndrome–Associated Dry Eye Patients Under Desiccating Stress

López-Miguel, Alberto; Tesón, Marisa; Martín-Montañéz, Vicente; Salamanca, Andrés Bordalí; Stern, Michael E.; González-García, María J.; Calonge, Margarita

doi:10.1016/j.ajo.2015.09.039

Cited by 62 publications

(50 citation statements)

References 44 publications

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“…We intended to go further in predicting the development of ocular cGVHD, and so we studied tear levels of known inflammatory mediators rather than clinical parameters in an attempt to find more objective risk factors of the disease, as we had done previously with other types of DED. 20,26,27 In the field of predictive, preventive, and personalized medicine, biomarkers have had a key role in the discovery of new therapeutic targets and point-of-care device design. 49 In fact, approaches based on molecular biomarkers have been clearly established clearly by an expert panel.…”

Section: Discussionmentioning

confidence: 99%

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Prehematopoietic Stem Cell Transplantation Tear Cytokines as Potential Susceptibility Biomarkers for Ocular Chronic Graft-Versus-Host Disease

Cocho

Fernández

Calonge

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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Section: Discussionmentioning

confidence: 99%

“…We analyzed the samples as reported previously 14,20,26,27 following the manufacturer's protocol. Data were stored and analyzed using the ''Bead View Software'' (Upstate, Millipore Upstate-Millipore, Dundee, UK).…”

Section: Analysis Of Tear Moleculesmentioning

confidence: 99%

Prehematopoietic Stem Cell Transplantation Tear Cytokines as Potential Susceptibility Biomarkers for Ocular Chronic Graft-Versus-Host Disease

Cocho

Fernández

Calonge

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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“…), and the sensory and motor nerves that connect them. 1,20,21 In our previous study, we found certain inflammatory mediators, such as IL-1b and intercellular adhesion molecule 1 (ICAM-1), were upregulated in the tear fluid and lacrimal gland in this animal model, whereas they were markedly suppressed in the fingolimod-treated groups. 17 Inflammatory mediators in tear fluid are likely from lacrimal gland and/or ocular tissues, such as the cornea and conjunctiva.…”

Section: Fingolimod Suppressed Inflammatory Mediators In Ocular Surfamentioning

confidence: 75%

Fingolimod Suppresses a Cascade of Core Vicious Cycle in Dry Eye NOD Mouse Model: Involvement of Sphingosine-1-Phosphate Receptors in Infiltrating Leukocytes

Xiao

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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“…It should be noted that conjunctival hyperaemia is the result of vascular vasodilation secondary to an increase in mediators of inflammation that are increased in certain phases of symptomatic dry eye (López‐Miguel et al. ). In this sense, hyperaemia can be considered as an indirect marker of inflammation of the ocular surface.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of treatment of hyposecretory dry eye with platelet‐rich plasma

Garcia-Conca

Abad-Collado²,

Hueso-Abancens

et al. 2018

Acta Ophthalmologica

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Objective: To evaluate and compare the symptomatology and clinical findings in hyposecretory dry eye of the treatment with platelet-rich plasma (PRP) and artificial tears of sodium hyaluronate (SH). Methods: Blind single-centre prospective comparative randomized study including 83 patients with hyposecretory dry eye and mean age of 64.0 years. Two groups were differentiated depending on the treatment applied: 44 patients treated with PRP (PRP group), and 39 patients treated with artificial tears of SH (SH group). Changes in Schimer test, tear osmolarity, corneal and conjunctival staining, tear film break-up time (TF-BUT), conjunctival hyperaemia, dry eye-related symptoms with the Ocular Surface Disease Index questionnaire, and caliciform cell density were evaluated during 30 days of treatment.Results: Significantly larger reduction in symptomatology (p < 0.001), visual improvement (p < 0.001), reduction in hyperaemia (p < 0.001), and corneal and conjunctival staining (p < 0.001), increment of Schirmer test outcome (p ≤ 0.005), and reduction of osmolarity were found in the PRP group in both eyes compared to SH group at 15 and 30 days of treatment. Likewise, a significantly higher increment of caliciform cell density (p < 0.001) was found in the PRP group. Strong and statistically significant correlations were found in the PRP group of the change achieved in visual acuity, hyperaemia, osmolarity, and conjunctival and corneal staining with the baseline values of these variables (p < 0.001). Conclusion: PRP treatment in hyposecretory dry eye induces a more significant positive effect over symptomatology and different dry eye signs than SH, especially in moderate and severe cases.

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Clinical and Molecular Inflammatory Response in Sjögren Syndrome–Associated Dry Eye Patients Under Desiccating Stress

Cited by 62 publications

References 44 publications

Prehematopoietic Stem Cell Transplantation Tear Cytokines as Potential Susceptibility Biomarkers for Ocular Chronic Graft-Versus-Host Disease

Prehematopoietic Stem Cell Transplantation Tear Cytokines as Potential Susceptibility Biomarkers for Ocular Chronic Graft-Versus-Host Disease

Fingolimod Suppresses a Cascade of Core Vicious Cycle in Dry Eye NOD Mouse Model: Involvement of Sphingosine-1-Phosphate Receptors in Infiltrating Leukocytes

Efficacy and safety of treatment of hyposecretory dry eye with platelet‐rich plasma

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