Clinical and morphological features of malignant hyperthermia: a rare case from practice

Abstract

One of the most serious complications of modern anesthesia is malignant hyperthermia, which is a pharmacogenetic disease, phenotypically manifested by skeletal muscle hypermetabolism and rhabdomyolysis during or after general anesthesia with the use of inhalation anesthetics. In Russia, the problem of malignant hyperthermia currently remains unresolved. We present a case of malignant hyperthermia in a 19-year-old girl who was operated on for nasal breathing disorders and received Sevoran anesthesia as support. The patient died 1 hour and 25 minutes later. after the end of the operation during withdrawal from anesthesia due to the development of a clinically confirmed syndrome of malignant hyperthermia. At the forensic autopsy, this diagnosis was confirmed. A description of the morphological changes in the skeletal muscles using both plain and elective histological stains is given.