Clinical and pathologic findings in 52 consecutively autopsied cases with multiple myeloma

Abstract

We studied clinical features and pathologic findings in 52 consecutively autopsied patients with multiple myeloma in our center between 1979 and 1998. Distant extraosseous involvement was found in 33 patients (63.5%). Thirty-one patients (59.6%) were proven to have infection at autopsy, among which pneumonia was most common site of infection. Amyloidosis was shown in 8 patients. Second malignancies were observed in 4 cases. The three major causes of death were hemorrhage, infection, and renal failure, which accounted for death in approximately 70% of the patients. Advances in the anticancer and antimicrobial chemotherapies might have decreased deaths due to myeloma itself or infection. Am. J. Hematol. 67:1-5, 2001.

Clinical characteristics of pain syndrome in patients with multiple myeloma

“…Это обусловлено тем, что боли могут являться первым признаком патоло-гического перелома или формирования остеолитического очага [1, 4,17]. Их раннее выявление позволяет принять меры по предупреждению дальнейшего смещения кост-ных отломков и предотвратить развитие корешковой ком-прессии или миелопатии [10,11].…”

Imaging Features of Extramedullary, Relapsed, and Refractory Multiple Myeloma involving the Liver Across Treatment With Cyclophosphamide, Lenalidomide, Bortezomib, and Dexamethasone

“…4 Extraosseous disease is more common in younger, male patients; nonsecretory/IgD/ light chain subtypes; advanced stage MM; extensive bone disease; and plasma cell leukemia. 2 Most common involved sites include the aerodigestive tract, soft tissue, liver, spleen, lymph nodes, testis, kidneys, pleura, and peritoneum.…”

“…5 The frequency of hepatic infiltration in MM autopsied patients is 30%, with discrete liver nodules in 13% of patients. 4 Liver involvement is more common in patients with IgA subtype and high IgG levels. 4 Clinically, this can manifest as extrahepatic biliary obstruction, ascites, nonobstructive jaundice, and hepatomegaly, but is more often asymptomatic.…”

“…4 Liver involvement is more common in patients with IgA subtype and high IgG levels. 4 Clinically, this can manifest as extrahepatic biliary obstruction, ascites, nonobstructive jaundice, and hepatomegaly, but is more often asymptomatic. [6][7][8][9][10] On CT, focal hepatic lesions usually appear as a solid, noncalcified mass with less enhancement.…”

Mieloma múltiple IgA: a propósito de un caso

“…La amiloidosis aparece en aproximadamente en el 15% de los casos y se puede manifestar como insuficiencia cardiaca, síndrome del túnel carpiano,... 5 Las causas principales de muerte son las hemorragias, infecciones y fallo renal.…”