Pathological personality traits (anxiety, depressive, hypochondriacal) significantly worsen the treatment and rehabilitation of patients with acute myocardial infarction. The aim of the work was to study the influence of genetic characteristics of patients on psychological readaptation in patients with acute coronary pathology. The review lists the identified candidate genes that affect the depression occurrence in these patients and represent potential targets for therapeutic intervention. Nucleotide sequence variants associated with a poor response to antidepressants in this category of patients are discussed. The use of genetic methods in examination, further consideration of the individual characteristics of each patient when choosing therapy, prescribing a rehabilitation course will allow for an individual approach to each patient, which in turn should improve the prognosis of the disease.