Clinical and psychological features in patients with incident and recurrent cases of benign paroxysmal positional vertigo

Makarov, Sergey; Dyukova, G. M.; Golubev, V L; Данилов, А. Б.

doi:10.17116/otorino20208505151

Cited by 3 publications

(3 citation statements)

References 27 publications

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“…The RD symptoms seriously affected patients’ daily work and life, leading to accidental falls in some elderly patients and increasing the medical economic burden. At the same time, it could also cause anxiety and depression in some patients ( Martellucci et al, 2016 ), and even developed into persistent postural perceptual dizziness (PPPD; Staab et al, 2017 ; Makarov et al, 2020 ). Although we have recognized the harm of this disease, the pathogenesis of residual dizziness is not particularly clear at present, and more clinical studies are urgently needed to explore.…”

Section: Introductionmentioning

confidence: 99%

“…Faralli et al suggested that the generation of RD may be related to the compensatory mechanism of the vestibular center ( Faralli et al, 2016 ; Makarov et al, 2020 ). Mario Faralli et al found that patients with earlier visits and treatment were less likely to develop RD symptoms.…”

Section: Introductionmentioning

confidence: 99%

“…Although we have recognized the harm of this disease, the pathogenesis of residual dizziness is not particularly clear at present, and more clinical studies are urgently needed to explore. Faralli et al suggested that the generation of RD may be related to the compensatory mechanism of the vestibular center (Faralli et al, 2016;Makarov et al, 2020). Mario Faralli et al found that patients with earlier visits and treatment were less likely to develop RD symptoms.…”

Section: Introductionmentioning

confidence: 99%

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Altered functional activity of the precuneus and superior temporal gyrus in patients with residual dizziness caused by benign paroxysmal positional vertigo

Lin,

Liu,

Liu

et al. 2023

Front. Neurosci.

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ObjectiveBenign paroxysmal positional vertigo (BPPV) is a common clinical vertigo disease, and the most effective treatment for this disease is canal repositioning procedures (CRP). Most patients return to normal after a single treatment. However, some patients still experience residual dizziness (RD) after treatment, and this disease’s pathogenesis is currently unclear. The purpose of this study is to explore whether there are abnormal brain functional activities in patients with RD by using resting-state functional magnetic resonance imaging (rs-fMRI) and to provide imaging evidence for the study of the pathogenesis of RD.Materials and methodsThe BPPV patients in the Second Affiliated Hospital of Xuzhou Medical University had been included from December 2021 to November 2022. All patients had been received the collection of demographic and clinical characteristics (age, gender, involved semicircular canal, affected side, CRP times, BPPV course, duration of RD symptoms, and whether they had hypertension, diabetes, coronary heart disease.), scale assessment, including Dizziness Handicap Inventory (DHI), Hamilton Anxiety Inventory (HAMA), Hamilton Depression Inventory (HAMD), rs-fMRI data collection, CRP treatment, and then a one-month follow-up. According to the follow-up results, 18 patients with RD were included. At the same time, we selected 19 healthy individuals from our hospital’s physical examination center who matched their age, gender as health controls (HC). First, the amplitude of low-frequency fluctuations (ALFF) analysis method was used to compare the local functional activities of the two groups of subjects. Then, the brain regions with different ALFF results were extracted as seed points. Functional connectivity (FC) analysis method based on seed points was used to explore the whole brain FC of patients with RD. Finally, a correlation analysis between clinical features and rs-fMRI data was performed.ResultsCompared to the HC, patients with RD showed lower ALFF value in the right precuneus and higher ALFF value in the right superior temporal gyrus (STG). When using the right STG as a seed point, it was found that the FC between the right STG, the right supramarginal gyrus (SMG), and the left precuneus was decreased in RD patients. However, no significant abnormalities in the FC were observed when using the right precuneus as a seed point.ConclusionIn patients with RD, the local functional activity of the right precuneus is weakened, and the local functional activity of the right STG is enhanced. Furthermore, the FC between the right STG, the right SMG, and the left precuneus is weakened. These changes may explain the symptoms of dizziness, floating sensation, walking instability, neck tightness, and other symptoms in patients with RD to a certain extent.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Altered functional activity of the precuneus and superior temporal gyrus in patients with residual dizziness caused by benign paroxysmal positional vertigo

Lin,

Liu,

Liu

et al. 2023

Front. Neurosci.

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A method for prediction functional dizziness after benign paroxysmal positional vertigo

Dyukova¹,

Кryukov²,

Makarov³

et al. 2021

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Incidence of Subsequent Injuries Associated with a New Diagnosis of Benign Paroxysmal Positional Vertigo and Effects of Treatment: A Nationwide Cohort Study

Mao,

Lin,

Lin

et al. 2024

JCM

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Background/Objectives: Benign paroxysmal positional vertigo (BPPV) is the most common cause of recurrent vertigo and the most common peripheral vestibular disorder. It is characterized by intense vertigo triggered by head and position changes. This study investigates the risk of subsequent injury in BPPV patients and the effects of treatment. Methods: A population-based retrospective cohort study was conducted using data from the Longitudinal Health Insurance Database 2005 in Taiwan. Patients with and without BPPV were identified between 2000 and 2017. The study outcomes were diagnoses of all-cause injuries. The Kaplan–Meier method determined the cumulative incidence rates of injury in both cohorts, and a log-rank test analyzed the differences. Cox proportional hazard models calculated each cohort’s 18-year hazard ratios (HRs). Results: We enrolled 50,675 patients with newly diagnosed BPPV and 202,700 matched individuals without BPPV. During follow-up, 47,636 patients were diagnosed with injuries (13,215 from the BPPV cohort and 34,421 from the non-BPPV cohort). The adjusted HR for injury in BPPV patients was 2.63 (95% CI, 2.49–2.88). Subgroup analysis showed an increased incidence of unintentional and intentional injuries in BPPV patients (aHR 2.86; 95% CI, 2.70–3.13 and 1.10; 95% CI, 1.04–1.21, respectively). A positive dose–response relationship was observed with increasing BPPV diagnoses. Treatment with canalith repositioning therapy (CRT) or medications reduced the risk of injury slightly but not significantly (aHR, 0.78; 95% CI, 0.37–1.29, 0.88; 95% CI, 0.40–1.40, respectively). Conclusions: BPPV is independently associated with an increased risk of injuries. CRT or medications have limited effects on mitigating this risk. Physicians should advise BPPV patients to take precautions to prevent injuries even after treatment.

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Clinical and psychological features in patients with incident and recurrent cases of benign paroxysmal positional vertigo

Cited by 3 publications

References 27 publications

Altered functional activity of the precuneus and superior temporal gyrus in patients with residual dizziness caused by benign paroxysmal positional vertigo

Altered functional activity of the precuneus and superior temporal gyrus in patients with residual dizziness caused by benign paroxysmal positional vertigo

A method for prediction functional dizziness after benign paroxysmal positional vertigo

Incidence of Subsequent Injuries Associated with a New Diagnosis of Benign Paroxysmal Positional Vertigo and Effects of Treatment: A Nationwide Cohort Study

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