Clinical and simple laboratory data associated with fatal outcomes in patients with acute pancreatitis

Abstract

Aims. The aim of the study was to evaluate the association of mortality in acute pancreatitis with clinical and simple laboratory data received on the day of admission. Patients and methods. In our retrospective study, the clinical and laboratory parameters of 99 patients with moderate and severe acute pancreatitis were analyzed. All patients were divided into two groups: deceased and survivors. Results. We did not find a significant difference in age and gender distribution between the comparison groups. However, a significant predominance of alcoholic etiology of acute pancreatitis, early hospitalization (up to 6 hours from the onset of the disease) of patients, and the number of necrotizing infected type in the deceased group were found. Concomitant pathology did not significantly differ in comparison groups. In patients from the deceased group, the total number of all complications was significantly higher than in the group of survivors-21 (100%) and 42 (53.8%) (p = 0.0001), respecting. Among the laboratory parameters determined on the day of admission, in the deceased group, there was a significant increase in stabs to 19.8 ± 9.8 and ESR, AST to 225.3 ± 47.5 U/L, urea to 11.2 ± 7.7 mmol/L, and creatinine to 173.6 ± 26.1 mmol/L. Conclusion. The alcoholic genesis of acute pancreatitis, necrotizing infected type of inflammation of the pancreas, presence of late complications, and comorbidities were significantly higher in the deceased group. The levels of stabs, ESR, AST, urea, and creatinine determined on the admission significantly dominated in the deceased group, which requires further study for the prediction of mortality of acute pancreatitis.

B Cells and Double-Negative B Cells (CD27−IgD−) Are Related to Acute Pancreatitis Severity

“…As an inflammatory process, acute pancreatitis results in excessive innate immune system activation and consequent release of pro-inflammatory mediators such as IL-6, IL-8, and TNF-α [5]. While the involvement of lymphocytes in this process has been partially explored through previous studies, the specific impact of alterations in peripheral lymphocyte subsets on Diseases 2024, 12, 18 2 of 15 prognostic accuracy, disease management, and hospitalization duration for patients with AP remains unclear [6,7]. Even though acute pancreatitis is a disease with high costs for the health care system, few studies have tried to relate the prediction of severity and length of hospital stay.…”