Clinical and x-ray oral evaluation in patients with congenital Zika Virus

Abstract

Objective: The aim of this study was to investigate possible malformations in the soft, bone and/or dental tissues in patients with congenital Zika Virus (ZIKV) by clinical and x-ray evaluation. Methodology: Thirty children born with ZIKV and 30 children born without ZIKV (control group) were included in the study. Patients were evaluated over 24 consecutive months according to the variables: sex, age, cleft palates, soft tissue lesions, alveolar ridge hyperplasia, short labial and lingual frenums, inadequate posture of the lingual and perioral muscles at rest, micrognathia, narrow palatine vaults, changes in the teeth shape and/or number, sequence eruption, spasms, seizures and eruption delay were evaluated. Chi-square test, Student's t-test and nominal logistic regression were used (p<0.05). Results: Among the 30 babies examined, the mean age of the first dental eruption was 10.8±3.8 with almost two-thirds of the children (n=18, 60%) experiencing eruptions of their first tooth after 9 months of age, nine children (30%) had inadequate lingual posture at rest, more than half of the children (n=18, 60%) had short labial or lingual frenums. ZIKV babies showed a high prevalence of clef palate (p<0.001), inadequate lingual posture at rest (p=0.004), micrognathia (p=0.002), changes in the shape and/or number of teeth (p=0.006), alteration in sequence of dental eruption (p<0.001) and muscles spasms (p=0.002). The delay eruption was associated with inadequate lingual posture at rest (p=0.047), micrognathia (p=0.002) and changes in the shape and/or number of teeth (p=0.021). The delayed eruption (p=0.006) and narrow palatine vaults (p=0.008) were independently associated with ZIKV. Moreover, female patients showed the most narrow palatine vaults (p=0.010). Conclusions: The children with ZIKV showed a greater tendency to have delayed eruption of the first deciduous tooth, inadequate lingual posture and short labial and lingual frenums.

Pesquisas odontológicas relacionadas com microcefalia: um estudo bibliométrico

“…Dentre os resumos incluídos neste trabalho, todos apresentaram como objetivos avaliar características orais, incidências e prevalência de alterações buco-dentária, educação em saúde bucal e condições de saúde bucal. Estes objetivos corroboram com os objetivos dos artigos publicados até o presente momento na literatura acerca do tema 5,6,19 . Uma abordagem mais ampla deve ser dado a correlação entre a odontologia e a microcefalia, pois pouco se conhece como será o comportamento dessas crianças no que se refere as características e cuidados de saúde bucal, mas também aspectos relacionados as ciências básicas como patogênese de doenças orais em crianças com microcefalia associadas a síndrome congênita do Zika vírus deve ser considerada, visto que é a partir desse conhecimento que estratégias terapeuticas e preventivas podem ser traçadas.…”

Developmental enamel defects and other oral problems in children with microcephaly associate with fetal exposure to zika virus (ZIKV)

“…42 The literature reveals that DDE can predispose to tooth decay, tooth sensitivity, malocclusion and aesthetic problems in preschoolers. 12,18 Its etiology is multifactorial and can be caused by genetic alterations and environmental factors, acquired after birth, such as infectious diseases. 16 Some studies indicate that gestational time and birth weight can interfere with the prevalence of DDE.…”

“…There are reports of the occurrence of tooth eruption delay and changes in the eruption sequence 6,8 lip hypotonia, absence of lip sealing and mouth breathing 3 and enamel opacity. 5,8 Carvalho et al, 11 described that, in a population of 30 children with this condition, 20% had inadequate tongue position at rest and also registered the presence of short labial or lingual curb, micrognathia, changes in the shape or number of teeth and spasms muscle.In addition to bone development, systemic, local or hereditary disorders that occur during enamel development can cause anomalies in its structure, affecting deciduous and / or permanent dentition [12][13][14] and these dental enamel development defects (DDE) predispose to a greater risk of dental caries. 15,16 According toLunardelli& Peres 17 the extent of the defect will depend on factors such as intensity and duration of the etiologic agent and period of crown formation.…”

“…19 Maternal disorders such as malnutrition and lack of vitamin A, which is responsible for the immune function and growth of ameloblastic cells, calcium and phosphorus deficiency, as well as other systemic events (diabetes, hypertension, congenital syphilis, exanthematic diseases), traumatic, environmental or genetic, can alter the cellular architecture and metabolism during the deposition of the organic matrix causing defects in the enamel structure. [12][13][14] In addition, other events have also been associated with DDE in recent investigations: the use of laryngoscope and endotracheal intubation, prolonged mechanical ventilation and oral tube nutrition, mandibular fractures, surgical trauma, and repair of cleft lip and palate 19 in addition to prematurity and low weight. 20,21 Thus, the objective of this study was to describe oral problems and oral health habits in children in early childhood with microcephaly associated with fetal exposure to the ZIKV and to verify factors potentially associated with the occurrence of DDE in this population.…”

COVID-19 Pandemic: Oral Repercussions and its Possible Impact on Oral Health

“…During these processes, viral infections can interrupt dental formation or morphogenesis as do well-known viruses, such as varicella-zoster, parvovirus B-19, herpes infections, rubella, cytomegalovirus and Zika virus [8]. Considering Zika virus as an example, dental shape, chronology and sequence of eruption are evidently altered [9]. These infections have caused changes in the tooth number, shape, size, structure, and/or position, in addition to delayed or absent tooth eruption.…”