Clinical application of endobronchial ultrasonography-guided transbronchial needle aspiration biopsy—a single center, large sample, real-world study

Abstract

Background Endobronchial ultrasonography-guided transbronchial needle aspiration biopsy (EBUS-TBNA) has been used for more than 10 years in China. Its clinical application and diagnostic value in different diseases with large sample was lack of report. Methods A retrospective analysis was performed about the application and diagnostic value of EBUS-TBNA in different disease of patients in Respiratory Intervention Center of Guangzhou Institute of Respiratory Health from January 2012 to July 2020. Results A total 5758 patients were included with 182 patients excluded for lack of information. Finally, data of 5576 patients (3798 males and 1778 females) were analyzed. For anesthetize, most patients were undergoing general anesthesia of intravenous with spontaneous breathing (69.4%), followed by general anesthesia of intravenous and inhalation with tracheal intubation and mechanical ventilation (17.9%) and conscious sedation and analgesia (12.8%). Lymph nodes were the main sites of biopsy obtained (76.4%). Tumors accounted for the highest proportion of disease (66.4%), followed by infection diseases (9.9%), sarcoidosis (3.9%), lymphoma (1.1%), and others (18.7%). The sensitivity of EBUS-TBNA for diagnosis of tumor was 89.7%, and 40.8% for infection diseases. There were significant differences in the puncture site and proportions of diseases between male and females (both p < 0.05). Higher diagnostic value was found in male patients (p < 0.05). Conclusion EBUS-TBNA has good diagnostic value for different mediastinal and central pulmonary space-occupying lesions diseases, with highest sensitivity for tumors. Higher diagnostic value was found in male patients.

Successful Retrieval of a Broken Aspiration Needle Penetrated into the Right Pulmonary Artery: A Case Report with Experience Sharing

“…The endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive medical technique [1]. Due to its excellent performance and high diagnostic accuracy, it has been increasingly used in the clinic to evaluate lesions in the mediastinal, hilar, and peribronchial areas [2].…”

Diagnostic efficacy and safety of radial probe endobronchial ultrasound-guided transbronchial needle aspiration for adjacent lesions in segmental or subsegmental bronchi: a single-center retrospective study

“…Techniques like non-invasive liquid biopsy test, computer tomography-guided transthoracic needle aspiration (CT-TTNA), electromagnetic navigation bronchoscopy (ENB), virtual navigation bronchoscopy (VNB), and radial probe endobronchial ultrasound-assisted transbronchial lung biopsy (REBUS-TBLB), are used to sample peripheral lung tissue lesions [ 3 – 9 ]. For mediastinal lesions, techniques like convex probe endobronchial ultrasound-guided transbronchial needle aspiration (CEBUS-TBNA) and endoscopic ultrasound-fine-needle aspiration are used [ 10 – 14 ]. However, for lesions located in the segmental or subsegmental bronchi from the 3rd − 5th order (i.e., not peripheral or mediastinal regions), CEBUS and endoscopic ultrasound (EUS) are usually inadequate.…”

“…In fact, its diagnostic yield is often comparable to, or even surpasses, that of surgical mediastinoscopy. The applications of CEBUS-TBNA are vast and include diagnosing intrapulmonary tumors, determining LN staging in lung cancer patients, uncovering unexplained hilar and/or mediastinal LN enlargement, and pinpointing mediastinal tumors [ 10 – 14 ].…”