Clinical application of new chitin non-woven fabric and new chitin sponge sheet as wound dressing

Abstract

Two types of new chitin dressings, mesh reinforcement type and sponge-sheet type, were manufactured and applied to skin wounds such as burns and donor sites. The advantages include pain relief, wound hemostasis, adherence and drying. In comparison to the regular type of chitin, the new dressings show no autolysis or breaking and have possibilities for long-term use in wound with extensive exudate. No side effects were observed. Key words: Chitin-Wound dressing -Local therapy of burn Donor site As research in cultured skin is moving towards clinical realization, wound dressings are moving from protection of the skin defect to a synthetic cover which will replace skin.The excellent properties of regular chitin dressing, namely its good pain relief, adherence and drying effect, have been presented previously [6]. The current study Fig. 1. New chitin non-woven fabric, mesh-reinforcement type of Fig. 2 a, b. Chitin sponge sheet (a) and electron micrograph (b) 10 x 10 cm of chitin sponge ( x 50)

Effects of Chitin and Sepia Ink Hybrid Hemostatic Sponge on the Blood Parameters of Mice

“…Previous studies indicated that chitin sponge had achieved good hemostatic effects. In addition to hemostasis, the advantages of chitin sponge included pain relief, adherence and drying [ 21 ]. In comparison with the regular type of chitin, the sponge showed no autolysis or breaking and have possibilities for long term use in wound with extensive exudate.…”

“…On the other hand, CTSH sponge has a sticky surface after absorbed body fluid, together with the extremely soft property, so it would adhere to the wound surface tightly, reducing the amount of bleeding and cutting down the bleeding time. In the degradation process of CTSH sponge, there was nearly no debris observation; deep tissues such as bone, tendon and nerve are sufficiently protected [ 21 ]. The basic properties of CTSH sponge were determined in this experiment, such as color, ash content, water absorption and deacetylation degree.…”

Biological Materials

“…Cellulose can be oxidized with in the fibrous state without altering the original shape (Olson et al, 1982). The oxidized cellulose is absorbed into the body upon implantation as a result of physical dissolution (not biodegradation).…”

“…However, current applications of chitin in medicine are quite limited. In Japan, wound covering is the only medical application of chitin approved by the Japanese government (Okashima et al, 1991). The major reason for few medical applications of this polymer is not due to its toxicity [chitin seems to be nontoxic (Tomihata and Ikada, 1997b)], but may be ascribed to its lack of superiority to synthetic biodegradable polymers such as glycolide and lactide polymers.…”

Naturally Prefabricated Marine Biomaterials: Isolation and Applications of Flat Chitinous 3D Scaffolds from Ianthella labyrinthus (Demospongiae: Verongiida)

“…Additionally, chitin applied to wounds may attract histiocytes containing abundant lysozyme. As a result, at the early stage of wounds, the chitin dressing may induce fibroblasts to produce fine type III collagen through histiocytes [66]. In fact, several studies have been carried out on chitin in the form of nanocrystals [67] or powders [64] and non-woven fabrics [65] as a potential hemostatic biomaterial.…”