Clinical assessment compared with cyst fluid analysis in the differential diagnosis of cystic lesions in the pancreas

Sand, Juhani; Hyöty, Marja; Mattila, Jouni; Dagorn, Jean–Charles; Nordback, Isto

doi:10.1016/s0039-6060(96)80113-9

Cited by 107 publications

(64 citation statements)

References 18 publications

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“…Previous attempts to differentiate neoplastic from nonneoplastic cysts include analysis of aspirated cyst fluid for cytology, enzymes and tumor markers (Rubin et al, 1994;Hammel et al, 1995;Sand et al, 1996;Sperti et al, 1996Sperti et al, , 1997. Thus, there is a need for a panel of markers that can accurately differentiate neoplastic from nonneoplastic pancreatic cysts.…”

Section: Discussionmentioning

confidence: 99%

Characterization of gene expression in mucinous cystic neoplasms of the pancreas using oligonucleotide microarrays

et al. 2004

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Section: Discussionmentioning

confidence: 99%

Characterization of gene expression in mucinous cystic neoplasms of the pancreas using oligonucleotide microarrays

et al. 2004

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“…Imaging in combination with fine-needle aspiration, cyst fluid analysis and cyst wall biopsy can usually differentiate between serous and mucinous cystic neoplasm, but its value for the diagnosis of dysplasia and cancer is relatively low [29, 47, 53, 54, 55, 56]. The aspiration of cyst fluid should for oncological reasons (needle tract within the potential future resection limits) preferably be done by endoscopic ultrasound, but the necessary technical expertise and experience in pancreatic diseases may not be available at a specific institution.…”

Section: Discussionmentioning

confidence: 99%

Risk of Malignancy in Serous Cystic Neoplasms of the Pancreas

et al. 2003

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Background: In contrast to mucinous cystic neoplasms of the pancreas, which are known to have considerable malignant potential, the serous variant is generally thought to be benign. There are, however, several reports of malignancy in serous cystic neoplasms of the pancreas. Aims: To assess the risk of malignancy of serous cystic tumors of the pancreas and to investigate specific clinical and histological features. Methods: Clinical and pathological characteristics of benign and malignant serous cystic neoplasms of the pancreas were investigated by a review of the literature and documented by a case of a serous cystadenocarcinoma and immunohistochemical analysis of a series of serous cystadenomas. Reviewing the literature prevalence, age and sex distribution of serous cystic neoplasms were analyzed. Results: The prevalence of cancer among serous cystic neoplasms reported since 1989 was 3%. Serous cystadenoma of the pancreas present at an earlier age (61 years) than serous cystadenocarcinoma (66 years; p = 0.056) and are symptomatic in the majority of patients.Pathological examination of the primary tumor was not able to distinguish cystadenoma from cystadenocarcinoma in 38% of cases. In 25% the diagnosis of cancer was established only after growth of metachronous metastases. In the present case, nuclear atypia, papillary structures, proliferation marker Ki-67 and p53 protein were increased in the primary tumor and/or metachronous metastasis. Conclusion: Serous cystic neoplasms of the pancreas do have malignant potential with a risk of malignancy of 3% and should be surgically treated if the operative risk is acceptable. Routine analysis of genetic and proliferation markers may improve diagnosis of malignancy in these tumors.

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“…In many instances, the clinical and radiological assessment is straightforward, and in fact may be more reliable than cyst fluid analysis [23]. In other cases, even though a precise diagnosis has not been reached, the indication for surgical resection is unequivocal because the patient has a symptomatic cystic lesion that is unlikely to be a pseudocyst.…”

Section: Indications For Fluid Sampling In Pancreatic Cystic Lesionsmentioning

confidence: 99%

Cystic Neoplasms of the Pancreas

Castillo

Warshaw

2001

Pancreatology

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Clinical assessment compared with cyst fluid analysis in the differential diagnosis of cystic lesions in the pancreas

Cited by 107 publications

References 18 publications

Characterization of gene expression in mucinous cystic neoplasms of the pancreas using oligonucleotide microarrays

Characterization of gene expression in mucinous cystic neoplasms of the pancreas using oligonucleotide microarrays

Risk of Malignancy in Serous Cystic Neoplasms of the Pancreas

Cystic Neoplasms of the Pancreas

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