Clinical characteristics and diagnostic value of specific immunoglobulin E antibodies in children with kiwi fruit allergy

Lee, Jeong Min; Jeon, Se Ah; Lee, Soo Young

doi:10.4168/aard.2013.1.1.73

Cited by 7 publications

(6 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to these large-scale studies, several small studies have assessed individual FA and major food allergens, re-evaluated the diagnostic decision point of food-specific IgE antibodies, or presented detailed case studies of the clinical and laboratory characteristics of FA in Korean children 17 25 26 27 28 29 30 31 32 33 34 35) .…”

Section: Main Triggers Of Ige-mediated Fa In Childrenmentioning

confidence: 99%

“…In most FA cases, the primary exposure to a food allergen is through ingestion, although some patients can experience symptoms after skin contact or inhalation of food proteins, as reported in Korean children 1 5 17 26 27 34) . Patients, care providers, and all people responsible for preparing or obtaining foods should be educated on how to read food labels in order to avoid specific food allergens.…”

Section: Management and Prevention Of Ige-mediated Food Allergiesmentioning

confidence: 99%

See 1 more Smart Citation

IgE-mediated food allergies in children: prevalence, triggers, and management

Lee

2017

Korean J Pediatr

View full text Add to dashboard Cite

Food allergy (FA) is a serious health problem, and severe FA such as food-induced anaphylaxis can often be life threatening. The incidence of FA has been increasing especially in children. They usually develop early in life and affect up to 10% of children. The 2 most common food allergens worldwide are milk and eggs, while the third one varies depending on the countries: peanuts in the United States and Switzerland, wheat in Germany and Japan, tree nuts in Spain, sesame in Israel, and walnuts in Korea. These common food allergens are different and difficult to identify because of differing study methodologies, population, geography, age, and dietary exposure patterns. The current management of FA relies on the strict avoidance of culprit allergens, the prompt treatment of allergic reactions, including epinephrine use for food-induced anaphylaxis, monitoring, and education to prevent further reactions. Newer approaches for tolerance induction to FA and FA immunotherapy have been under investigation but are not yet ready for real-world application. Thus, consistent and systematic education of patients, caregivers, and food-handling people is of primary importance for the management and prevention of FA reactions. This review assesses and compares IgE-mediated FA in children in Korea and other countries, with a focus on summarizing the prevalence, common triggers, and management of FA.

show abstract

Section: Main Triggers Of Ige-mediated Fa In Childrenmentioning

confidence: 99%

Section: Management and Prevention Of Ige-mediated Food Allergiesmentioning

confidence: 99%

IgE-mediated food allergies in children: prevalence, triggers, and management

Lee

2017

Korean J Pediatr

View full text Add to dashboard Cite

show abstract

“…Using the IgE-immunoblot assay, 7, 14, 25, and 26 kDa of IgE binding bands were identified, and a high degree of IgE crossreactivity between barley and wheat extracts were revealed using IgE-immunoblot inhibition and ELISA-inhibition tests. We recently evaluated the clinical characteristics of kiwi fruit allergy as well as kiwi specific IgE in Korean young children [47]. The study was based on data analysis of 18 patients, aged 11-108 months (median age 25 months), who were diagnosed with clinical kiwi fruit allergy at Ajou University Hospital from June 2005 to June 2012.…”

Section: Plant Fa In Korean Childrenmentioning

confidence: 99%

IgE mediated food allergy in Korean children: focused on plant food allergy

Lee

2013

Asia Pacific Allergy

Self Cite

View full text Add to dashboard Cite

Food allergy (FA) is a worldwide problem, with increasing prevalence in many countries, and it poses a clearly increasing health problem in Korea. In Korea, as a part of International Study of Asthma and Allergy in Childhood (ISAAC), a series of nation-wide population studies for prevalence of allergic disease in children were carried out, with the Korean version of ISAAC in 1995, 2000, and 2010. From the survey, the twelve-month prevalence of FA showed no significant differences from 1995 to 2000 in both age groups (6-12 years-old, 6.5% in 1995 and 5.7% in 2000; 12-15 year-olds, 7.4% in 1995 and 8.6% in 2000). The mean lifetime prevalence of FA which had ever been diagnosed by medical doctor was 4.7% in 6-12 year-olds and 5.1% in 12-15 year-olds respectively in 2000. In Korean children, the major causes of FA are almost same as in other countries, although the order prevalence may vary, a prime example of which being that peanut and tree nut allergies are not prevalent, as in western countries. Both pediatric emergency department (ED) visits and deaths relating to food induced anaphylaxis have also increased in western countries. From a study which based on data from the Korean Health Insurance Review and Assessment Service (KHIRA) from 2001 to 2007, the incidence of anaphylaxis under the age of 19 was 0.7-1 per 100,000 person-year, and foods (24.9%) were the most commonly identified cause of childhood anaphylaxis. In another epidemiologic study, involving 78889 patients aged 0-18 years who visited the EDs of 9 hospitals during June 2008 to Mar 2009, the incidence of food related anaphylaxis was 4.56 per 10,000 pediatric ED visits. From these studies, common causes of food related anaphylaxis were seafood, buckwheat, cow's milk, fruits, peanut and tree nuts. Although systematic epidemiologic studies have not reported on the matter, recently, plant foods related allergy has increased in Korean children. Among 804 children with moderate to severe atopic dermatitis, we reveals that the peanut sensitization rate in Korea reaches 18%, and that, when sensitized to peanut, patients showed a significant tendency to have co-sensitization with house dust mites, egg white, wheat, and soybean. The higher specific IgE to peanut was related to the likelihood of the patient developing severe systemic reactions. In another study, based on the data analysis of 69 patients under 4 years of age who had suspected peanut and tree nut allergy, 22 (31.9%) were sensitized to walnut (>0.35 kU/L, 0.45-27.4 kU/L) and 6 (8.7%) experienced anaphylaxis due to a small amount of walnut exposure. Furthermore, in this review, clinical and immunological studies on plant food allergies, such as buckwheat allergy, rice allergy, barley allergy, and kiwi fruit allergy, in Korean children are discussed.

show abstract

“…Mast cell activation results in the release of histamine and other inflammatory mediators which lead to the initial symptoms of kiwifruit allergy (Lin & Sampson, ). Kiwifruit, and pollen or plant‐derived foods such as birch and grass pollen (Bublin et al., ), avocado (Lee, Jeon, & Lee, ), banana (Sakai et al., ), peanut, and tree nuts (Sirvent et al, ) share homologous allergens and thus sensitization to one may result in symptoms following kiwifruit ingestion due to the presence of cross‐reactive protein allergens. For example, individuals who are sensitized to tree pollen have pollen‐specific IgE.…”

Section: Pathogenesis Clinical Features Diagnosis and Epidemiologymentioning

confidence: 99%

“…Thus, although one patient should avoid all foods with cross‐reactivity, another may only need to avoid kiwifruit in the fresh form. For kiwifruit, the potential allergen sources include pollens from birch tree, grass or ragweed, other kind of fruit (for example, banana) or vegetables (for example, avocado), peanut or tree nuts, and latex or related products (Merima Bublin et al., ; Lee et al., ; Ozkaya, Coskun, Turkmenoglu, & Samancı, ; Sirvent et al, ). Generally, apples, oranges, and pears or their combination can be used as the substitutes for kiwifruit in the diet due to similar amounts of vitamin C and dietary fiber.…”

Section: Management and Treatment Of Food Allergymentioning

confidence: 99%

A Comprehensive Review on Kiwifruit Allergy: Pathogenesis, Diagnosis, Management, and Potential Modification of Allergens Through Processing

Jin

Vanga

McCusker

et al. 2019

Comp Rev Food Sci Food Safe

View full text Add to dashboard Cite

Kiwifruit is rich in bioactive components including dietary fibers, carbohydrates, natural sugars, vitamins, minerals, omega‐3 fatty acids, and antioxidants. These components are beneficial to boost the human immune system and prevent cancer and heart diseases. However, kiwifruit is emerging as one of the most common elicitors of food allergies worldwide. Kiwifruit allergy results from an abnormal immune response to kiwifruit proteins and occur after consuming this fruit. Symptoms range from the oral allergy syndrome (OAS) to the life‐threatening anaphylaxis. Thirteen different allergens have been identified in green kiwifruit and, among these allergens, Act d 1, Act d 2, Act d 8, Act d 11, and Act d 12 are defined as the “major allergens.” Act d 1 and Act d 2 are ripening‐related allergens and are found in abundance in fully ripe kiwifruit. Structures of several kiwifruit allergens may be altered under high temperatures or strong acidic conditions. This review discusses the pathogenesis, clinical features, and diagnosis of kiwifruit allergy and evaluates food processing methods including thermal, ultrasound, and chemical processing which may be used to reduce the allergenicity of kiwifruit. Management and medical treatments for kiwifruit allergy are also summarized.

show abstract

Clinical characteristics and diagnostic value of specific immunoglobulin E antibodies in children with kiwi fruit allergy

Cited by 7 publications

References 26 publications

IgE-mediated food allergies in children: prevalence, triggers, and management

IgE-mediated food allergies in children: prevalence, triggers, and management

IgE mediated food allergy in Korean children: focused on plant food allergy

A Comprehensive Review on Kiwifruit Allergy: Pathogenesis, Diagnosis, Management, and Potential Modification of Allergens Through Processing

Contact Info

Product

Resources

About