Clinical characteristics and management of patients with rosacea in a tertiary dermatology center in Singapore from 2009 to 2013

Cheong, Kah Wai; Yew, Yik Weng; Lai, Yi Chun; Chan, Roy

doi:10.1111/ijd.13954

Cited by 5 publications

(6 citation statements)

References 19 publications

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“…An essential feature of rosacea is that symptoms may get worse after the action of trigger factors promoting vasodilatation. Common trigger factors in our study were consistent with the results described in the pieces of literature, such as emotional changes, hot environments, spicy food, and sun exposure 31,33,36 . Whereas middle‐aged and older adults (≥45 years) were relatively less affected by some of the influencing factors, younger age groups (≤30 years) were more affected by these factors.…”

Section: Discussionsupporting

confidence: 90%

“…Common trigger factors in our study were consistent with the results described in the pieces of literature, such as emotional changes, hot environments, spicy food, and sun exposure. 31,33,36 Whereas middle-aged and older adults (≥45 years) were relatively less affected by some of the influencing factors, younger age groups (≤30 years) were more affected by these factors. Elderly patients were less affected by stimuli, which may be related to the SIRT7-TLR2-NF-κB axis.…”

Section: Aggravating Factorsmentioning

confidence: 99%

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Differences in clinical characteristics of rosacea across age groups: A retrospective study of 840 female patients

Yang

Wang

Shucheng

et al. 2022

J of Cosmetic Dermatology

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Background: Aging remains a common influencing factor for many diseases. Previous studies have shown that age is significantly associated with rosacea among female cases and that the incidence of rosacea increases with age. However, previous studies did not specifically analyze the clinical characteristics of different age groups.Objective: This study aimed to analyze and compare the clinical characteristics of female patients of rosacea among different age groups. Methods:We conducted a retrospective study of 840 female rosacea subjects and compared cutaneous features, aggravating factors, systemic diseases, and psychological states across age groups. The patients were divided into three groups according to their age at diagnosis: ≤30 years，31-44 years，and ≥45 years.Results: In our study, the mean age of subjects was 35.9 ± 10.23 years. The common symptoms included telangiectasia (82.6%), persistent erythema (82.0%), burning/ stinging sensation (89.3%), dry sensation (74.0%), and pruritis (41.9%). Hot temperature (89.9%), emotional changes (67.3%), spicy food (55.6%), and sun exposure (50.7%) were the common aggravating factors. Some patients had comorbidities of systemic disorders (20.4%). Of the patients, 48.8% presented with anxiety and 35.2% with depression. The clinical characteristics were found to be significantly different among the different age groups. Middle-aged and older patients (≥45 years) were more likely to have more serious persistent erythema and telangiectasia. And these patients were relatively less affected by some of the influencing factors and had more systemic diseases of the digestive system, endocrine metabolic system, and cardiovascular system (p < 0.05). Conclusion:We revealed the impact of age on the characteristics of rosacea, which indicated that the clinical features of rosacea are more complex and more difficult to treat in females over the age of 45.

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Section: Discussionsupporting

confidence: 90%

Section: Aggravating Factorsmentioning

confidence: 99%

Differences in clinical characteristics of rosacea across age groups: A retrospective study of 840 female patients

Yang

Wang

Shucheng

et al. 2022

J of Cosmetic Dermatology

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“…The pooled proportions of ETR, PPR, PhR, and ocular rosacea among 9190 patients with rosacea, based on 39 studies (eTable 2 in the Supplement), were ETR: 56.7% (95% CI, 51.4%-62.0%; I 2 , 95.9%) (Figure 2), PPR: 43.2% (95% CI, 38.8%-47.6%; I 2 , 94.0%) (Figure 3), PhR: 7.4% (95% CI, 6.1%-8.9%; I 2 , 81.4%) (Figure 4), and ocular rosacea: 11.1% (95% CI, 6.7%-16.3%, I 2 , 98.1%) (Figure 5). The proportions of ETR and PPR appeared to be similar for male and female patients; the proportion of ETR was 58.3% (95% CI, 25.8%-87.2%) for men and 65.5% (95% CI, 41.8%-85.8%) for women based on 3 studies . Papulopustular rosacea was reported for 29.6% (95% CI, 10.5%-53.4%) of men and 34.6% (95% CI, 13.7%-59.3%) of women.…”

Section: Resultsmentioning

confidence: 99%

Assessment of Frequency of Rosacea Subtypes in Patients With Rosacea

et al. 2022

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IMPORTANCEFour distinct rosacea subtypes have traditionally been recognized, but the frequency of these subtypes among patients with rosacea remains unknown.OBJECTIVE To assess the frequency of 4 rosacea subtypes.DATA SOURCES This systemic review and meta-analysis included a search of 2 databases, PubMed and Embase, from inception of the databases to November 2, 2021. The search was filtered to include only studies of human participants published in English, French, and German.STUDY SELECTION Studies were screened independently by 2 of the authors and were included if they were original with a sample size of 25 or more patients and reported absolute numbers or frequency of patients affected by rosacea subtypes. Studies that did not report sufficient data to calculate the proportions of subtypes were excluded. DATA EXTRACTION AND SYNTHESISData extraction was performed independently and in duplicate by 2 of the authors, using the search term rosacea, according to the Preferred Reporting items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. The search term, objectives, and study protocol methods were defined before the study was initiated. A total of 292 studies were included for full-text assessment. Owing to the heterogeneity of the included studies, a random-effects model was used. MAIN OUTCOME AND MEASURESThe main outcome was the proportion of patients with rosacea in each of the 4 major subtype groups defined by the 2002 National Rosacea Society classification system. Measures were absolute numbers or frequency of patients affected by each of the 4 rosacea subtypes.RESULTS A total of 39 studies examining 9190 patients with rosacea were included. The pooled proportion of erythematotelangiectatic rosacea was 56.7% (95% CI, 51.4%-62.0%), of papulopustular rosacea was 43.2% (95% CI, 38.8%-47.6%), of phymatous rosacea was 7.4% (95% CI, 6.1%-8.9%), and of ocular rosacea was 11.1% (95% CI, 6.7%-16.3%). Subtype distribution occurred equally among men and women except for phymatous rosacea, which was more prevalent in men. Studies from Africa showed the lowest proportion of erythematotelangiectatic rosacea. Differences in frequency of subtypes were observed when stratification by publication year was performed. CONCLUSION AND RELEVANCEIn this systematic review and meta-analysis, differences were found in rosacea subtypes by patient sex and by continent of origin and publication year of included studies. Erythematotelangiectatic and papulopustular rosacea were the most prevalent subtypes, but data should be interpreted with caution. Future studies should use the phenotype-based rosacea approach.

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“…Consequently, this classification has been replaced with one based on phenotypes that focuses on the cutaneous aspects of rosacea, allowing for a personalized clinical evaluation and treatment for each patient . In patients with rosacea, it is common to obverse telangiectasia and persistent facial erythema, which can worsen periodically in the presence of trigger factors. , It is also common to find dome-shaped papules and pustules, and redness can be followed by nodules. , In addition to these clinical signs, various symptoms are mentioned by the patients, such as a tinkling burning sensation, especially in the frontal portion of the face . Localized facial edema as well as dry skin that can be harsh, scaly, and/or with pruritus can also occur .…”

Section: Rosaceamentioning

confidence: 99%

Rosacea Topical Treatment and Care: From Traditional to New Drug Delivery Systems

et al. 2023

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Rosacea is a multifactorial chronic inflammatory dermatosis characterized by flushing, nontransient erythema, papules and pustules, telangiectasia, and phymatous alterations accompanied by itching, burning, or stinging, the pathophysiology of which is not yet fully understood. Conventional topical treatments usually show limited efficacy due to the physical barrier property of the skin that hinders skin penetration of the active ingredients, thereby hampering proper drug skin delivery and the respective therapeutic or cosmetic effects. New advances regarding the physiopathological understanding of the disease and the underlying mechanisms suggest the potential of new active ingredients as promising therapeutic and cosmetic approaches to this dermatosis. Additionally, the development of new drug delivery systems for skin delivery, particularly the potential of nanoparticles for the topical treatment and care of rosacea, has been described. Emphasis has been placed on their reduced nanometric size, which contributes to a significant improvement in the attainment of targeted skin drug delivery. In addition to the exposition of the known pathophysiology, epidemiology, diagnosis, and preventive measures, this Review covers the topical approaches used in the control of rosacea, including skin care, cosmetics, and topical therapies, as well as the future perspectives on these strategies.

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Clinical characteristics and management of patients with rosacea in a tertiary dermatology center in Singapore from 2009 to 2013

Cited by 5 publications

References 19 publications

Differences in clinical characteristics of rosacea across age groups: A retrospective study of 840 female patients

Differences in clinical characteristics of rosacea across age groups: A retrospective study of 840 female patients

Assessment of Frequency of Rosacea Subtypes in Patients With Rosacea

Rosacea Topical Treatment and Care: From Traditional to New Drug Delivery Systems

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