Clinical characteristics and predictive score of dengue vs. chikungunya virus infections

Bonifay, Timothée; Vesin, Guillaume; Bidaud, Bastien; Bonnefoy, C.; Dueymes, Maryvonne; Djossou, Félix; Epelboin, Loïc

doi:10.1016/j.medmal.2018.09.010

Cited by 9 publications

(11 citation statements)

References 27 publications

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“…Abnormal results that have been observed in cases include lymphopenia (Ͻ500 to Ͻ1,000 ϫ 10 6 lymphocytes/liter) without leukopenia, mild thrombocytopenia (Ͼ100,000 ϫ 10 6 platelets/liter), mild transaminase elevations (transaminase levels 2 to 3 times the upper limit of normal), and an elevated C-reactive protein level ( Fig. 3) (25,59,60,66,71). Moderate to severe thrombocytopenia favors the diagnosis of dengue rather than chikungunya, particularly if hemorrhagic signs are present (59,60,66,76).…”

Section: Acute Clinical Presentation and Differential Diagnosismentioning

confidence: 99%

“…3) (25,59,60,66,71). Moderate to severe thrombocytopenia favors the diagnosis of dengue rather than chikungunya, particularly if hemorrhagic signs are present (59,60,66,76). However, these laboratory findings occur in other diseases on the differential and do not provide accurate diagnostic information.…”

Section: Acute Clinical Presentation and Differential Diagnosismentioning

confidence: 99%

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Beyond Fever and Pain: Diagnostic Methods for Chikungunya Virus

2019

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Chikungunya virus (CHIKV) is an alphavirus that is primarily transmitted by Aedes species mosquitoes. Though reports of an illness consistent with chikungunya date back over 200 years, CHIKV only gained worldwide attention during a massive pandemic that began in East Africa in 2004. Chikungunya, the clinical illness caused by CHIKV, is characterized by a rapid onset of high fever and debilitating joint pain, though in practice, etiologic confirmation of CHIKV requires the availability and use of specific laboratory diagnostics. Similar to infections caused by other arboviruses, CHIKV infections are most commonly detected with a combination of molecular and serological methods, though cell culture and antigen detection are reported. This review provides an overview of available CHIKV diagnostics and highlights aspects of basic virology and epidemiology that pertain to viral detection. Although the number of chikungunya cases has decreased since 2014, CHIKV has become endemic in countries across the tropics and will continue to cause sporadic outbreaks in naive individuals. Consistent access to accurate diagnostics is needed to detect individual cases and initiate timely responses to new outbreaks.

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Section: Acute Clinical Presentation and Differential Diagnosismentioning

confidence: 99%

Section: Acute Clinical Presentation and Differential Diagnosismentioning

confidence: 99%

Beyond Fever and Pain: Diagnostic Methods for Chikungunya Virus

2019

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“…However, the disease is rarely fatal (Chahar et al, 2009). On the other hand, DENV infection could develop into a severe illness and sometimes could be fatal depending on the immune history of the patient (Bonifay et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Dengue-chikungunya coinfection outbreak in children from Cali, Colombia in 2018–2019

Castellanos

Jaimes

Coronel-Ruiza

et al. 2021

International Journal of Infectious Diseases

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To identify the arbovirus involved in febrile cases identified in a pediatric clinic in Cali, Valle del Cauca province, Colombia, and study the clinical characteristics. Methods: A descriptive, prospective study enrolled 345 febrile children for 12 months in a pediatric clinic. Serum samples and medical record registers documenting signs and symptoms were analyzed to detect DENV, CHIKV, and ZIKV by reverse transcription-polymerase chain reaction and serology methods. Diagnosis at the time of admission and discharge were compared based on laboratory test results. Results: All patients were diagnosed as severe dengue at admission. Molecular detection and serology tests identified 143 CHIKV-positive (41.4%), 20 DENV-positive (5.8%), and 123 DENV-CHIKV coinfection patients (35.7%). DENV or CHIKV serology test results of these double-infected patients yielded poor performance to confirm patient cases. ZIKV infection was detected in 5 patients (1.4%) as double or triple infections. Conclusion:A sustained CHIKV circulation and transmission was confirmed causing febrile illness in children and indicating that this virus spreads even during the regular DENV season, leading to double infections and altering clinical symptoms. Specific clinical tests are necessary to closely identify the arbovirus involved in causing infectious diseases that can help in better treatment and mosquitotransmitted virus surveillance.

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“…In a comparative study concerning CHIKV and dengue virus infection in Gabon, myalgia was reported among the clinical symptoms in more than 70% of infected patients, 195/270 for CHIKV, and 40/53 for DENV, respectively [25]. A recent study conducted in French Guiana, points out the occurrence of muscle pain in 66.1% among CHIKV-infected patients (111, N = 168), and 80.9% among dengue-infected patients (366, N = 452) [26]. Concerning ZIKV, myalgia has been reported in 44% of infected patients (131, N = 297) in French Polynesia, and 60% (121, N = 203) in Martinique [27,28].…”

Section: Muscular Symptoms Associated With Arboviral Infectionmentioning

confidence: 99%

Arboviruses and Muscle Disorders: From Disease to Cell Biology

Filippone

Legros

Jeannin

et al. 2020

Viruses

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Infections due to arboviruses (arthropod-borne viruses) have dramatically increased worldwide during the last few years. In humans, symptoms associated with acute infection of most arboviruses are often described as “dengue-like syndrome”, including fever, rash, conjunctivitis, arthralgia, and muscular symptoms such as myalgia, myositis, or rhabdomyolysis. In some cases, muscular symptoms may persist over months, especially following flavivirus and alphavirus infections. However, in humans the cellular targets of infection in muscle have been rarely identified. Animal models provide insights to elucidate pathological mechanisms through studying viral tropism, viral-induced inflammation, or potential viral persistence in the muscle compartment. The tropism of arboviruses for muscle cells as well as the viral-induced cytopathic effect and cellular alterations can be confirmed in vitro using cellular models. This review describes the link between muscle alterations and arbovirus infection, and the underlying mechanisms.

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Clinical characteristics and predictive score of dengue vs. chikungunya virus infections

Cited by 9 publications

References 27 publications

Beyond Fever and Pain: Diagnostic Methods for Chikungunya Virus

Beyond Fever and Pain: Diagnostic Methods for Chikungunya Virus

Dengue-chikungunya coinfection outbreak in children from Cali, Colombia in 2018–2019

Arboviruses and Muscle Disorders: From Disease to Cell Biology

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