Introduction. The role of the fibrinolytic system in venous thrombosis
remains incompletely understood. This study aimed to evaluate the
effectiveness of the fibrinolytic system in patients with various types and
locations of venous thrombosis compared to healthy controls. Material and
Methods. The study included 100 patients with venous thrombosis and 100
healthy controls. Patients were stratified based on the type of venous
thrombosis (spontaneous vs. provoked) and the location (distal, proximal,
and atypical). Global fibrinolytic activity was assessed using euglobulin
clot lysis time, while specific fibrinolytic components measured included
plasminogen, tissue plasminogen activator, thrombin-activatable fibrinolysis
inhibitor, and plasminogen activator inhibitor-1. Results. Patients with
isolated distal and provoked venous thrombosis exhibited significantly
prolonged euglobulin clot lysis time compared to healthy controls (218.3 ?
41.1 vs. 185.6 ? 42.3 min, p=0.001; 208.2 ? 48.5 min vs. 185.6 ? 42.3 min,
p=0.018, respectively). Patients with provoked venous thrombosis
demonstrated higher plasminogen (127.1 ? 27.7 vs. 117.1 ? 24.5%, p=0.044)
and tissue plasminogen activator levels (20.0 ? 11.1 vs. 16.8 ? 8.1 ng/ml,
p=0.042) compared to controls. Thrombin-activatable fibrinolysis inhibitor
levels were significantly elevated in patients with both provoked (19.9 ?
4.0 vs. 17.1 ? 4.3 ng/ml, p=0.000) and spontaneous venous thrombosis (19.5 ?
6.0 vs. 17.1 ? 4.3 ng/ml, p=0.02), as well as in cases of isolated distal
(20.7 ? 5.0 vs. 17.1 ? 4.3 ng/ml, p=0.001) and proximal (19.4 ? 5.3 vs. 17.1
? 4.3 ng/ml, p=0.013) venous thrombosis when compared to healthy controls.
Conclusion. The study reveals significant variations in the fibrinolytic
process across different types and anatomical locations of venous thrombosis
compared to healthy individuals.