2016
DOI: 10.1097/scs.0000000000002985
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Clinical Considerations for Vascularized Composite Allotransplantation of the Eye

Abstract: Vascularized composite allotransplantation represents a potential shift in approaches to reconstruction of complex defects resulting from congenital differences as well as trauma and other acquired pathology. Given the highly specialized function of the eye and its unique anatomical components, vascularized composite allotransplantation of the eye is an appealing method for restoration, replacement, and reconstruction of the nonfunctioning eye. Herein, we describe conventional treatments for eye restoration an… Show more

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Cited by 12 publications
(11 citation statements)
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“…Some studies mentioned clinical aspects of WET from previously published results on mammalian organisms. 9 , 10 Because these did not provide novel data for assessment, they were excluded. Fourteen articles utilized mammalian and cadaveric models.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Some studies mentioned clinical aspects of WET from previously published results on mammalian organisms. 9 , 10 Because these did not provide novel data for assessment, they were excluded. Fourteen articles utilized mammalian and cadaveric models.…”
Section: Resultsmentioning
confidence: 99%
“…However, it had no accompanying usable veins for anastomosis and thus was discarded as a possibility. 9 …”
Section: Discussionmentioning
confidence: 99%
“… 15 For patient 2, neovascularization was present in the superior quadrant of the cornea. 20 The growth of corneal neovascularization resulted in exudates, fibrosis, inflammation and hemorrhage, threatening the survival of the graft. 11 , 16 The pathological corneal vessels act as a high-efficiency corridor to allow host immune effector elements travel to the graft bed and accelerate graft rejection.…”
Section: Discussionmentioning
confidence: 99%
“…However, VCAs are not routinely performed because a vast majority of VCA recipients develop chronic rejection and consequently require lifelong administration of immunosuppressive agents, which have adverse side effects. Therefore, the development of new strategies to prevent the lifelong use of immunosuppressants or the induction of immune tolerance is urgently needed [1][2][3][4].…”
Section: Introductionmentioning
confidence: 99%