Clinical Control in the Dual Diagnosis of Obstructive Sleep Apnea Syndrome and Rhinitis: A Prospective Analysis

Parikh, N.; Junaid, Imran; Sheinkopf, Lee E.; Randhawa, Inderpal; Santiago, Silverio; Klaustermeyer, William B.

doi:10.2500/ajra.2014.28.3977

Cited by 22 publications

(11 citation statements)

References 20 publications

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“…Of interest, our findings for non-allergic rhinitis in adults were stronger in males than in females, which could be due to hormonal effects on immune responses or rhinitis, or to misdiagnosis of symptoms of sleep apnea as rhinitis in male adults. Obstructive sleep apnea (OSA) is a common comorbidity of obesity 34 or allergic rhinitis 35, 36 , and uncontrolled rhinitis can lead to OSA 37 . Although we lacked data from sleep studies in study participants, adjustment for symptoms of OSA (not considered in previous studies) did not change the association between obesity and non-allergic rhinitis in adults.…”

Section: Discussionmentioning

confidence: 99%

Obesity and rhinitis in a nationwide study of children and adults in the United States

Han¹,

Forno²,

Gogna

et al. 2016

Journal of Allergy and Clinical Immunology

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Background Obesity has been associated with higher risk of asthma and asthma severity, both in children and adults. However, studies evaluating the relation between obesity and rhinitis have yielded conflicting results. Methods We performed a cross-sectional study of obesity indicators and rhinitis using data from 8,165 participants in the 2005–2006 National Health and Nutrition Examination Survey. Allergic rhinitis was defined as physician-diagnosed hay fever or allergy, presence of symptoms in the past 12 months, and at least one positive allergen-specific IgE. Non-allergic rhinitis was defined as physician diagnosis and symptoms but no positive allergen-specific IgE. Multivariate regression was used to assess the relationship between obesity and rhinitis in children and adults. Results In adults, being overweight or obese was associated with increased odds of non-allergic rhinitis (adjusted odds ratio [aOR]=1.43, 95% confidence interval [CI]=1.06–1.93, P=0.02). Similarly, central obesity was associated with increased odds of non-allergic rhinitis in adults (aOR=1.61, 95% CI=1.20–2.16, P<0.01). In an analysis stratified by gender, the observed associations were attenuated and became non-statistically significant in female adults, but remained significant in male adults. Overweight, obesity or central obesity were not associated with allergic rhinitis in adults. In children, central obesity was associated with reduced odds of allergic rhinitis (aOR=0.35, 95% CI=0.19–0.64, P<0.01). After stratification by gender, this association was similar in female and male children. Conclusions In adults, obesity is associated with increased odds of non-allergic rhinitis, particularly in males. In children, central obesity is associated with reduced odds of allergic rhinitis, regardless of gender.

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Section: Discussionmentioning

confidence: 99%

Obesity and rhinitis in a nationwide study of children and adults in the United States

Han¹,

Forno²,

Gogna

et al. 2016

Journal of Allergy and Clinical Immunology

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“…This discrepancy with the previous studies may be attributed to different methodologies and the fact that there was a high prevalence of AR among our cohort patients. Interestingly, one recent study reported a significant positive correlation between clinical control of rhinitis symptoms and clinical control of OSA [ 23 ]. Although the effect of treating AR on the control of OSA was not addressed in our study, we reported a trend of a slightly increased AHI (not statistically significant) among patients with AR and OSA in our study.…”

Section: Discussionmentioning

confidence: 99%

The prevalence of allergic rhinitis and atopic markers in obstructive sleep apnea

Gadi¹,

Wali²,

Koshak³

et al. 2016

JEGH

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Allergic rhinitis (AR) related inflammation might worsen the severity of obstructive sleep apnea (OSA), however, the relationship between the two disorders remains controversial. Our aim was to determine the prevalence of AR and atopic markers in OSA. This cross-sectional study recruited participants with sleep-related complaints referred to a sleep center from February 2013 to June 2014. The diagnosis of OSA was based on the Berlin questionnaire (BQ) followed by confirmatory polysomnography (PSG). The diagnosis of AR was made via focused history and clinical examination and was confirmed by measuring atopic markers. OSA was diagnosed in 97 out of 157 adults attending the sleep clinic (61.8%). There was a high prevalence of AR (52.6%) among OSA individuals. This was not significantly different from the frequency in the non-OSA individuals (p=0.5). Elevated total immunoglobulin E (IgE; >100K/μL), eosinophil count, and positive Phadiatop tests were found in individuals with OSA to be 37.1%, 11.3%, and 41.2%, respectively. Individuals without OSA have shown similar percentages. In our cohort, there was no significant difference in frequency of AR and atopy among participants with OSA compared to those without OSA.

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“…In this study, 12 of 45 of the patients with OSAS had the complication of allergic rhinitis; consequently, posterior nasal neurectomy may be effective for the management of these patients with allergy. 22…”

Section: Discussionmentioning

confidence: 99%

The Effect of Compound Nasal Surgery on Obstructive Sleep Apnea Syndrome

Hisamatsu

Kudo

Makiyama

2015

Am J Rhinol�Allergy

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Clinical Control in the Dual Diagnosis of Obstructive Sleep Apnea Syndrome and Rhinitis: A Prospective Analysis

Abstract: Our study showed a statistically significant positive correlation between clinical control of rhinitis symptoms and clinical control of OSAS. This study emphasizes the importance of achieving concurrent optimal control of both OSAS and AR/NAR.

Cited by 22 publications

References 20 publications

Obesity and rhinitis in a nationwide study of children and adults in the United States

Obesity and rhinitis in a nationwide study of children and adults in the United States

The prevalence of allergic rhinitis and atopic markers in obstructive sleep apnea

The Effect of Compound Nasal Surgery on Obstructive Sleep Apnea Syndrome

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