Clinical course of HTLV-1 infection associated intermediate uveitis

Siverio-Llosa, C.; Silva-Ocas, I; Galvez-Olortegui, Tomás; Arana-Kaik, G.

doi:10.1016/j.oftale.2021.05.004

Cited by 3 publications

(16 citation statements)

References 22 publications

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“… 5 After the exclusion of other causes of uveitis, the diagnosis is based on seropositivity for the HTLV-1 virus, although it can also be achieved with the polymerase chain reaction in aqueous humor and/or peripheral blood samples. 6 We discuss herein three confirmed cases of intermediate uveitis seen in patients from separate endemic regions of Colombia.…”

Section: Introductionmentioning

confidence: 81%

“…In the latter, it has been reported in Amerindian populations of Argentina, Paraguay, Chile, Bolivia, and Peru, as well as in Afro-American populations of Brazil, French Guyana, Suriname, Colombia, and Peru and in Japanese migrants in Bolivia. 6 …”

Section: Discussionmentioning

confidence: 99%

“…Bilateral inflammation is as frequent as unilateral; however, some authors report a higher proportion of patients with unilateral uveitis. 5 , 6 , 14 …”

Section: Discussionmentioning

confidence: 99%

“…While most HTLV-1 infections are asymptomatic, progress to ATLL is observed in 2–4% of cases and to TSP/HAM in 1–4% of cases. 2 – 9 …”

Section: Introductionmentioning

confidence: 99%

“… 9 Although data remain sparse, lifetime risk of associated inflammatory and autoimmune syndromes, such as uveitis, dermatitis, alveolitis/bronchiectasis, arthritis, nephritis, and myositis, may be close to 10%. 2 – 9 …”

Section: Introductionmentioning

confidence: 99%

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HTLV-1 uveitis in Colombia, an underrecognized complication of a hitherto neglected condition: a case series

Villamil-Gómez

Torres

Rojas-Hernández

et al. 2023

Therapeutic Advances in Infection

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Three Colombian patients with chronic HTLV-1 infection and severe intermediate and/or posterior uveitis are described. In one case, retinal ablation was necessary due to extensive peripheral degeneration, while the other two were successfully managed with local anti-inflammatory therapy. Gradual resolution of ocular findings was observed in all three patients on follow-up. Uveitis is a rarely recognized late complication of this infection, which represents a diagnostic and therapeutic challenge for clinicians in endemic countries. The real extension of HTLV-1 prevalence in Colombia and the frequency of its ophthalmologic complications remain to be determined.

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Section: Introductionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

“…Bilateral inflammation is as frequent as unilateral; however, some authors report a higher proportion of patients with unilateral uveitis. 5 , 6 , 14 …”

Section: Discussionmentioning

confidence: 99%

“…While most HTLV-1 infections are asymptomatic, progress to ATLL is observed in 2–4% of cases and to TSP/HAM in 1–4% of cases. 2 – 9 …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

HTLV-1 uveitis in Colombia, an underrecognized complication of a hitherto neglected condition: a case series

Villamil-Gómez

Torres

Rojas-Hernández

et al. 2023

Therapeutic Advances in Infection

View full text Add to dashboard Cite

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Diseases caused by human T-lymphotropic virus type 1 (HTLV-1)

Radygina,

Mochalova

2024

Microbiology Independent Research Journal (MIR Journal)

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INTRODUCTION: Human T-lymphotropic virus type 1 (HTLV-1) belongs to the Retroviridae family (genus Deltaretrovirus) and is directly involved in carcinogenesis. The HTLV-1 genome is represented by plus-strand RNA, which is transcribed into proviral DNA and then integrated into the genome of the host cell. After integration, HTLV-1 is present in the cells in the form of a provirus. As in the case of the human immunodeficiency virus, the main targets of HTLV-1 are CD4+ T lymphocytes. The virus is transmitted sexually, through blood transfusion, and breastfeeding by biological fluids – sperm, blood, and breast milk. The epidemiology of HTLV-1 remains a mystery: clusters of high endemicity are often located near areas where the virus is virtually absent. AIM: To analyze and discuss the clinical picture, diagnostics, and treatment of diseases caused by HTLV-1. METHODS: A literature search was conducted in the databases PubMed, eLIBRARY.ru, and cyberleninka.ru using the keywords: “HTLV-1” + “diseases”, “HTLV-1” + “diagnosis”, “HTLV-1” + “epidemiology”, “HTLV-1” + “treatment”, “HTLV-1” + “Russia” in English and Russian languages. The primary search was conducted for papers published in 2020–2024. RESULTS: HTLV-1 infection is associated with diseases such as T-cell leukemia/lymphoma and myelopathy/tropical spastic paraparesis. HTLV-1 infection causes pathologies in most organs of the human body. Because diseases associated with HTLV-1 are most often asymptomatic, etiological diagnoses are performed at the stage of pathological development or when screening donor blood for pathogens. CONCLUSION: In this review, we analyzed and discussed the clinical manifestations and course of diseases caused by HTLV-1, their diagnosis, and treatment. The lack of reliable population-based studies on the prevalence of this virus is alarming. In fact, HTLV-1 is diagnosed only in blood donors and pregnant women. Currently, this virus is considered endemic to several territories (Africa, Australia, the Middle East, Japan, etc.) and some indigenous peoples. However, we consider it important to draw the attention of both epidemiologists and clinicians to HTLV-1, given the unprecedented migration flows and international connections in the modern world.

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Заболевания, Ассоциированные С Т-Лимфотропным Вирусом Типа 1 Человека (HTLV-1)

Радыгина,

Мочалова

2024

Microbiology Independent Research Journal (MIR Journal)

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ВВЕДЕНИЕ: Т-лимфотропный вирус типа 1 человека (HTLV-1) относится к семейству Retroviridae (род Deltaretrovirus) и напрямую участвует в канцерогенезе. Геном HTLV-1 представлен плюс-цепью РНК, которая транскрибируется в провирусную ДНК, а затем встраивается в геном клетки хозяина. После интеграции HTLV-1 присутствует в клетке в форме провируса. Как и для вируса иммунодефицита человека, основными мишенями HTLV-1 служат CD4+ T-лифоциты. Вирус передается через биологические жидкости организма: сперму, кровь и грудное молоко, – то есть половым путем, при гемотрансфузии и грудном вскармливании. Что касается эпидемиологии HTLV-1, то она до сих пор остается загадкой: кластеры с высокой эндемичностью часто расположены вблизи районов, где вирус практически отсутствует. ЦЕЛЬ: Проанализировать клиническую картину, диагностику и лечение заболеваний, вызванных HTLV-1. МЕТОДЫ: Проведен поиск литературы в базах PubMed, elibrary.ru и cyberleninka.ru по ключевым словам: «HTLV-1»+«diseases», «HTLV-1»+«diagnosis», «HTLV-1»+«epidemiology», «HTLV-1»+«treatment», «HTLV-1»+«Russia»; «HTLV-1»+«болезни», «HTLV-1»+«диагностика», «HTLV-1»+«эпидемиология», «HTLV-1»+«лечение», «HTLV-1»+«Россия». Основной поиск проведен за 2020–2024 гг. РЕЗУЛЬТАТЫ: С HTLV-1 связаны такие заболевания, как Т-клеточный лейкоз/лимфома и миелопатия/тропический спастический парапарез. При HTLV-1-инфекции регистрируют патологии большинства систем органов. В связи с тем, что ассоциированные с HTLV-1 заболевания чаще всего протекают бессимптомно, этиологическую диагностику проводят уже на стадии развития патологии или при скрининге крови доноров на патогены. ЗАКЛЮЧЕНИЕ: В обзоре рассмотрены вопросы клинических проявлений и течения заболеваний, вызванных HTLV-1, их диагностики и лечения. Несколько настораживает отсутствие серьезных популяционных исследований по распространенности этого вируса – фактически, диагностика на HTLV-1 предусмотрена только у доноров и у беременных. До сих пор этот вирус считается эндемичным для ряда территорий (Африка, Австралия, Ближний Восток, Япония и др.) и некоторых коренных народов, но, учитывая беспрецедентные миграционные потоки и международные связи в современном мире, мы считаем важным привлечь к нему внимание как эпидемиологов, так и клиницистов.

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Clinical course of HTLV-1 infection associated intermediate uveitis

Cited by 3 publications

References 22 publications

HTLV-1 uveitis in Colombia, an underrecognized complication of a hitherto neglected condition: a case series

HTLV-1 uveitis in Colombia, an underrecognized complication of a hitherto neglected condition: a case series

Diseases caused by human T-lymphotropic virus type 1 (HTLV-1)

Заболевания, Ассоциированные С Т-Лимфотропным Вирусом Типа 1 Человека (HTLV-1)

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